| 1. |
- Johansson Wensman, Jonas, et al.
(författare)
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Kennelhosta
- 2014
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Ingår i: Ulvehunden. - 2246-509X. ; 38, s. 10-11
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 2. |
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| 3. |
- Johansson Wensman, Jonas, et al.
(författare)
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Markers of Borna disease virus infection in cats with staggering disease
- 2012
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Ingår i: Journal of Feline Medicine and Surgery. - 1098-612X .- 1532-2750. ; 14, s. 573-582
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Tidskriftsartikel (refereegranskat)abstract
- Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease. Presently, staggering disease is a tentative clinical diagnosis, only confirmed at necropsy. In this study, cats with staggering disease were investigated to study markers of BDV infection aiming for improvement of current diagnostics. Nineteen cats fulfilled the inclusion criteria based on neurological signs and pathological findings. In 17/19 cats, BDV infection markers (BDV-specific antibodies and/or BDV-RNA) were found, and antibodies in serum (13/16, 81%) were the most common marker. BDV-RNA was found in 11/19 cats (58%). In a reference population without neurological signs, 4/25 cats were seropositive (16%). The clinical history and neurological signs in combination with presence of BDV infection markers, where serology and rRT-PCR on blood can be helpful tools, improve the diagnostic accuracy in the living cat.
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| 4. |
- Johansson Wensman, Jonas, et al.
(författare)
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Borna disease virus infection in cats
- 2014
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Ingår i: Veterinary Journal. - : Elsevier BV. - 1090-0233 .- 1532-2971. ; 201, s. 142-149
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Forskningsöversikt (refereegranskat)abstract
- Bornaviruses are known to cause neurological disorders in a number of animal species. Avian Bornavirus (ABV) causes proventricular dilatation disease (PDD) in birds and Borna disease virus (BDV) causes Borna disease in horses and sheep. BDV also causes staggering disease in cats, characterised by ataxia, behavioural changes and loss of postural reactions. BDV-infection markers in cats have been reported throughout the world. This review summarizes the current knowledge of Borna disease viruses in cats, including etiological agent, clinical signs, pathogenesis, epidemiology and diagnostics, with comparisons to Bornavirus infections in other species.
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| 5. |
- Johansson Wensman, Jonas
(författare)
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Bornaviruses
- 2013
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Ingår i: Mononegaviruses of Veterinary Importance Vol. I: Pathobiology and Molecular Diagnosis. - UK : CABI. - 9781780641799 ; , s. 1-14
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Johansson Wensman, Jonas, et al.
(författare)
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The X proteins of bornaviruses interfere with type I interferon signalling
- 2013
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Ingår i: Journal of General Virology. - : Microbiology Society. - 0022-1317 .- 1465-2099. ; 94, s. 263-269
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Tidskriftsartikel (refereegranskat)abstract
- Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.
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| 7. |
- Blomström, Anne-Lie, et al.
(författare)
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Serological markers of Bornavirus infection found in horses in Iceland
- 2013
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Ingår i: Acta Veterinaria Scandinavica. - : Springer Science and Business Media LLC. - 0044-605X .- 1751-0147. ; 55
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Tidskriftsartikel (refereegranskat)abstract
- Conclusions: This report contains the first evidence of antibodies to Borna disease virus in Iceland. Whether Borna disease virus was the cause of the neurological signs could however not be confirmed by pathology or molecular detection of the virus. As Iceland has very restricted legislation regarding animal imports, the questions of how this virus has entered the country and to what extent markers of Bornavirus infection can be found in humans and animals in Iceland remain to be answered.
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| 8. |
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| 9. |
- Johansson Wensman, Jonas
(författare)
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Bornaviruses
- 2016
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Ingår i: Mononegavirales of Veterinary Importance. Volume II: Molecular Epidemiology and Control. - 9781780644172 ; , s. 1-14
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Bornaviruses are mainly neurotropic viruses causing neurological disease in a wide range of animal species as well as humans. Historically, these viruses have been considered genetically highly conserved, which is unusual for RNA viruses. Introduction of novel methodology, such as microarray and metagenomic tools, has led to the discovery of more diverse bornaviruses, and several virus species are now included in the family Bornaviridae. With novel methodology, endogenous bornavirus-like elements have also surprisingly been detected in the human and other mammalian genomes, some even resulting in protein expression. Mammalian bornaviruses cause Borna disease in horses and sheep, staggering disease in cats and neurological diseases in other species, such as dog, lynx and cattle. It has also been proposed to be linked to neuropsychiatric illnesses in human. Psittaciform and passeriform bornaviruses induce proventricular dilatation disease in psittacine (e.g. parrots and cockatoos) and passerine (e.g. canaries) birds, respectively. Aquatic bird bornaviruses infect waterfowl, such as swans, geese and ducks, mainly asymptomatically. A variegated squirrel bornavirus has been detected in a few human cases of fatal encephalitis, all related to contact with variegated squirrels, in which the same virus was detected. In this chapter, the epidemiology, molecular epidemiology, transmission routes, reservoirs, vectors, zoonotic aspects, treatment and control of bornaviruses are comprehensively described and discussed.
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| 10. |
- Johansson Wensman, Jonas, et al.
(författare)
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Bornaviruses in naturally infected Psittacus erithacus in Portugal: insights of molecular epidemiology and ecology
- 2019
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Ingår i: Infection Ecology & Epidemiology. - : Informa UK Limited. - 2000-8686. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Background: The genus Orthobornavirus comprises non-segmented, negative-stranded RNA viruses able to infect humans, mammals, reptiles and various birds. Parrot bornavirus 1 to 8(PaBV-1 to 8) causes neurological and/or gastrointestinal syndromes and death on psittacines. We aimed to identify and to produce epidemiologic knowledge about the etiologic agent associated with a death of two female Psittacus erithacus(grey parrot). Methods and Results: Both parrots were submitted for a complete standardised necropsy. Tissue samples were analysed by PCR. The findings in necropsy were compatible with bornavirus infection. Analysis revealed PaBV-4 related with genotypes detected in captive and in wild birds. The N and X proteins of PaBV-4 were more related to avian bornaviruses, while phosphoprotein was more related to variegated squirrel bornavirus 1 (VSBV-1). Within the P gene/phosphoprotein a highly conserved region between and within bornavirus species was found. Conclusions: Portugal is on the routes of the intensive world trade of psittacines. Broad screening studies are required to help understanding the role of wild birds in the emergence and spread of pathogenic bornaviruses. PaBV-4 phosphoprotein is closer to VSBV-1 associated with lethalencephalitis in humans than with some of the avian bornaviruses. The highly conserved P gene/phosphoprotein region is a good target for molecular diagnostics screenings.
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