| 1. |
- Brihmer, Christina, et al.
(författare)
-
Efficacy and safety of azithromycin versus lymecyline in the treatment of genital chlamydial infections in women
- 1996
-
Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 1651-1980 .- 0036-5548. ; 28:5, s. 451-454
-
Tidskriftsartikel (refereegranskat)abstract
- To compare the clinical and microbiological efficacy of azithromycin in curing chlamydial infections in women with that of lymecycline, and with a view of the possibility of minimizing the problem of compliance by means of single-dose administration, 146 women with culture-positive Chlamydia trachomatis infections were randomly assigned to treatment with a 1 g bolus dose of azithromycin or a 10-day course of lymecycline 300 mg twice daily. Clinical and microbiological evaluations were performed and adverse effects monitored at check-ups after 15-35 and 40-65 days. Of the 146 patients enrolled in the study, 120 were evaluable. At the second check-up, C. trachomatis was found to have been eradicated in all patients in both treatment groups. Of the 51 patients who had clinical signs and symptoms of genital infection at enrolment, 96% (22/23) of those in the azithromycin group were considered cured (n = 18) or improved (n = 4), as compared with 100% (28/28) of those considered cured (n = 22) or improved (n = 6) in the lymecycline group. Adverse events related, or possibly related, to treatment were reported by 16 (21.6%) of the lymecycline group, but by only 6 (8.3%) of the azithromycin group. The 2 drugs were comparable with regard to microbiological and clinical efficacy in the treatment of genital chlamydial infection in women. The markedly lower rate of side-effects associated with azithromycin may be a feature conducive to patient compliance.
|
|
| 2. |
- Hellberg, D, et al.
(författare)
-
Sexually transmitted diseases and gynecologic symptoms and signs in women with a history of induced abortion
- 1999
-
Ingår i: Sexually Transmitted Diseases. - 1537-4521. ; 26:4, s. 197-200
-
Tidskriftsartikel (refereegranskat)abstract
- PIP: This study examines the relationship between a history of induced abortion and current or previous sexually transmitted diseases (STDs) and other gynecologic symptoms. Study participants consisted of a cohort of women attending 2 family planning and 1 youth clinic; 192 were admitted with history of induced abortion and 804 women served as controls. A structured interview to obtain data on previous genital infections and gynecologic symptoms was conducted and gynecologic examination was performed. Various types of STDs and gynecologic symptoms were diagnosed including chlamydial infection, gonorrhea, genital herpes, genital warts, cervical human papillomavirus infection, bacterial vaginosis, candidiasis, and bacterial vaginosis. The study found a high frequency of gynecologic symptoms in women with history of induced abortion such as abnormal vaginal discharges, pruritus, genital malodor, deep dyspareunia and urinary symptoms. Moreover, a history of gonorrhea, genital chlamydial infection, genital warts, and genital herpes were 1.5-5 times more common among women who experienced induced abortion. As a consequence of the 3-fold increase in the history of STDs, the study found a 4-fold increase of a history of pelvic inflammatory disease in women with induced abortion history. Considering these findings, women attending clinics for induced abortions could be a good target population for STD information programs and campaigns.
|
|
| 3. |
|
|
| 4. |
- Kurova, T, et al.
(författare)
-
Prostitution in Riga, Latvia--a socio-medical matter of concern
- 1998
-
Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 1600-0412 .- 0001-6349. ; 77:1, s. 83-86
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To study the background and the working and socio-economic conditions, and the prevalence of some sexually transmitted diseases (STDs), among street and sex club female Latvian prostitutes. STUDY DESIGN: Structured in-depth interviews, as well as clinical examination and laboratory tests for gonorrhea, syphilis, bacterial vaginosis, trichomoniasis, ectoparasites and HIV-infections. RESULTS: Approximately half of the 107 women stemmed from rural Latvian villages, the rest from the capital city of Riga. Of the women, 15-43 years, 36% were ethnic Latvians and 56% ethnic Russians, as compared to 58% vs. 32% of the population of Latvia. Poor economy with unemployment and miserly living conditions were the main reasons for recruitment to prostitution. The income per client was in the range of 25-30 USD (10-15 Ls), but the pimp and brothel/sex club owner often requires half of the women's fees. Unprotected intercourse was common. Twenty of the women were found to be pregnant. One tenth used narcotic drugs, e.g. ecstasy. The prevalences of gonorrhea, active syphilis, bacterial vaginosis, trichomoniasis and ectoparasites were 10.2%, 15.7%, 68.2%, 35.5% and 15.9% respectively. None was HIV-infected. CONCLUSIONS: There is an urgent need for regulation of the Latvian 'sex industry', means for providing prostitutes with adequate contraceptives, and to allocate resources to clinics for investigation, therapy and counseling.
