| 1. |
- Safai-Kutti, Soodabeh, et al.
(författare)
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In vitro platelet function in infantile autism.
- 1988
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Ingår i: Folia haematologica (Leipzig, Germany : 1928). - 0323-4347. ; 115:6, s. 897-901
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Tidskriftsartikel (refereegranskat)abstract
- It has previously been demonstrated that patients with infantile autism demonstrate impaired in vivo platelet behaviour. Therefore, in 14 children (13 boys and 1 girl) with infantile autism (aged 2-14, mean 6 years) and 12 healthy control boys (aged 6-15, mean 11 years) we studied in vitro platelet reactivity using ADP- and collagen-induced platelet aggregation. In each child a total of 7 different final concentrations of ADP and 4 different concentrations of collagen were employed. At all concentrations of ADP and collagen used the autistic children consistently exhibited diminished platelet aggregability; the differences, however, did not reach statistical significance. Therefore a wider panel of in vitro tests is apparently required and a larger group of patients be studied to help elucidate the functional/metabolic platelet defect met in infantile autism.
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| 2. |
- Wadenvik, Hans, 1955, et al.
(författare)
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Splenic platelet kinetics and platelet production after major reconstructive vascular surgery.
- 1988
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Ingår i: Acta medica Scandinavica. - 0001-6101. ; 223:2, s. 147-52
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Tidskriftsartikel (refereegranskat)abstract
- By using 111In-labelled platelets and dynamic gamma camera scintigraphy, platelet production rate and intrasplenic platelet kinetics were determined in 13 patients at 1 and 4 months after aortic reconstructive vascular surgery with implantation of dacron prostheses. A significant decrease in platelet production rate and venous platelet count was recorded over time after surgery. Irrespective of whether the exchangeable splenic platelet pool was estimated from initial recovery of platelet-bound radioactivity or from compartmental analysis, the size of this pool was significantly lower at the first study; a change in intrasplenic platelet transit time accounted for the observed difference. Platelet mean life-span increased over time after surgery but the difference between the duplicate studies was not statistically significant. It can be concluded that there is a reduction of platelet production rate and venous platelet count over time after major reconstructive vascular surgery. The early postoperative elevation in the platelet count is mainly the result of an increased platelet production and to a lesser degree due to redistribution of platelets between the splenic platelet pool and general circulation.
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| 3. |
- Wadenvik, Hans, 1955, et al.
(författare)
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The spleen and pooling of blood cells.
- 1988
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Ingår i: European journal of haematology. - 0902-4441. ; 41:1, s. 1-5
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Tidskriftsartikel (refereegranskat)
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