| 1. |
- Ekborn, Andreas, et al.
(författare)
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High-dose cisplatin with amifostine : ototoxicity and pharmacokinetics
- 2004
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Ingår i: The Laryngoscope. - : Wiley. - 0023-852X .- 1531-4995. ; 114:9, s. 1660-1667
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES/HYPOTHESIS: Ototoxicity is a common side effect of high-dose cisplatin treatment. Thiol-containing chemoprotectors ameliorate cisplatin ototoxicity under experimental conditions. The trial was initiated to test the efficacy of amifostine protection in high-dose cisplatin treatment (125-150 mg/m) for metastatic malignant melanoma, to correlate the ototoxic outcome with cisplatin pharmacokinetics, and to evaluate the importance of using a selective analytical method for the quantification of cisplatin. STUDY DESIGN: Prospective study of 15 patients with stage IV malignant melanoma. METHODS: Clinical follow-up of therapeutic response, pure-tone audiometry, and analysis of cisplatin and its monohydrated complex in blood ultrafiltrate by liquid chromatography with postcolumn derivatization were performed. Ultrafiltered blood platinum was analyzed by inductively coupled plasma mass spectrometry. RESULTS: Ototoxicity and gastrointestinal toxicity were the most prominent side effects. Three patients ultimately required hearing aids. All patients had audiometric changes at one or more frequencies after the second treatment course, and all but one patient reported auditory symptoms. No correlation was found between hearing loss and blood cisplatin pharmacokinetics. Platinum levels determined by inductively coupled plasma mass spectrometry were higher than total platinum levels calculated from cisplatin and monohydrated complex concentrations obtained by liquid chromatography analysis. CONCLUSION: Ototoxicity was unacceptable despite amifostine treatment. Cisplatin pharmacokinetics during the first treatment course were not predictive of hearing loss. Amifostine caused a lowering of dose-normalized area under the concentration-time curve for cisplatin and monohydrated complex. Use of the unselective inductively coupled plasma mass spectrometry analysis leads to an overestimation of active drug. Selective analysis of cisplatin is especially important when evaluating cisplatin pharmacokinetics during chemoprotector treatment.
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| 3. |
- Karlsson, Per Erik, 1957, et al.
(författare)
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A cumulative ozone uptake-response relationship for the growth of Norway spruce saplings
- 2004
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Ingår i: Environmental Pollution. - : Elsevier BV. - 0269-7491. ; 128:3, s. 405-417
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Tidskriftsartikel (refereegranskat)abstract
- Norway spruce saplings [Picea abies (L.) Karst.] were exposed during four growing seasons to different ozone treatments in open-top chambers: charcoal filtered air (CF), non-filtered air (NF) and non-filtered air with extra ozone (NF+, 1.4xambient concentrations). The CF and NF + ozone treatments were combined with phosphorous deficiency and drought stress treatments. The total biomass of the trees was harvested at different intervals during the experimental period. The ozone uptake to current-year needles of the Norway spruce saplings was estimated using a multiplicative stomatal conductance simulation model. There was a highly significant correlation between the reduction of total biomass and the estimated cumulative ozone uptake, which did not vary when different thresholds were applied for the rate of ozone uptake. The reduction of the total biomass was estimated to 1 per 10 mmol m(-2) cumulated ozone uptake, on a projected needle area basis. (C) 2003 Elsevier Ltd. All rights reserved.
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| 4. |
- Karlsson, Per Erik, 1957, et al.
(författare)
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Impact of ozone on the growth of birch (Betula pendula) saplings
- 2003
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Ingår i: Environmental Pollution. - 0269-7491. ; 124:3, s. 485-495
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Tidskriftsartikel (refereegranskat)abstract
- Saplings of one half-sib family of birch, Betula pendula, were exposed to three levels of ozone in open-top chambers (OTCs) during two growing seasons 1997-1998. The ozone treatments were non-filtered air (NF, accumulated daylight AOT40 over the two growing seasons of 3.0 mul l(-1) h), non-filtered air with extra ozone (NF +, accumulated daylight AOT40 of 27.3 mul l(-1) h) and nonfiltered air with additional extra ozone (NF++, accumulated daylight AOT40 of 120 mul l(-1) h), The birch saplings, including the roots, were harvested after the first and second growing seasons. After the first growing season, the NF++ treatment reduced the total wood biomass by 22%, relative to the NF treatment. There was no further reduction of the total wood biomass in the NF++ treatment after the second growing season. The root biomass was reduced by 30% after the first growing season. The shoot/root ratio, as well as the proportional biomass of leaves, were increased by ozone during both years. The ozone impact on the relative growth rate was estimated to -2% per 10 mul l(-1) h daylight AOT40 per growing season. (C) 2003 Elsevier Science Ltd. All rights reserved.
