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| 2. |
- Abe, O, et al.
(author)
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Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
- 2005
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In: The Lancet. - 1474-547X. ; 365:9472, s. 1687-1717
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Journal article (peer-reviewed)abstract
- Background Quinquennial overviews (1985-2000) of the randomised trials in early breast cancer have assessed the 5-year and 10-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival. Here, we report the 10-year and 15-year effects. Methods Collaborative meta-analyses were undertaken of 194 unconfounded randomised trials of adjuvant chemotherapy or hormonal therapy that began by 1995. Many trials involved CMF (cyclophosphamide, methotrexate, fluorouracil), anthracycline-based combinations such as FAC (fluorouracil, doxombicin, cyclophosphamide) or FEC (fluorouracil, epirubicin, cyclophosphamide), tamoxifen, or ovarian suppression: none involved taxanes, trastuzumab, raloxifene, or modem aromatase inhibitors. Findings Allocation to about 6 months of anthracycline-based polychemotherapy (eg, with FAC or FEC) reduces the annual breast cancer death rate by about 38% (SE 5) for women younger than 50 years of age when diagnosed and by about 20% (SE 4) for those of age 50-69 years when diagnosed, largely irrespective of the use of tamoxifen and of oestrogen receptor (ER) status, nodal status, or other tumour characteristics. Such regimens are significantly (2p=0 . 0001 for recurrence, 2p<0 . 00001 for breast cancer mortality) more effective than CMF chemotherapy. Few women of age 70 years or older entered these chemotherapy trials. For ER-positive disease only, allocation to about 5 years of adjuvant tamoxifen reduces the annual breast cancer death rate by 31% (SE 3), largely irrespective of the use of chemotherapy and of age (<50, 50-69, &GE; 70 years), progesterone receptor status, or other tumour characteristics. 5 years is significantly (2p<0 . 00001 for recurrence, 2p=0 . 01 for breast cancer mortality) more effective than just 1-2 years of tamoxifen. For ER-positive tumours, the annual breast cancer mortality rates are similar during years 0-4 and 5-14, as are the proportional reductions in them by 5 years of tamoxifen, so the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis. These results combine six meta-analyses: anthracycline-based versus no chemotherapy (8000 women); CMF-based versus no chemotherapy (14 000); anthracycline-based versus CMF-based chemotherapy (14 000); about 5 years of tamoxifen versus none (15 000); about 1-2 years of tamoxifen versus none (33 000); and about 5 years versus 1-2 years of tamoxifen (18 000). Finally, allocation to ovarian ablation or suppression (8000 women) also significantly reduces breast cancer mortality, but appears to do so only in the absence of other systemic treatments. For middle-aged women with ER-positive disease (the commonest type of breast cancer), the breast cancer mortality rate throughout the next 15 years would be approximately halved by 6 months of anthracycline-based chemotherapy (with a combination such as FAC or FEC) followed by 5 years of adjuvant tamoxifen. For, if mortality reductions of 38% (age <50 years) and 20% (age 50-69 years) from such chemotherapy were followed by a further reduction of 31% from tamoxifen in the risks that remain, the final mortality reductions would be 57% and 45%, respectively (and, the trial results could well have been somewhat stronger if there had been full compliance with the allocated treatments). Overall survival would be comparably improved, since these treatments have relatively small effects on mortality from the aggregate of all other causes. Interpretation Some of the widely practicable adjuvant drug treatments that were being tested in the 1980s, which substantially reduced 5-year recurrence rates (but had somewhat less effect on 5-year mortality rates), also substantially reduce 15-year mortality rates. Further improvements in long-term survival could well be available from newer drugs, or better use of older drugs.
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- Ahmadian, Zahra, et al.
(author)
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New Attacks on UMTS Network Access
- 2009
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Conference paper (peer-reviewed)abstract
- In this paper we propose two new attacks on UMTS network. Both attacks exploit the UMTS-GSM interworking and are possible in the GSM access area of UMTS network. The first attack allows the attacker to eavesdrop on the entire traffic of the victim UMTS subscriber in the GERAN coverage of the UMTS network. The second attack is an impersonation attack i.e. the attacker impersonates a genuine UMTS subscriber to a UMTS network and fools the network to provide services at the expense of the victim subscriber in its GERAN coverage.
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- Azizi, Zahra, et al.
(author)
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How accurate is the CASPT2 method?