|
|
| 5. |
|
|
| 6. |
- Mårdh, Per-Anders, et al.
(författare)
-
Are oral contraceptives masking symptoms of chlamydial cervicitis and pelvic inflammatory disease?
- 1998
-
Ingår i: European Journal of Contraception & Reproductive Health Care. - 1362-5187. ; 3:1, s. 41-43
-
Tidskriftsartikel (refereegranskat)abstract
- Tubal factor infertility is often diagnosed without any documented history of pelvic inflammatory disease. Chlamydial infection is one of the most common causes of pelvic inflammatory disease and likely also of infertility and ectopic pregnancy. Oral contraceptives may alter the course of chlamydial infections which may mask the clinical expression of the disease. This paper considers a number of unresolved matters related to oral contraceptive use and its possible influence on the epidemiology and course of chlamydial pelvic inflammatory disease.
|
|
| 7. |
- Mårdh, Per-Anders
(författare)
-
Improvement of surveillance programs for sexually transmitted infections and related conditions
- 1998
-
Ingår i: European Journal of Contraception & Reproductive Health Care. - 1362-5187. ; 3:3, s. 136-146
-
Tidskriftsartikel (refereegranskat)abstract
- The present communication considers possibilities of how to improve surveillance programs for sexually transmitted infections and some conditions not yet included among the 'established' sexually transmitted infections. An extended list of sexually transmitted infection agents is proposed for monitoring and a syndrome-based surveillance program for what and when to screen pregnant women is discussed. Problems of how to deal with recurrences in chronic sexually transmitted infections are discussed. The value of concomitant surveillance programs, for clinicians and laboratories, is stressed. The importance of reporting the method(s) used to establish the diagnosis, as well as the circumstances under which the sampling was made, for example at screening, is also highlighted.
|
|
| 8. |
|
|
| 9. |
- Rodrigues, A G, et al.
(författare)
-
Germ tube formation changes surface hydrophobicity of Candida cells
- 1999
-
Ingår i: Infectious Diseases in Obstetrics and Gynecology. - 1064-7449. ; 7:5, s. 222-226
-
Tidskriftsartikel (refereegranskat)abstract
- Hydrophobic interaction is generally considered to play an important role in the adherence of microorganisms to eukaryotic cells and also to certain inert surfaces. Using a microbe adhesion assay to hydrocarbons (n-hexadecane), 68 strains of Candida albicans and 30 non-albicans strains were studied. Influence of source of isolate, age of the culture, and percentage of germ tube formation on adhesion were studied. C. albicans blastoconidia were found to be hydrophilic; conversely, blastoconidia of non-albicans strains were slightly more hydrophobic. Germ tube formation was associated with a significant rise in cell surface hydrophobicity.
|
|
| 10. |
- Rodrigues, A G, et al.
(författare)
-
Is the lack of concurrence of bacterial vaginosis and vaginal candidosis explained by the presence of bacterial amines?
- 1999
-
Ingår i: American Journal of Obstetrics and Gynecology. - 1097-6868. ; 181:2, s. 367-370
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE AND STUDY DESIGN: We report for the first time an inhibitory effect on cell division and germ tube formation by Candida albicans and strains of other Candida species by putrescine and cadaverine. RESULTS: Both bacterial amines showed a dose-dependent inhibition of germ tube formation by C albicans, as well as budding (inhibition of cell division) of strains of other Candida species (ie, C glabrata, C krusei, and C tropicalis). CONCLUSIONS: We hypothesize that the presence of these and possibly other bacterial amines produced by anaerobes in the vaginal flora and seen in bacterial vaginosis, as in the healthy gut, may explain why candidosis is rarely seen in these instances.
|
|
