| 1. |
- Thörne, Johan, et al.
(författare)
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Effect of ticlopidine and prostaglandin E on endotoxin-induced pulmonary platelet sequestration in vivo
- 1986
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Ingår i: Circulatory Shock. - 0092-6213. ; 20:1, s. 61-69
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Tidskriftsartikel (refereegranskat)abstract
- Prostaglandin E1 has earlier been shown to decrease pulmonary platelet trapping (PPT) following shock. This experiment was performed to evaluate a new method to study PPT in vivo, and to study the effect of prostaglandin E1 and a new antiplatelet drug (ticlopidine) on PPT in rabbits after i.v. administration of endotoxin. Following platelet labeling with In-111, the rabbits were placed under a scintillation camera for continuous measuring of the activity distribution for 40 minutes. The first five minutes represented reference values, whereafter endotoxin E. coli was injected i.v. The following 2-4 minutes showed a sudden increase of radioactivity over the lungs and a simultaneous decrease over the heart, indicating PPT in the nontreated animals, followed by a slow decrease to almost preshock values during the following 30 minutes. Animals receiving prostaglandin E1 showed a significantly lower activity peak in the lungs after the administration of endotoxin, while the corresponding peak in ticlopidine-treated animals did not differ from that seen in the nontreated animals. In all groups, endotoxin caused a decrease in platelet count, but it was significantly lower in the PGE1-treated animals. The results have shown that this diagnostic model for PPT is reliable and may be used for evaluation of the effect on platelet aggregation in vivo of different drugs
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| 2. |
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| 3. |
- Johansson, K. E., et al.
(författare)
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Oesophagitis, signs of reflux, and gastric acid secretion in patients with symptoms of gastro-oesophageal reflux disease
- 1986
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Ingår i: Scandinavian Journal of Gastroenterology. - Oslo : Informa Healthcare. - 0036-5521 .- 1502-7708. ; 21:7, s. 837-847
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Tidskriftsartikel (refereegranskat)abstract
- In a study comprising 100 patients referred to a surgical clinic with symptoms suggestive of gastro-oesophageal reflux disease the value of different diagnostic procedures was investigated. Positive acid perfusion and 24-h pH tests were the commonest findings. Forty-nine per cent showed a normal oesophageal mucosa or diffuse oesophagitis at endoscopy. The severity of heartburn and regurgitation did not differ between patients with normal oesophageal mucosa and oesophagitis of various severities. The severity of macroscopic oesophagitis was significantly correlated to the total reflux time, the presence of reflux or a hiatal hernia at radiology, an open cardia or reflux at endoscopy, pressure transmission or reflux and low lower oesophageal sphincter pressure at manometry. Gastric hypersecretion was found in 66% of the patients. Gastric acid secretion was not correlated to the severity of oesophagitis or to the findings at 24-h pH test. In patients with severe oesophagitis the sensitivity for radiologic, manometric, and endoscopic signs of incompetence of the gastro-oesophageal junction was 94%.
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| 4. |
- Dahlin, L B, et al.
(författare)
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Mechanical effects of compression of peripheral nerves
- 1986
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Ingår i: Journal of Biomechanical Engineering. - 0148-0731. ; 108:2, s. 2-120
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Tidskriftsartikel (refereegranskat)abstract
- Effects of graded compression on nerve function were analyzed in order to evaluate the relative importance of pressure level and duration of compression for functional deterioration. The pressure was applied by means of a small inflatable cuff. The effects of two pressure levels, i.e., 80 mm Hg applied for 2 hr or 400 mm Hg applied for 15 min, were studied in rabbit tibial nerves. The lower pressure tested, which is known to induce ischemia of the compressed nerve segment, also causes some degree of mechanical deformation of the nerve trunk, which leads to incomplete recovery following pressure release. The duration of compression is of importance for the degree of nerve injury even at the higher pressure level tested.
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| 5. |
- Frisén, Lars, 1939, et al.
(författare)
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Posttraumatic seesaw nystagmus abolished by ethanol ingestion.
- 1986
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Ingår i: Neurology. - 0028-3878. ; 36:6, s. 841-4
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Tidskriftsartikel (refereegranskat)abstract
- We describe a patient who was left with a midchiasmal injury and bitemporal hemianopia after head trauma. Four months later, she developed typical seesaw nystagmus and moderate hydrocephalus. Lumbar punctures did not affect the nystagmus, but a temporary cessation was documented after ingestion of ethanol.
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| 6. |
- Frisén, Lars, 1939
(författare)
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Vanishing optotypes. New type of acuity test letters.