- 2006
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In: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9084 .- 1463-9076. ; 8:23, s. 2727-2732
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Journal article (peer-reviewed)abstract
- This paper is a reply to a recent paper on the isomers of trisulfur oxides (Chem. Commun., 2005, 3712) where the accuracy of the CASPT2 method is called in question. We illustrate that their results are due to an inadequate choice of active orbitals. Some results for related O and S containing molecules are also presented to strengthen the argumentation. It is concluded that the CASPT2 method is accurate to at least 0.1 eV (2 kcal mol(-1)) for this type of systems.
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- Cava, Felipe, et al.
(author)
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Control of the respiratory metabolism of Thermus thermophilus by the nitrate respiration conjugative element NCE
- 2007
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In: Molecular Microbiology. - : Wiley. - 0950-382X .- 1365-2958. ; 64:3, s. 630-646
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Journal article (peer-reviewed)abstract
- The strains of Thermus thermophilus that contain the nitrate respiration conjugative element (NCE) replace their aerobic respiratory chain by an anaerobic counterpart made of the Nrc-NADH dehydrogenase and the Nar-nitrate reductase in response to nitrate and oxygen depletion. This replacement depends on DnrS and DnrT, two homologues to sensory transcription factors encoded in a bicistronic operon by the NCE. DnrS is an oxygen-sensitive protein required in vivo to activate transcription on its own dnr promoter and on that of the nar operon, but not required for the expression of the nrc operon. In contrast, DnrT is required for the transcription of these three operons and also for the repression of nqo, the operon that encodes the major respiratory NADH dehydrogenase expressed during aerobic growth. Thermophilic in vitro assays revealed that low DnrT concentrations allows the recruitment of the T. thermophilus RNA polymerase sigma(A) holoenzyme to the nrc promoter and its transcription, whereas higher DnrT concentrations are required to repress transcription on the nqo promoter. In conclusion, our data show a complex autoinducible mechanism by which DnrT functions as the transcriptional switch that allows the NCE to take the control of the respiratory metabolism of its host during adaptation to anaerobic growth.
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Dynamic Positioning based on Voronoi Cells (DPVC)
- 2006. - 1
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Editorial collection (peer-reviewed)abstract
- In this paper we are proposing an approach for flexible positioning of players in Soccer Simulation in a Multi-Agent environment. We introduce Dynamic Positioning based on Voronoi Cells (DPVC) as a new method for players' positioning which uses Voronoi Diagram for distributing agents in the field. This method also uses Attraction Vectors that indicate agents' tendency to specific objects in the field with regard to the game situation and players' roles. Finally DPVC is compared with SBSP as the conventional method of positioning.
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- Ebrahimi, Zahra, et al.
(author)
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En hypotesgenererande studie av nattfastans längd, undernäring och hälsorelaterad livskvalitet hos äldre
- 2009
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In: Vård i Norden. - 0107-4083. ; 29:1, s. 45-48
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Journal article (peer-reviewed)abstract
- Malnutrition is a major problem among elderly at nursing homes. Overnight-fasting is defined as the time between the last mealtime at night and breakfast and was considered as long in this study when it exceeded eleven hours. The aim of the study was to map the overnight-fasting length, the frequency and rate of malnutrition and the health related quality of life in an elderly population living at a nursing home in western Sweden. The study was a quantitative descriptive study and was performed at a somatic department of a nursing home. The data was analysed using descriptive statistic. The result indicate a possible relation between the combination of manifest malnutrition as measured in this study, an overnight- fasting length exceeding 11 hours and low health related quality of life in old age. The study generated the hypothesis that health related quality of life among elderly persons living at nursing homes can increase if the over-night fasting length decrease under eleven hours. In addition there is a need for more knowledge concerning the elderly’ own experience of long over-night fasting.
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| 9. |
- El-Seedi, H, et al.
(author)
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Cyclopeptide alkaloids
- 2007
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In: Phytochemistry Reviews. - : Springer Science and Business Media LLC. - 1568-7767 .- 1572-980X. ; 6:1, s. 143-165
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Journal article (peer-reviewed)abstract
- In this review, we discuss cyclopeptide alkaloids, their plant origin, and the way of separation, spectral analysis done for structure elucidation, stereochemistry, and their biological activities. In addition, we discuss briefly the chemosystematic significance of the cyclopeptide alkaloids based on their discovery in the family Olacaceae.
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