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Depicting the compo...
Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography
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Deschasaux, M. (författare)
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Bouter, K. E. (författare)
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Prodan, A. (författare)
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visa fler...
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Levin, E. (författare)
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Groen, A. K. (författare)
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Herrema, H. (författare)
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- Tremaroli, Valentina, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Bakker, G. J. (författare)
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Attaye, I. (författare)
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Pinto-Sietsma, S. J. (författare)
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van Raalte, D. H. (författare)
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Snijder, M. B. (författare)
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Nicolaou, M. (författare)
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Peters, R. (författare)
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Zwinderman, A. H. (författare)
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- Bäckhed, Fredrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Nieuwdorp, Max (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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visa färre...
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(creator_code:org_t)
- 2018-08-27
- 2018
- Engelska.
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 24:10, s. 1526-31
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Trillions of microorganisms inhabit the human gut and are regarded as potential key factors for health(1,2). Characteristics such as diet, lifestyle, or genetics can shape the composition of the gut microbiota(2-6) and are usually shared by individuals from comparable ethnic origin. So far, most studies assessing how ethnicity relates to the intestinal microbiota compared small groups living at separate geographical locations(7-10). Using fecal 16S ribosomal RNA gene sequencing in 2,084 participants of the Healthy Life in an Urban Setting (HELIUS) study(11,12), we show that individuals living in the same city tend to share similar gut microbiota characteristics with others of their ethnic background. Ethnicity contributed to explain the interindividual dissimilarities in gut microbiota composition, with three main poles primarily characterized by operational taxonomic units (OTUs) classified as Prevotella (Moroccans, Turks, Ghanaians), Bacteroides (African Surinamese, South-Asian Surinamese), and Clostridiales (Dutch). The Dutch exhibited the greatest gut microbiota alpha-diversity and the South-Asian Surinamese the smallest, with corresponding enrichment or depletion in numerous OTUs. Ethnic differences in alpha-diversity and interindividual dissimilarities were independent of metabolic health and only partly explained by ethnic-related characteristics including sociodemographic, lifestyle, or diet factors. Hence, the ethnic origin of individuals may be an important factor to consider in microbiome research and its potential future applications in ethnic-diverse societies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- glucose-metabolism
- enterotypes
- diversity
- disease
- health
- genetics
- markers
- diet
- age
- Biochemistry & Molecular Biology
- Cell Biology
- Research & Experimental
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Deschasaux, M.
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Bouter, K. E.
-
Prodan, A.
-
Levin, E.
-
Groen, A. K.
-
Herrema, H.
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visa fler...
-
Tremaroli, Valen ...
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Bakker, G. J.
-
Attaye, I.
-
Pinto-Sietsma, S ...
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van Raalte, D. H ...
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Snijder, M. B.
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Nicolaou, M.
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Peters, R.
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Zwinderman, A. H ...
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Bäckhed, Fredrik ...
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Nieuwdorp, Max
-
visa färre...
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Nature Medicine
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Göteborgs universitet