| 1. |
- Zhang, Xiaoying, et al.
(författare)
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IL-6 Regulates MMP-10 Expression via JAK2/STAT3 Signaling Pathway in a Human Lung Adenocarcinoma Cell Line
- 2009
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Ingår i: Anticancer research. - 1791-7530. ; 29:11, s. 4497-4501
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Tidskriftsartikel (refereegranskat)abstract
- We previously reported that matrix metalloproteinase (MMP)-10 mRNA levels were significantly lower in tumor tissues than in adjacent normal tissues in human non-small cell lung cancer (NSCLC), whereas protein levels of MMP-10 were higher in the tumor tissues than the adjacent tissues. The mechanism of this divergence is still unknown. In the present stud), the role of Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) on interleukin (IL)-6 mediated regulation of MMP-10 expression was investigated in a human lung adenocarcinoma cell line (A549 cells) and the molecular regulatory mechanism of MMP-10 expression was explored. A549 cells were stimulated by different concentrations of IL-6 with or without AG490, a specific JAK2 inhibitor. It was demonstrated that IL-6 moderately reduced the MMP-10 mRNA levels, whereas it significantly enhanced the MMP-10 protein mass in the A549 cells. This phenomenon mimicked the divergence of mRNA level and protein mass of MMP-10 in human NSCLC. Moreover, the present study indicated that IL-6 regulation of MMP-10 expression was via the JAK2/STAT3 pathway. STAT3 mRNA levels were significantly increased when the cells were treated with IL-6, whereas when AG490 (50 mu M) was added to the cell cultures, IL-6-induced increase of STAT3 mRNA levels was abolished. Meanwhile, AG490 blocked the IL-6-induced inhibition of MMP-10 mRNA as well as blocking the IL-6-induced increase of MMP-10 protein mass in the A549 cells. Neither IL-6 nor AG490 influenced JAK2 mRNA levels in the A549 cell cultures. It is concluded that the JAK2/STAT3 pathway is involved in the IL-6-mediated regulation of MMP-10, and IL-6 can moderately reduce MMP-10 mRNA levels and strongly increase MMP-10 protein mass in human lung adenocarcinoma A549 cells. Contrasting effects of IL-6 on MMP-10 mRNA level and protein concentration in A549 cells may partially explain the divergence of MMP-10 mRNA level and protein mass in human NSCLC.
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| 2. |
- Huang, Xin, 1982-, et al.
(författare)
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Privacy of Value-Added Context-Aware Service Cloud
- 2009
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Ingår i: Lecture notes in computer science Volume 5931. - Berlin, Heidelberg : Springer. - 9783642106644 ; , s. 547-552
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Konferensbidrag (refereegranskat)abstract
- In the cloud computing era, service provider cloud and context service cloud store all your personal context data. This is a positive aspect for value-added context-aware service cloud as it makes that context information collection are easier than was the case previously. However, this computing environment does add a series of threats in relation to privacy protection. Whoever receives the context information is able to deduce the status of the owners and, generally owners are not happy to share this information. In this paper, we propose a privacy preserved framework which can be utilized by value-added context-aware service cloud. Context data and related services access privileges are determined by context-aware role-based access control (CRAC) extended from role-based access control (RAC). Privacy preserved context service protocol (PPCS) is designed to protect user privacy from exposed context information. Additionally, user network and information diffusion is combined to evaluate the privacy protection effect.
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| 3. |
- Anani, Adi, 1944-, et al.
(författare)
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QoS-guaranteed packet scheduling in wireless networks
- 2009
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Ingår i: The Journal of China Universities of Posts and Telecommunications. - Amsterdam : Elsevier. - 1005-8885. ; 16:2, s. 63-67
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Tidskriftsartikel (refereegranskat)abstract
- To guarantee the quality of service (QoS) of a wireless network, a new packet scheduling algorithm using cross-layer design technique is proposed in this article. First, the demand of packet scheduling for multimedia transmission in wireless networks and the deficiency of the existing packet scheduling algorithms are analyzed. Then the model of the QoS-guaranteed packet scheduling (QPS) algorithm of high speed downlink packet access (HSDPA) and the cost function of packet transmission are designed. The calculation method of packet delay time for wireless channels is expounded in detail, and complete steps to realize the QPS algorithm are also given. The simulation results show that the QPS algorithm that provides the scheduling sequence of packets with calculated values can effectively improve the performance of delay and throughput.
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| 4. |
- Bousquet, J, et al.
