| 1. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 2. |
- Chen, Hui, et al.
(författare)
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Characterization of insolubilized humic acid and its sorption behaviors
- 2009
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Ingår i: Environmental Geology. - : Springer Science and Business Media LLC. - 0943-0105 .- 1432-0495. ; 57:8, s. 1847-1853
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Tidskriftsartikel (refereegranskat)abstract
- Insolubilized humic acid (IHA) was prepared in the laboratory by heating approach. Through the comparison between the endothermic peaks, optimal heating temperature was determined to be 330A degrees C. The modified IHA then was characterized by TG-DTA, SEM, FTIR, element analysis, and nitrogen adsorption-desorption isotherms. The removal efficiency of p-nitrophenol from the aqueous solution by adsorption onto solid IHA surfaces was shown to be a function of pH, reaction temperature, and p-nitrophenol concentration. Adsorption equilibrium data satisfactorily fitted the Langmuir adsorption isotherm. Under a certain concentration range, the removal rate of p-nitrophenol at pH 3.5 could reach 24, 29, and 35 mg/g at a temperature of 25, 35, and 45 +/- 0.1A degrees C. The results suggest that IHA could play a role as a potential efficient absorbent to remove organic contaminants, e.g., utilized to purify water contaminated by organic compounds.
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| 3. |
- Chenine, Moustafa, et al.
(författare)
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Survey on Priorities and Communication Requirements for PMU-based Applications in the Nordic Region
- 2009
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Ingår i: 2009 IEEE Bucharest PowerTech. - : IEEE. - 9781424422340 ; , s. 1183-1190
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Konferensbidrag (refereegranskat)abstract
- Phasor based Wide Area Monitoring and Control Systems (WAMC) promise to offer more accurate and timely data on the state of the power system, thus, increasing the possibilities to manage the system at a more efficient and responsive level and apply wide area control and protection schemes. This paper presents results of a survey on communications and technical requirements for applications based on Phasor Measurement Units (PMU). The survey was carried out in the Nordic Region with participants from Transmission System Operators (TSOs) and researchers. The survey focused on documenting the stage of research and development among TSOs and researchers in the Nordic Region, as well as, their plans and visions for the future. This includes planned PMU deployments and prioritization of PMU based applications. Furthermore, a significant part of the survey was an elicitation of communication requirements for applications based on PMU data. In the paper, an examination of the time requirements for these applications in terms of delays and samples per second and comparison similar published specifications is provided.
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| 4. |
- Franke, Ulrik, et al.
(författare)
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Enterprise Architecture analysis using Fault Trees and MODAF
- 2009
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Ingår i: Proceedings of the Forum at the CAiSE 2009 Conference. ; , s. 61-66
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Konferensbidrag (refereegranskat)abstract
- Analysis of dependencies between information systems, business processes, and strategic goals is an important part of the discipline of Enterprise Architecture (EA). However, EA models typically provide only visual and qualitative decision support. This paper shows how EA frameworks for dependency analysis can be extended into the realm of quantitative methods by the use of techniques from Fault Tree Analysis (FTA). Using MODAF, the UK Ministry of Defence Architecture Framework as an example, we give a list of criteria for the extraction of a metamodel for FTA use, and provide such a metamodel for MODAF. Furthermore, we use this MODAF FTA metamodel to perform dependency analysis on a sample MODAF model.
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| 5. |
- Fu, Hongyan, et al.
(författare)
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Tunable all-optical microwave notch filter with a negative tap based on a semiconductor optical amplifier and a dispersive medium
- 2009
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Ingår i: Optics and Laser Technology. - : Elsevier BV. - 0030-3992 .- 1879-2545. ; 41:3, s. 213-216
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Tidskriftsartikel (refereegranskat)abstract
- A tunable all-optical microwave notch filter with a negative tap based on a semiconductor optical amplifier and a dispersive medium is demonstrated. A negative tap is realized through the cross gain modulation in the semiconductor optical amplifier. The free spectrum range of the notch filter can be tuned by tuning the wavelength of one of the two laser sources. The influence of the amplitude mismatch of the two lasers on the performance of the filter is analyzed. The present notch filter is easy to implement and cost-effective.
