| 1. |
- Pärsson, H, et al.
(author)
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Experimental evaluation of small diameter synthetic arterial grafts
- 1988
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In: International Angiology. - 1827-1839. ; 7:1, s. 60-64
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Journal article (peer-reviewed)abstract
- Platelets labelled with Indium-111 were used to examine the in vivo thrombogenicity of different vascular grafts. The deposition of platelets in two partly different kinds of umbilical vein grafts, double velour Dacron grafts and double velour Dacron grafts with internal collagen was studied as a function of time. The grafts were inserted end to side in the femoral artery of pigs and then imaged for 120 minutes. Platelet distribution was also studied by in vitro static imaging. No difference was seen between the different umbilical vein grafts. The double velour grafts accumulated more platelets, the platelets mainly located in the midportion of the graft. The collagen-impregnated grafts occluded within 45 minutes
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| 2. |
- Ribbe, Else, et al.
(author)
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Platelet aggregation on peritoneal tube grafts and double velour grafts in the inferior vena cava of the pig
- 1988
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In: British Journal of Surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 75:1, s. 81-85
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Journal article (peer-reviewed)abstract
- In 14 pigs the infrarenal vena cava was replaced with a peritoneal tube graft or a collagen-coated double velour graft. With 111In-labelled platelets dynamic in vivo imaging of platelet aggregation over the graft was carried out using a scintillation camera. After removal, the grafts were examined by autoradiography for an evaluation of the platelet aggregation pattern. Measurements of activity in different regions of the grafts were also performed. The results indicated low activity uptakes both in vivo and in vitro. The dynamic study did not show any uniform increase of activity content 1-3 h postoperatively, in any of the groups. During the period 2-3 h postoperatively no increasing activity accumulation was found. Hemashield Microvel grafts had an uptake of 0.19 per cent of the total activity while the corresponding figure for peritoneal tube grafts was 0.17 per cent. The activity distribution on different parts of the grafts indicated lower accumulation on the Hemashield graft surfaces than in the anastomoses, while the accumulation was higher on the graft surface of peritoneal tube grafts. The autoradiographical findings supported this indication. In conclusion, low platelet aggregation was found with both dynamic in vivo imaging and in vitro activity measurements on both peritoneal tube grafts and collagen-coated double velour grafts.
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| 3. |
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