(författare)
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Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the improving asthma control trial
- 2005
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 1365-2222. ; 35:6, s. 723-727
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Tidskriftsartikel (refereegranskat)abstract
- Background Inadequately controlled allergic rhinitis (AR) in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. We assessed asthma-related medical resource use and attacks in asthmatic patients who did and did not have concomitant AR and were adding montelukast or salmeterol to baseline treatment with inhaled. fluticasone. Methods A post hoc resource use analysis of a 52-week, double-blind multicentre clinical trial (IMPACT: IMProving Asthma Control Trial) including 1490 adults with chronic asthma, aged 15 72 years, with FEV1 50-90% of predicted and >= 12% increase in FEV1 after salbutamol administration, treated with either montelukast 10mg daily or salmeterol 50 mu g twice daily in addition to. fluticasone 200 mg, was undertaken. Asthma- related medical resource use included medical visits ( defined as either an unscheduled visit [to a general practitioner, a specialist or a nonmedical provider] or a specialist visit), emergency room visits and hospitalizations during follow-up. Asthma attacks were defined as the worsening of asthma requiring unscheduled visit, emergency visit, hospitalization or oral/intravenous/intramuscular corticosteroids. Results A self-reported history of concomitant AR was identified in 60% of the patients (n=893). Univariate analysis suggests that significantly more patients with concomitant AR experienced emergency room visits (3.6% vs. 1.7%, P=0.029) and asthma attacks (21.3% vs. 17.1%, P=0.046). Multivariate analysis adjusting for treatment group, age and baseline asthma severity confirmed these results since the presence of concomitant AR in patients with asthma increases the likelihood of emergency room visit ( odds ratio ( OR) 52.35, 95% confidence interval (CI) = 1.12 - 4.80) and asthma attack (OR = 1.35, 95% CI = 1.03 - 1.77). Patients with asthma alone compared with patients with both conditions did not differ in terms of unscheduled or specialist visits and hospitalizations. Conclusions Presence of self-reported concomitant AR in patients with asthma resulted in a higher rate of asthma attacks and more emergency room visits compared with asthma patients without concomitant AR.
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| 5. |
- Dong, N., et al.
(författare)
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Spectroscopic analysis of LiKGdF5 : Er3+, Sm3+ single crystal
- 2006
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Ingår i: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 424:1-2, s. 334-337
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Tidskriftsartikel (refereegranskat)abstract
- Low temperature photoluminescence spectra were measured under the selective excitation to the energy levels of Gd3+,Er3+ and Sm3+, respectively. Corresponding transitions were assigned with the help of fluorescence decay measurements. By assuming that the rare earth ion is in C-2v symmetry instead of the actual C-2, crystal field calculations were carried out based on the deduced experimental energy level data of Er3+ and Sm3+. The theoretical result is in good agreement with the experimental data.
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| 6. |
- Gu, B., et al.
(författare)
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Low-cost high-performance fiber-optic pH sensor based on thin-core fiber modal interferometer
- 2009
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Ingår i: Optics Express. - 1094-4087. ; 17:25, s. 22296-22302
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Tidskriftsartikel (refereegranskat)abstract
- A new fiber-optic pH sensor based on a thin-core fiber modal interferometer with electrostatic self-assembled nanocoating is presented. After inserting a segment of thin-core fiber into a standard single-mode fiber, high-order cladding modes are excited and interfere with the core mode to form an in-fiber modal interferometer. The side surface of the sensor is then deposited with poly(allylamine hydrochloride) and poly(acrylic acid) nanocoating by electrostatic self-assembly technique. A fast and linear response is obtained in either acid or alkali solution (in the pH range 2.5 to 10) with resolution of 0.013 pH unit.
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| 7. |
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| 8. |
- Orrú, Valeria, et al.
(författare)
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A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus
- 2009
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 18:3, s. 569-579
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Tidskriftsartikel (refereegranskat)abstract
- A gain-of-function R620W polymorphism in the PTPN22 gene, encoding the lymphoid tyrosine phosphatase LYP, has recently emerged as an important risk factor for human autoimmunity. Here we report that another missense substitution (R263Q) within the catalytic domain of LYP leads to reduced phosphatase activity. High-resolution structural analysis revealed the molecular basis for this loss of function. Furthermore, the Q263 variant conferred protection against human systemic lupus erythematosus, reinforcing the proposal that inhibition of LYP activity could be beneficial in human autoimmunity.
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| 9. |
- Samii, Soheil, et al.
(författare)
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Immune Genetic Algorithms for Optimization of Task Priorities and FlexRay Frame Identifiers
- 2009
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Ingår i: <em>Intl. Conference on Embedded and Real-Time Computing Systems and Applications (RTCSA), Beijing, China, August 24-26, 2009.</em>. - : IEEE COMPUTER SOC. - 9780769537870 ; , s. 486-493
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Konferensbidrag (refereegranskat)abstract
- FlexRay is an automotive communication protocol that combines the comprehensive time-triggered paradigm with an adaptive phase that is more suitable for event-based communication. We study optimization of average response times by assigning priorities and frame identifiers to tasks and messages. Our optimization approach is based on immune genetic algorithms, where in addition to the crossover and mutation operators, we use a vaccination operator that results in considerable improvements in optimization time and quality.
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| 10. |
- Vinel, Alexey, 1983-, et al.
(författare)
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Performance Analysis of the Random Access in IEEE 802.16
- 2005
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Ingår i: IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, PIMRC. - New York, USA : IEEE Press. - 9783800729098 ; , s. 1596-1600
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Konferensbidrag (refereegranskat)abstract
- Recently, the IEEE has standardized the 802.16 protocol for metropolitan broadband wireless access systems. According to the standard, therandom access scheme based on the slotted binary exponential backoff algorithm is used in this system for initial ranging and bandwidth requests transmission. This paper provides both the simulation and analytical models for the investigation of the random access in IEEE 802.16. Based on the assumption of finite number of subscriber stations and ideal channel conditions the delay is evaluated for varying number of transmission opportunities and different backoff window sizes. © 2005 IEEE.
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