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Träfflista för sökning "WFRF:(Williams C) srt2:(1995-1999)"

Sökning: WFRF:(Williams C) > (1995-1999)

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  • Dunham, I, et al. (författare)
  • The DNA sequence of human chromosome 22
  • 1999
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
  • Tidskriftsartikel (refereegranskat)
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  • Odeberg, Jacob, et al. (författare)
  • Cloning and characterization of ZNF189, a novel human Krüppel-like zinc finger gene localized to chromosome 9q22-q31.
  • 1998
  • Ingår i: Genomics. - : Elsevier BV. - 0888-7543 .- 1089-8646. ; 50, s. 233-
  • Tidskriftsartikel (refereegranskat)abstract
    • A 3-kb-long cDNA encoding a Krüppel-like human zinc finger protein was isolated and mapped to chromosome 9q22-q31. The ZNF189 gene encodes a protein with 16 zinc fingers at its C-terminus and belongs to the Krüppel-associated box (KRAB)-containing group of zinc finger proteins. Four differently spliced cDNA transcripts, differing at the 5' coding region where a KRAB A repressor domain is encoded, were isolated. In addition, Northern blot analysis indicates the presence of two additional unidentified splice variants. Comparison of cDNA and genomic sequences shows that the ZNF189 gene spans approximately 11 kb and is organized into at least four exons, the large 3'-end exon coding for the complete zinc finger domain and the 3' untranslated region. ZNF189 is expressed in all tissues and cell types currently investigated, at varying levels, but with a tissue- or cell-type-restricted expression pattern for the different splice variants. ZNF189 is conserved in the genome of several mammalian species. Direct sequencing of the ZNF189 gene in microdissected tumor biopsies of sporadic basal cell carcinoma and squamous cell carcinoma reveals no mutations in the coding sequence or at exon/intron boundaries.
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  • Huckvale, M., et al. (författare)
  • Opportunities for Computer-Aided Instruction in Phonetics and Speech Communication Provided by the Internet
  • 1997
  • Ingår i: 5th European Conference on Speech Communication and Technology, EUROSPEECH 1997. - : The International Speech Communication Association (ISCA). ; , s. 1919-1922
  • Konferensbidrag (refereegranskat)abstract
    • Spoken language engineering is starting to deliver technological products to the commercial market and has an important future role in supporting the multilingual structures of modern Europe. The field will be driven forward by basic science and applied research by experts drawn from a variety of backgrounds; among them: linguistics, psychology, computer science and electrical engineering. The wide range of expertise required in this discipline brings difficulties for our educational systems, but also challenges us to use our knowledge of technology and communication to improve the quality and effectiveness of teaching and learning. This paper investigates how resources currently available on the Internet could be exploited in the education of phonetics and speech communication. It discusses the technology, outlines the requirements for computer-aided learning in the field, gives a taxonomy of the available components with examples, and criticises the main weaknesses in the current provision.
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