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Dysregulated Lipid ...
Dysregulated Lipid Metabolism Precedes Onset of Psychosis
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- Dickens, Alex M. (författare)
- Turku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland
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- Sen, Partho (författare)
- Turku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland
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- Kempton, Matthew J. (författare)
- Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
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- Barrantes-Vidal, Neus (författare)
- Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Fundació Sanitària Sant Pere Claver, Spanish Mental Health Research Network, Barcelona, Spain
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- Iyegbe, Conrad (författare)
- Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
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- Nordentoft, Merete (författare)
- Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen, Glostrup, Denmark
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- Pollak, Thomas (författare)
- Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
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- Riecher-Rössler, Anita (författare)
- University Psychiatric Hospital, Basel, Switzerland
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- Ruhrmann, Stephan (författare)
- Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
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- Sachs, Gabriele (författare)
- Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
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- Bressan, Rodrigo (författare)
- Lab Interdisciplinar Neurociências Clínicas, Departimento Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
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- Krebs, Marie-Odile (författare)
- University of Paris, Groupe Hospitalier Universitaire Paris Sainte-Anne, Centre d'Évaluation Pour Jeunes Adultes et Adolescents, Institut National de la Santé et de la Recherche Médicale, Institut de Psychiatrie, Paris, France
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- Amminger, G. Paul (författare)
- Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
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- de Haan, Lieuwe (författare)
- Department of Psychiatry, Amsterdam University Medical Center, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands
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- van der Gaag, Mark (författare)
- Department of Clinical Psychology and EMGO+ Institute for Health and Care Research, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands; Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands
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- Valmaggia, Lucia (författare)
- Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland
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- McGuire, Philip (författare)
- Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 89:3, s. 288-297
- Relaterad länk:
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https://doi.org/10.1...
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http://www.biologica...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group.METHODS: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes.RESULTS: At baseline, compared with control subjects, CHR subjects (independent of outcome) had higher levels of triacylglycerols with a low acyl carbon number and a double bond count, as well as higher levels of lipids in general. CHR subjects who subsequently developed psychosis (n = 50) were distinguished from those that did not (n = 213) on the basis of lipid profile at baseline using a model with an area under the receiver operating curve of 0.81 (95% confidence interval = 0.69-0.93). CHR subjects who became psychotic had lower levels of ether phospholipids than CHR individuals who did not (p < .01).CONCLUSIONS: Collectively, these data suggest that lipidomic abnormalities predate the onset of psychosis and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- At-risk mental state
- Clinical high risk for psychosis
- Lipid metabolism
- Lipidomics
- Mass spectrometry
- Schizophrenia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Dickens, Alex M.
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Sen, Partho
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Kempton, Matthew ...
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Barrantes-Vidal, ...
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Iyegbe, Conrad
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Nordentoft, Mere ...
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visa fler...
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Pollak, Thomas
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Riecher-Rössler, ...
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Ruhrmann, Stepha ...
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Sachs, Gabriele
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Bressan, Rodrigo
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Krebs, Marie-Odi ...
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Amminger, G. Pau ...
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de Haan, Lieuwe
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van der Gaag, Ma ...
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Valmaggia, Lucia
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Hyötyläinen, Tuu ...
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Oresic, Matej, 1 ...
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McGuire, Philip
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- MEDICIN OCH HÄLSOVETENSKAP
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Biological Psych ...
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Örebro universitet