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Träfflista för sökning "db:Swepub ;srt2:(2010-2011);pers:(Riboli Elio);pers:(Bingham Sheila);pers:(Boffetta Paolo);pers:(Martínez Carmen);pers:(Tumino Rosario)"

Sökning: db:Swepub > (2010-2011) > Riboli Elio > Bingham Sheila > Boffetta Paolo > Martínez Carmen > Tumino Rosario

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1.
  • Eussen, Simone JPM, et al. (författare)
  • Plasma folate, related genetic variants, and colorectal cancer risk in EPIC
  • 2010
  • Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965. ; 19:5, s. 1328-1340
  • Tidskriftsartikel (refereegranskat)abstract
    • Findings of the present study tend to weaken the evidence that folate plays an important role in CRC carcinogenesis. However, larger sample sizes are needed to adequately address potential gene-environment interactions.
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2.
  • Eussen, Simone JPM, et al. (författare)
  • Plasma Vitamins B2, B6, and B12, and Related Genetic Variants as Predictors of Colorectal Cancer Risk
  • 2010
  • Ingår i: Cancer Epidemiology, Biomarkers & Prevention. - American Association for Cancer Research. - 1055-9965. ; 19:10, s. 2549-2561
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: B-vitamins are essential for one-carbon metabolism and have been linked to colorectal cancer. Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive. Methods: We carried out a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, including 1,365 incident colorectal cancer cases and 2,319 controls matched for study center, age, and sex. We measured the sum of B2 species riboflavin and flavin mononucleotide, and the sum of B6 species pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for colorectal cancer were estimated using conditional logistic regression, adjusted for smoking, education, physical activity, body mass index, alcohol consumption, and intakes of fiber and red and processed meat. Results: The relative risks comparing highest to lowest quintile were 0.71 95% confidence interval (95% CI), 0.56-0.91; P-trend = 0.02 for vitamin B2, 0.68 (95% CI, 0.53-0.87; P-trend <0.001) for vitamin B6, and 1.02 (95% CI, 0.80-1.29; P-trend = 0.19) for vitamin B12. The associations for vitamin B6 were stronger in males who consumed >= 30 g alcohol/day. The polymorphisms were not associated with colorectal cancer. Conclusions: Higher plasma concentrations of vitamins B2 and B6 are associated with a lower colorectal cancer risk. Impact: This European population-based study is the first to indicate that vitamin B2 is inversely associated with colorectal cancer, and is in agreement with previously suggested inverse associations of vitamin B6 with colorectal cancer. Cancer Epidemiol Biomarkers Prev; 19(10); 2549-61. (C) 2010 AACR.
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3.
  • Hermann, Silke, et al. (författare)
  • Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition
  • 2010
  • Ingår i: Journal of Cancer Research and Clinical Oncology. - Springer. - 0171-5216. ; 136:1, s. 71-77
  • Tidskriftsartikel (refereegranskat)abstract
    • Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases 1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL) were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02-1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27-0.79) versus lowest educational level. No association was found for HL. We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded.
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