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- Aksimsek, Sinan, et al.
(författare)
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TEM wave scattering by a step discontinuity on the outer wall of a coaxial waveguide
- 2013
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Ingår i: IEEE transactions on microwave theory and techniques. - : IEEE Press. - 0018-9480 .- 1557-9670. ; 61:8, s. 2783-2791
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, the propagation of TEM waves along a coaxial waveguide with a step discontinuity on its outer wall is investigated rigorously by applying the direct Fourier transform and reducing the problem into the solution of a modified Wiener–Hopf equation. The solution for the field terms are determined in terms of an infinite number of unknown coefficients, which satisfy an infinite set of linear algebraic equations. These equations are solved numerically and the effect of area ratio is presented graphically at the end of the analysis. The same problem is also analyzed by applying the mode-matching technique and the results of the two approaches are compared. It is observed numerically that the Wiener–Hopf technique provides a better convergence than the mode-matching technique.
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- Bayford, Richard H., et al.
(författare)
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Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography
- 2022
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Ingår i: IEEE Transactions on Biomedical Engineering. - : IEEE. - 0018-9294 .- 1558-2531. ; 69:1, s. 494-502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: An imaging device to locate functionalised nanoparticles, whereby therapeutic agents are transported from the site of administration specifically to diseased tissues, remains a challenge for pharmaceutical research. Here, we show a new method based on electrical impedance tomography (EIT) to provide images of the location of gold nanoparticles (GNPs) and the excitation of GNPs with radio frequencies (RF) to change impedance permitting an estimation of their location in cell models Methods: We have created an imaging system using quantum cluster GNPs as contrast agent, activated with RF fields to heat the functionalized GNPs, which causes a change in impedance in the surrounding region. This change is then identified with EIT. Results: Images of impedance changes of around 80 ± 4% are obtained for a sample of citrate stabilized GNPs in a solution of phosphate-buffered saline. A second quantification was carried out using colorectal cancer cells incubated with culture media, and the internalization of GNPs into the colorectal cancer cells was undertaken to compare them with the EIT images. When the cells were incubated with functionalised GNPs, the change was more apparent, approximately 40 ± 2%. This change was reflected in the EIT image as the cell area was more clearly identifiable from the rest of the area. Significance: EIT can be used as a new method to locate functionalized GNPs in human cells and help in the development of GNP-based drugs in humans to improve their efficacy in the future.
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- Becher, Tobias H., et al.
(författare)
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Prolonged Continuous Monitoring of Regional Lung Function in Infants with Respiratory Failure
- 2022
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Ingår i: Annals of the American Thoracic Society. - : American Thoracic Society. - 2329-6933 .- 2325-6621. ; 19:6, s. 991-999
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Electrical impedance tomography (EIT) allows instantaneous and continuous visualization of regional ventilation and changes in end-expiratory lung volume at the bedside. There is particular interest in using EIT for monitoring in critically ill neonates and young children with respiratory failure. Previous studies have focused only on short-term monitoring in small populations. The feasibility and safety of prolonged monitoring with EIT in neonates and young children have not been demonstrated yet.Objectives: To evaluate the feasibility and safety of long-term EIT monitoring in a routine clinical setting and to describe changes in ventilation distribution and homogeneity over time and with positioning in a multicenter cohort of neonates and young children with respiratory failure.Methods: At four European University hospitals, we conducted an observational study (NCT02962505) on 200 patients with postmenstrual ages (PMA) between 25 weeks and 36 months, at risk for or suffering from respiratory failure. Continuous EIT data were obtained using a novel textile 32-electrode interface and recorded at 48 images/s for up to 72 hours. Clinicians were blinded to EIT images during the recording. EIT parameters and the effects of body position on ventilation distribution were analyzed offline. Results: The average duration of FAT measurements was 53 +/- 20 hours. Skin contact impedance was sufficient to allow image reconstruction for valid ventilation analysis during a median of 92% (interquartile range, 77-98%) of examination time. EIT examinations were well tolerated, with minor skin irritations (temporary redness or imprint) occurring in 10% of patients and no moderate or severe adverse events. Higher ventilation amplitude was found in the dorsal and right lung areas when compared with the ventral and left regions, respectively. Prone positioning resulted in an increase in the ventilation-related EIT signal in the dorsal hemithorax, indicating increased ventilation of the dorsal lung areas. Lateral positioning led to a redistribution of ventilation toward the dependent lung in preterm infants and to the nondependent lung in patients with PMA > 37 weeks.Conclusions: EIT allows continuous long-term monitoring of regional lung function in neonates and young children for up to 72 hours with minimal adverse effects. Our study confirmed the presence of posture-dependent changes in ventilation distribution and their dependency on PMA in a large patient cohort.
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| 8. |
- Dalarsson, Mariana, et al.
(författare)
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Absorption and optimal plasmonic resonances for small ellipsoidal particles in lossy media
- 2017
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Ingår i: Journal of Physics D. - : Institute of Physics (IOP). - 0022-3727 .- 1361-6463. ; 50:34
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Tidskriftsartikel (refereegranskat)abstract
- A new simplified formula is derived for the absorption cross section of small dielectric ellipsoidal particles embedded in lossy media. The new expression leads directly to a closed form solution for the optimal conjugate match with respect to the surrounding medium, i.e. the optimal permittivity of the ellipsoidal particle that maximizes the absorption at any given frequency. This defines the optimal plasmonic resonance for the ellipsoid. The optimal conjugate match represents a metamaterial in the sense that the corresponding optimal permittivity function may have negative real part (inductive properties), and can not in general be implemented as a passive material over a given bandwidth. A necessary and sufficient condition is derived for the feasibility of tuning the Drude model to the optimal conjugate match at a single frequency, and it is found that all the prolate spheroids and some of the (not too flat) oblate spheroids can be tuned into optimal plasmonic resonance at any desired center frequency. Numerical examples are given to illustrate the analysis. Except for the general understanding of plasmonic resonances in lossy media, it is also anticipated that the new results can be useful for feasibility studies with e.g. the radiotherapeutic hyperthermia based methods to treat cancer based on electrophoretic heating in gold nanoparticle suspensions using microwave radiation.
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| 10. |
- Dalarsson, Mariana, et al.
(författare)
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TE-wave propagation in a graded waveguide structure
- 2018
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Ingår i: 2018 12th International Congress on Artificial Materials for Novel Wave Phenomena (Metamaterials). - : IEEE. - 9781538647028 - 9781538647035 - 9781538647011 ; , s. 93-95
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Konferensbidrag (refereegranskat)abstract
- We investigate TE-wave propagation in a hollow waveguide with a graded dielectric barrier, using an equivalent model of the waveguide filled with a stratified medium. General formulae for the electric field components of the TE-waves, applicable to hollow waveguides with arbitrary cross sectional shapes, are presented. As an illustration, we obtain the exact analytical results for the electric field components in a rectangular waveguide, as well as the exact analytical results for reflection and transmission coefficients which are valid for waveguides of arbitrary cross sectional shapes.
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