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helena pedersen
 

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Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Gretarsdottir, Solveig (author)
Baas, Annette F. (author)
Thorleifsson, Gudmar (author)
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Holm, Hilma (author)
den Heijer, Martin (author)
de Vries, Jean-Paul P. M. (author)
Kranendonk, Steef E. (author)
Zeebregts, Clark J. A. M. (author)
van Sterkenburg, Steven M. (author)
Geelkerken, Robert H. (author)
van Rij, Andre M. (author)
Williams, Michael J. A. (author)
Boll, Albert P. M. (author)
Kostic, Jelena P. (author)
Jonasdottir, Adalbjorg (author)
Jonasdottir, Aslaug (author)
Walters, G. Bragi (author)
Masson, Gisli (author)
Sulem, Patrick (author)
Saemundsdottir, Jona (author)
Mouy, Magali (author)
Magnusson, Kristinn P. (author)
Tromp, Gerard (author)
Elmore, James R. (author)
Sakalihasan, Natzi (author)
Limet, Raymond (author)
Defraigne, Jean-Olivier (author)
Ferrell, Robert E. (author)
Ronkainen, Antti (author)
Ruigrok, Ynte M. (author)
Wijmenga, Cisca (author)
Grobbee, Diederick E. (author)
Shah, Svati H. (author)
Granger, Christopher B. (author)
Quyyumi, Arshed A. (author)
Vaccarino, Viola (author)
Patel, Riyaz S. (author)
Zafari, A. Maziar (author)
Levey, Allan I. (author)
Austin, Harland (author)
Girelli, Domenico (author)
Pignatti, Pier Franco (author)
Olivieri, Oliviero (author)
Martinelli, Nicola (author)
Malerba, Giovanni (author)
Trabetti, Elisabetta (author)
Becker, Lewis C. (author)
Becker, Diane M. (author)
Reilly, Muredach P. (author)
Rader, Daniel J. (author)
Mueller, Thomas (author)
Dieplinger, Benjamin (author)
Haltmayer, Meinhard (author)
Urbonavicius, Sigitas (author)
Lindblad, Bengt (author)
Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
Gottsäter, Anders (author)
Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
Gaetani, Eleonora (author)
Pola, Roberto (author)
Wells, Philip (author)
Rodger, Marc (author)
Forgie, Melissa (author)
Langlois, Nicole (author)
Corral, Javier (author)
Vicente, Vicente (author)
Fontcuberta, Jordi (author)
Espana, Francisco (author)
Grarup, Niels (author)
Jorgensen, Torben (author)
Witte, Daniel R. (author)
Hansen, Torben (author)
Pedersen, Oluf (author)
Aben, Katja K. (author)
de Graaf, Jacqueline (author)
Holewijn, Suzanne (author)
Folkersen, Lasse (author)
Karolinska Institutet
Franco-Cereceda, Anders (author)
Karolinska Institutet
Eriksson, Per (author)
Karolinska Institutet
Collier, David A. (author)
Stefansson, Hreinn (author)
Steinthorsdottir, Valgerdur (author)
Rafnar, Thorunn (author)
Valdimarsson, Einar M. (author)
Magnadottir, Hulda B. (author)
Sveinbjornsdottir, Sigurlaug (author)
Olafsson, Isleifur (author)
Magnusson, Magnus Karl (author)
Palmason, Robert (author)
Haraldsdottir, Vilhelmina (author)
Andersen, Karl (author)
Onundarson, Pall T. (author)
Thorgeirsson, Gudmundur (author)
Kiemeney, Lambertus A. (author)
Powell, Janet T. (author)
Carey, David J. (author)
Kuivaniemi, Helena (author)
Lindholt, Jes S. (author)
Jones, Gregory T. (author)
Kong, Augustine (author)
Blankensteijn, Jan D. (author)
Matthiasson, Stefan E. (author)
Thorsteinsdottir, Unnur (author)
Stefansson, Kari (author)
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 (creator_code:org_t)
2010-07-11
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:8, s. 71-692
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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art (subject category)
ref (subject category)

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By the author/editor
Gretarsdottir, S ...
Baas, Annette F.
Thorleifsson, Gu ...
Holm, Hilma
den Heijer, Mart ...
de Vries, Jean-P ...
show more...
Kranendonk, Stee ...
Zeebregts, Clark ...
van Sterkenburg, ...
Geelkerken, Robe ...
van Rij, Andre M ...
Williams, Michae ...
Boll, Albert P. ...
Kostic, Jelena P ...
Jonasdottir, Ada ...
Jonasdottir, Asl ...
Walters, G. Brag ...
Masson, Gisli
Sulem, Patrick
Saemundsdottir, ...
Mouy, Magali
Magnusson, Krist ...
Tromp, Gerard
Elmore, James R.
Sakalihasan, Nat ...
Limet, Raymond
Defraigne, Jean- ...
Ferrell, Robert ...
Ronkainen, Antti
Ruigrok, Ynte M.
Wijmenga, Cisca
Grobbee, Diederi ...
Shah, Svati H.
Granger, Christo ...
Quyyumi, Arshed ...
Vaccarino, Viola
Patel, Riyaz S.
Zafari, A. Mazia ...
Levey, Allan I.
Austin, Harland
Girelli, Domenic ...
Pignatti, Pier F ...
Olivieri, Olivie ...
Martinelli, Nico ...
Malerba, Giovann ...
Trabetti, Elisab ...
Becker, Lewis C.
Becker, Diane M.
Reilly, Muredach ...
Rader, Daniel J.
Mueller, Thomas
Dieplinger, Benj ...
Haltmayer, Meinh ...
Urbonavicius, Si ...
Lindblad, Bengt
Gottsäter, Ander ...
Gaetani, Eleonor ...
Pola, Roberto
Wells, Philip
Rodger, Marc
Forgie, Melissa
Langlois, Nicole
Corral, Javier
Vicente, Vicente
Fontcuberta, Jor ...
Espana, Francisc ...
Grarup, Niels
Jorgensen, Torbe ...
Witte, Daniel R.
Hansen, Torben
Pedersen, Oluf
Aben, Katja K.
de Graaf, Jacque ...
Holewijn, Suzann ...
Folkersen, Lasse
Franco-Cereceda, ...
Eriksson, Per
Collier, David A ...
Stefansson, Hrei ...
Steinthorsdottir ...
Rafnar, Thorunn
Valdimarsson, Ei ...
Magnadottir, Hul ...
Sveinbjornsdotti ...
Olafsson, Isleif ...
Magnusson, Magnu ...
Palmason, Robert
Haraldsdottir, V ...
Andersen, Karl
Onundarson, Pall ...
Thorgeirsson, Gu ...
Kiemeney, Lamber ...
Powell, Janet T.
Carey, David J.
Kuivaniemi, Hele ...
Lindholt, Jes S.
Jones, Gregory T ...
Kong, Augustine
Blankensteijn, J ...
Matthiasson, Ste ...
Thorsteinsdottir ...
Stefansson, Kari
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
Articles in the publication
Nature Genetics
By the university
Lund University
Karolinska Institutet

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