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Sökning: db:Swepub > Uppsala universitet > Ahlström Håkan > Westlin Jan Erik

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1.
  • Nilsson, Sten, et al. (författare)
  • Positron emission tomography (PET) with 11C-5-hydroxytryptophan (5-HTP) in patients with metastatic hormone-refractory prostatic adenocarcinoma
  • 1997
  • Ingår i: Nuclear Medicine and Biology. - 0969-8051. ; 24:4, s. 319-325
  • Tidskriftsartikel (refereegranskat)abstract
    • The discovery of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma has opened a potentially new therapeutic approach in this group of patients with a poor prognosis and few effective therapy modalities. Based on previous findings of increased uptake of 11C-5-hydroxytryptophan (11C-5-HTP) in neuroendocrine tumours using the PET technique, this tracer was applied in the study of 10 patients with metastatic hormone-refractory prostatic adenocarcinoma. In three patients, the study was repeated after treatment. An increased uptake of 11C-5-HTP was observed in all investigated skeletal lesions, although the magnitude of the uptake was moderate. The difference between the standard uptake values (SUV) in normal bone and metastatic lesions was significant (p < 0.001). A kinetic analysis of the uptake of 11C-5-HTP demonstrates an increase during the first minutes followed by a wash-out and a stabilization of the tissue/blood ratio at about 2. The Patlak plots demonstrated a gradual increase in the transport rate during the first 20 to 30 min, after which a constant level was observed. The SUV varied between patients and between lesions over time and treatment. The uptake of 11C-5-HTP discriminates metastatic lesions from normal bone and may thus aid in the diagnosis and, potentially, in treatment monitoring of metastatic hormone-refractory prostatic adenocarcinoma. Uptake kinetics are characterized by a wash-out and cannot alone be used as proof of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma.
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3.
  • Westlin, Jan-Erik, et al. (författare)
  • Somatostatin receptor scintigraphy of carcinoid tumours using the [111In-DTPA-D-Phe1]-octreotide
  • 1993
  • Ingår i: Acta Oncologica. - 0284-186X. ; 32:7-8, s. 783-786
  • Tidskriftsartikel (refereegranskat)abstract
    • Somatostatin-receptor scintigraphy using the 111In-labelled somatostatin-analogue octreotide ([111In-DTPA-D-Phe1]-octreotide) was performed in 40 patients with carcinoid tumours. In 31/40 patients, this scintigraphy proved positive compared with the 33/40 patients whose tumours were disclosed on CT scans. In addition, 18 previously unidentified lesions were detected with this scintigraphy. Two of these lesions represented previously undetectable primary tumours. It is concluded that somatostatin receptor scintigraphy using [111In-DTPA-D-Phe1]-octreotide has a future role in the staging of patients with carcinoid disease.
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4.
  • Westlin, Jan-Erik, et al. (författare)
  • Three-dimensional OctreoScan111 SPECT of abdominal manifestation of neuroendocrine tumours
  • 1993
  • Ingår i: Acta Oncologica. - 0284-186X. ; 32:2, s. 171-176
  • Tidskriftsartikel (refereegranskat)abstract
    • In the present study we have investigated the three-dimensional (3D) reconstruction of OctreoScan111 SPECT (single photon emission tomography) images in 20 patients with neuroendocrine tumours. All patients had at least 2 tumour lesions as assessed from computerized tomography (CT) and SPECT. The 3D rendering was performed using a software, which produces images by implementing direct rendering from voxels without an intermediate surface data structure. The software has options for a free choice of thresholding and possibilities of clipping in coronal, transversal and sagittal planes. The results obtained showed that 3D reconstruction with volume rendering (3Dvr) gave a superior topographical localization of tumour uptakes when compared with SPECT. The 3Dvr technique was also combined with transversal clipping in rendered volumes (3Dvr+c). The major advantage with the 3Dvr+c technique was found to be an improved visualization of anatomical references as well as improved diagnostic information in a particular, selected, transversal slice, thus facilitating the identification and comparison of individual tumour lesions.
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