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| 5. |
- Krogstad, Anne-Lene, 1956, et al.
(författare)
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Evaluation of objective methods to diagnose palmar hyperhidrosis and monitor effects of botulinum toxin treatment.
- 2004
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Ingår i: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. - : Elsevier BV. - 1388-2457. ; 115:8, s. 1909-16
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate (1) if laboratory tests may be a useful complement in diagnosing palmar hyperhidrosis and (2) if such tests can be used in the follow up examination of treatment effects. METHODS: Repeated measurements of evaporation and conductance were made in glabrous skin on hands and compared with subjective estimates of the degree of sweating in 20 control subjects and 20 patients with a history of palmar hyperhidrosis. In addition, 17 patients were monitored for up to 6 months after treatment of the hands with botulinum toxin A. RESULTS: Before treatment, evaporation in the palms was higher in the patients than in the control subjects but skin conductance did not differ between the groups. After treatment both evaporation and skin conductance decreased markedly in the patients and then slowly returned towards pretreatment values. CONCLUSIONS: Measurements of evaporation, but not skin conductance, may be a useful objective adjunct when diagnosing palmar hyperhidrosis. Both methods can, however, be used to monitor intraindividual changes of sweating over time.
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| 6. |
- Ros, Axel, et al.
(författare)
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Laparoscopic cholecystectomy versus mini-laparotomy cholecystectomy : a prospective, randomized, single-blind study
- 2001
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Ingår i: Annals of Surgery. - : Ovid Technologies (Wolters Kluwer Health). - 0003-4932 .- 1528-1140. ; 234:6, s. 741-749
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To analyze outcomes after open small-incision surgery (minilaparotomy) and laparoscopic surgery for gallstone disease in general surgical practice.Methods: This study was a randomized, single-blind, multicenter trial comparing laparoscopic cholecystectomy (LC) to minilaparotomy cholecystectomy (MC). Both elective and acute patients were eligible for inclusion. All surgeons normally performing cholecystectomy, both trainees under supervision and consultants, operated on randomized patients. LC was a routine procedure at participating hospitals, whereas MC was introduced after a short training period. All nonrandomized cholecystectomies at participating units during the study period were also recorded to analyze the external validity of trial results. The randomization period was from March 1, 1997, to April 30, 1999.Results: Of 1,705 cholecystectomies performed at participating units during the randomization period, 724 entered the trial and 362 patients were randomized to each of the procedures. The groups were well matched for age and sex, but there were fewer acute operations in the LC group than the MC group. In the LC group 264 and in the MC group 150 operations were performed by surgeons who had done more than 25 operations of that type. Median operating times were 100 and 85 minutes for LC and MC, respectively. Median hospital stay was 2 days in each group, but in a nonparametric test it was significantly shorter after LC. Median sick leave and time for return to normal recreational activities were shorter after LC than MC. Intraoperative complications were less frequent in the MC group, but there was no difference in the postoperative complication rate between the groups. There was one serious bile duct injury in each group, but no deaths.Conclusions: Operating time was longer and convalescence was smoother for LC compared with MC. Further analyses of LC versus MC are necessary regarding surgical training, surgical outcome, and health economy.
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| 8. |
- Skarby, L., et al.
(författare)
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Growth of Norway spruce (Picea abies) in relation to different ozone exposure indices: a synthesis
- 2004
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Ingår i: Atmospheric Environment. - 1352-2310. ; 38:15, s. 2225-2236
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Tidskriftsartikel (refereegranskat)abstract
- In the Goteborg Ozone-Spruce Project (GOSP), two independent open-top chamber experiments were conducted during four growing seasons, using one clone of Norway spruce (Picea abies). The experiments tested the impact of ozone, alone and in combination with low phosphorus supply and in combination with drought stress, respectively, on biomass accumulation. In this paper, the results from both experiments were combined for the first time in order to analyse the relationship between relative biomass accumulation and different exposure indices (accumulated exposure over a threshold (AOT) with different cut-off concentrations, and the sum of ozone concentrations above 60 nl l(-1), referred to as SUM06). In addition, a pooled analysis was made on several European studies of Norway spruce as a first effort to synthesize independent data and test the relative growth in relation to the AOT40 index. Significant negative relationships between the relative biomass of the GOSP-clone and the different indices were obtained. AOT20 and AOT30 resulted in the highest correlations. Based on the regression model, ozone is predicted to reduce the biomass of the GOSP-clone by 1% at the critical level for forest trees in Europe, a seasonal AOT40 of 10 mul l(-1) h. A significant negative relationship between relative growth and AOT40 was obtained also with the European data set. At the present ozone critical level, the model predicted a 6% reduction in growth for the most sensitive Norway spruce trees in this data set. (C) 2004 Elsevier Ltd. All rights reserved.
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