| 1. |
- Wallengren, Joanna, et al.
(författare)
-
Capsaicin enhances allergic contact dermatitis in guinea pig.
- 1991
-
Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 24:1, s. 30-34
-
Tidskriftsartikel (refereegranskat)abstract
- Guinea pigs were sensitized to dinitrochlorobenzene (DNCB) by the intracutaneous route and challenged epicutaneously tin the flanks. The intensity of the allergic contact dermatitis was evaluated by inspection and palpation as well us by wet weight determination. With the purpose of diminishing tissue neuropeptides, and substance P in particular, the animals were treated with capsaicin either between induction and challenge, or before sensitization, In comparison with controls, the contact dermatitis was Enhanced in both groups of animals treated with capsaicin.
|
|
| 2. |
- Wallengren, Joanna
(författare)
-
Substance P antagonist inhibits immediate and delayed type cutaneous hypersensitivity reactions.
- 1991
-
Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 1365-2133 .- 0007-0963. ; 124:4, s. 324-328
-
Tidskriftsartikel (refereegranskat)abstract
- The role of substance P (SP) in allergic reactions of the skin was investigated. Spantide, a competitive inhibitor of SP, was injected intracutaneously into the volar aspect of the forearm prior to the following challenges: benzalkonium chloride (irritant delayed reaction), tuberculin (immunological delayed reaction), UVB irradiation, benzoic acid (non-immunological contact urticaria), different food allergens and latex (in patients with immunological contact urticaria). Only the immunological reactions of contact urticaria and the reaction to tuberculin were suppressed by the SP antagonist, indicating that SP is involved in their pathogenesis.
|
|
| 3. |
|
|
| 4. |
|
|