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| 6. |
- He, Shu, et al.
(författare)
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A global assay of haemostasis which uses recombinant tissue factor and tissue-type plasminogen activator to measure the rate of fibrin formation and fibrin degradation in plasma
- 2007
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Ingår i: Thrombosis and Haemostasis. - 0340-6245 .- 2567-689X. ; 98:4, s. 871-882
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Tidskriftsartikel (refereegranskat)abstract
- The global assay of Overall Haemostasis Potential we previously described has been refined. The coagulation cascade in platelet-poor plasma is triggered by adding a minimal dose of recombinant tissue factor together with purified phospholipids and calcium; fibrinolysis is initiated by adding recombinant tissue type-plasminogen activator in a concentration similar to what can be obtained during thrombolysis. Numerical differentials of optical densities reflecting rates of fibrin formation and degradation are calculated by a new software, and the Coagulation Profile (Cp) and the Fibrinolysis Profile (Fp) are determined. The combined effect of these counteractive systems is expressed as a ratio of Cp to Fp, called the Overall Haemostasis Index. Commercially available coagulant-deficient patient plasma samples and plasma with various amounts of added PAI-1 are examined; changes of fibrin turbidity demonstrate that this assay can determine Cp and Fp in a physiologically relevant way. Increased Cp and decreased Fp in prothrombotic patients, as well as expected effects of heparin or a thrombin inhibitor on Cp and Fp, suggest that our method can detect hypercoagulability and assist in monitoring antithrombotic treatment. Ongoing studies will show whether this simple assay can be of value in clinical routine.
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| 7. |
- Zhu, Kun, et al.
(författare)
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A Simple and Tunable Single-Bandpass Microwave Photonic Filter of Adjustable Shape
- 2008
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Ingår i: IEEE Photonics Technology Letters. - 1041-1135 .- 1941-0174. ; 20:21-24, s. 1917-1919
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Tidskriftsartikel (refereegranskat)abstract
- A simple and tunable single-hand pass microwave photonic filter of adjustable shape is proposed and experimentally demonstrated. The filter is based on multiple sources (spectrum-sliced by a Mach-Zehnder interferometer) and two cascaded incoherent optical structures, namely, a dispersion medium of 50-km single-mode fiber and a fiber ring delay line. In the experimental range from 1.0 to 3.8 GHz, a discretely tunable single-hand pass filter with a high Q-factor or a flat-top response is achieved by carefully matching the transfer functions of the two individual optical structures.
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| 8. |
- Zhu, Kun, et al.
(författare)
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Application and analysis of Optimum PMU Placement methods with application to State Estimation Accuracy
- 2009
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Ingår i: 2009 IEEE POWER & ENERGY SOCIETY GENERAL MEETING, VOLS 1-8. - New York : IEEE. - 9781424442409 ; , s. 580-586
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Konferensbidrag (refereegranskat)abstract
- Phasor measurement units (PMU) coupled with high speed and bandwidth communication infrastructure holds great promise for future power system control and operation. The geographic location of the PMUs within the power system naturally affects the value added by PMUs to one specific application in power grid control and operation. Optimization of placement has been the subject of much analysis and research. This paper compares one PMU placement method targeting enhancement of state estimation accuracy with the current PMU deployment method utilized in Svenska Kraftnat (SvK), the Swedish Transmission System Operator. The possible estimation improvement applying this optimum placement algorithm is further studied while more PMUs are involved. Considering that the deployment of PMUs within SvK's grid is still limited, the study has been performed in a simulation environment. The paper contains a brief description of the simulation platform and the assumptions made during the work as well. The analysis shows that there are considerable gains to be made in estimator accuracy if the PMUs are placed in accordance with this method when compared to the current placement strategy. It could also be observed when the PMU monitored buses reaches a certain number in the entire network, the further introduction of phasor measurements will not be as effective in estimation accuracy improvement.
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