- 1986
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Ingår i: Archives of ophthalmology (Chicago, Ill. : 1960). - 0003-9950. ; 104:8, s. 1194-8
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Tidskriftsartikel (refereegranskat)abstract
- Acuity test letters generated on a television monitor were studied with regard to detection and resolution thresholds, both for the native configurations and after high-pass spatial frequency filtering. Comparisons were made with printed acuity charts of different contrast. Filtering diminished the interval between detection and resolution thresholds. Under some circumstances, a small (1 dB, about 26%) increment in size could make a previously invisible optotype clearly visible, or vice versa. The term vanishing optotype is suggested for acuity targets with this peculiar property. Vanishing optotypes do not seem useful for routine clinical acuity testing, but they may be advantageous, for example, in preferential looking-acuity tests for infants and visual field examinations. Like the present tests, such novel applications can be generated relatively easily on personal computers.
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| 7. |
- Kjällman, L, et al.
(författare)
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The cerebral ocular pursuit pathways. A clinicoradiological study of small-field optokinetic nystagmus.
- 1986
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Ingår i: Journal of clinical neuro-ophthalmology. - 0272-846X. ; 6:4, s. 209-17
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Tidskriftsartikel (refereegranskat)abstract
- Optokinetic nystagmus was tested in patients with intracerebral tumors restricted to one hemisphere, by using a simple, hand-held drum and visual evaluation of symmetry of horizontal response. Computed tomographic mapping revealed that lesions associated with asymmetric optokinetic nystagmus involved the posterior hemisphere. The critical region appeared to extend from the posterior splenium and the anteromedial occipital lobe to the posterior internal capsule. It seemed to course below the posterior horn of the ventricular system, then turn anteriorly, and finally medially, above the temporal horn. It is argued that the posterior extremity of this C-shaped region contains the ipsilateral and contralateral visual inputs to a parietal cortex control over ipsilateral smooth eye movements, and that the anterior extremity contains the efferent motor command pathways destined to the brain stem.
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| 8. |
- Jörgensen, Connie, et al.
(författare)
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Ultrasound measurement of the fetal cerebral ventricles: a prospective, consecutive study
- 1986
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Ingår i: Journal of Clinical Ultrasound. - : Wiley. - 0091-2751 .- 1097-0096. ; 14:3, s. 185-190
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Tidskriftsartikel (refereegranskat)abstract
- Real-time ultrasound was used in 654 consecutive pregnancies to obtain standard growth parameters for the fetal brain. Measurement of the width of the lateral ventricle (LVW) and hemisphere and their relationships to menstrual age, biparietal diameter, and birth weight were determined. The growth of the LVW was to a great extent independent of birth weight but dependent on menstrual age. Thirteen fetuses with a single ventricular width measurements exceeding +2 SD from the mean were separately evaluated, and all but one case were found to be normal.
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| 9. |
- Agardh, Elisabet, et al.
(författare)
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Normal eyes in type 1 diabetics stay normal after one year of treatment with continuous subcutaneous insulin pump
- 1986
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Ingår i: Acta Ophthalmologica. - 0001-639X. ; 64:5, s. 530-532
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Tidskriftsartikel (refereegranskat)abstract
- Seven patients with type 1 diabetes mellitus were restored to near normoglycaemia by treatment with continuous subcutaneous insulin infusion pumps (CSII). The patients were examined with ophthalmoscopy, fundus photography and fluorescein angiography before and one year after the start of CSII treatment. In addition, ophthalmoscopy was performed after 6 months of treatment. All 14 eyes were normal prior to the CSII treatment and none had developed any signs of retinopathy after 6 months or 1 year. It is concluded that metabolic control can be near normalized with CSII treatment without any risk for development of diabetic microangiopathy in type 1 diabetics with normal eyes.
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| 10. |
- Bengnér, Urban, et al.
(författare)
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Epidemiology of ankle fracture 1950 and 1980. Increasing incidence in elderly women
- 1986
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Ingår i: Acta Orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470. ; 57:1, s. 35-37
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Tidskriftsartikel (refereegranskat)abstract
- During 1980-82, 739 ankle fractures occurred in Malmo. These were compared with 383 ankle fractures occurring in 1950-52. In men there was an increase in the age-specific incidence up to the age of 60, especially in fractures of the lateral malleolus. In women there was an increase in the age-specific incidence above the age of 50, both in lateral malleolar fractures and, even more pronounced, in bi- and tri- malleolar fractures.
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