Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design

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Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design

Nielsen, Niklas (author): Helsingborg Hospital

Wetterslev, Jorn (author): Copenhagen University Hospital

al-Subaie, Nawaf (author): University of London St Georges Hospital

Andersson, Bertil (author): Sahlgrens University Hospital

Bro-Jeppesen, John (author): Copenhagen University Hospital

Bishop, Gillian (author): Campelltown Hospital

Brunetti, Iole (author): IRCCS San Martino University Hospital

Cranshaw, Julius (author): Royal Bournemouth Hospital

Cronberg, Tobias (author): Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Edqvist, Kristin (author): Central Hospital Karlstad

Erlinge, David (author): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Gasche, Yvan (author): University Hospital Geneva

Glover, Guy (author): Guys and St Thomas Hospital

Hassager, Christian (author): Copenhagen University Hospital

Horn, Janneke (author): University of Amsterdam

Hovdenes, Jan (author): Oslo University Hospital

Johnsson, Jesper (author): Helsingborg Hospital

Kjaergaard, Jesper (author): Copenhagen University Hospital

Kuiper, Michael (author): Leeuwarden Medical Centre

Langorgen, Jorund (author): Haukeland Hospital

Macken, Lewis (author): Royal N Shore Hospital

Martinell, Louise (author): Sahlgrens University Hospital

Martner, Patrik (author): Sahlgrens University Hospital

Pellis, Thomas (author): Department Intens Care, Pordenone

Pelosi, Paolo (author): IRCCS San Martino University Hospital,University of Wales Hospital

Petersen, Per (author): Örebro University Hospital

Rundgren, Malin (author): Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Saxena, Manoj (author): St George Hospital

Svensson, Robert (author): Östergötlands Läns Landsting,Anestesi- och intensivvårdskliniken VIN

Stammet, Pascal (author): Centre Hospital Luxembourg

Thoren, Anders (author): Sahlgrens University Hospital

Unden, Johan (author): Skåne University Hospital

Walden, Andrew (author): Royal Berkshire Hospital

Wallskog, Jesper (author): Kungalv Hospital

Wanscher, Michael (author): Copenhagen University Hospital

Wise, Matthew P (author): University of Wales Hospital

Wyon, Nicholas (author): Linköpings universitet,Östergötlands Läns Landsting,Anestesi- och intensivvårdskliniken US,Hälsouniversitetet

Aneman, Anders (author): Liverpool Hospital

Friberg, Hans (author): Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Persson, Stefan (author)

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Elsevier, 2012
2012
English.
In: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 163:4, s. 541-548

Related links:: http://dx.doi.org/10...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32 degrees C to 34 degrees C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known. less thanbrgreater than less thanbrgreater thanMethods The TTM trial is an investigator-initiated, international, randomized, parallel-group, and assessor-blinded clinical trial designed to enroll at least 850 adult, unconscious patients resuscitated after out-of-hospital cardiac arrest of a presumed cardiac cause. The patients will be randomized to a target temperature management of either 33 degrees C or 36 degrees C after return of spontaneous circulation. In both groups, the intervention will last 36 hours. The primary outcome is all-cause mortality at maximal follow-up. The main secondary outcomes are the composite outcome of all-cause mortality and poor neurologic function (cerebral performance categories 3 and 4) at hospital discharge and at 180 days, cognitive status and quality of life at 180 days, assessment of safety and harm. less thanbrgreater than less thanbrgreater thanDiscussion The TTM trial will investigate potential benefit and harm of 2 target temperature strategies, both avoiding hyperthermia in a large proportion of the out-of-hospital cardiac arrest population.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: American Heart J ...

By the university: Linköping University; Lund University

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Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design

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