| 1. |
- Gannedahl, Per E., et al.
(författare)
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Minimal influence of anaesthesia and abdominal surgery on computerized vectorcardiography recordings
- 1995
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Ingår i: Acta Anaesthesiologica Scandinavica. - : Elsevier. - 0001-5172 .- 1399-6576. ; 39:1, s. 71-78
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Tidskriftsartikel (refereegranskat)abstract
- Myocardial infarction still represents a major cause of morbidity and mortality following surgical procedures. Continuous computerized on‐line vector‐ECG has previously been shown to be useful in the detection of myocardial ischaemia, in acute myocardial infarction and unstable angina pectoris and for ischaemia monitoring after PTCA procedures. This method was presently tested for the possible influence of anaesthesia and surgery during cholecystectomy under general anaesthesia (n = 9), and during inguinal hernia repairs using a spinal block (n = 5). The patients had no history, symptoms or signs of ischaemic heart disease. Analyses of vectorcardiographic changes were made in relation to predefined standardized anaesthetic and surgical procedures, all of which potentially could influence the vector‐ECG. Three vectorcardiographic trend parameters were studied: QRS‐vector difference, ST‐vector magnitude and ST‐change vector magnitude. The overall vectorcardiographic changes were minimal and smaller than vectorcardiographic changes previously reported during myocardial ischaemia and infarction. Since anaesthetic and surgical procedures per se had only minor effects on the vector ECG recordings, it is concluded that continuous computerized on‐line vectorcardiography will not be skewed by these procedures. Hence, vectorcardiography has the potential of becoming a new monitor for the detection of perioperative myocardial ischaemia.
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| 2. |
- Jahnson, S., et al.
(författare)
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p53 and Rb immunostaining in locally advanced bladder cancer : relation to prognostic variables and predictive value for the local response to radical radiotherapy
- 1995
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Ingår i: European Urology. - Basel, Switzerland : S. Karger. - 0302-2838 .- 1873-7560. ; 28:2, s. 135-142
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Tidskriftsartikel (refereegranskat)abstract
- The association between known prognostic variables and altered immunostaining for the nuclear proteins retinoblastoma (Rb) and p53 was studied in a homogeneous series of locally advanced bladder cancer. The predictive value of this immunostaining for the local response to intended radical radiotherapy was investigated. Among 262 patients treated with intended radical radiotherapy between 1967 and 1986, a total of 154 patients were evaluable with respect to local response to treatment. The paraffin-embedded specimen from the tumour prior to irradiation was immunostained with the monoclonal antibodies PMG3-245 for Rb and 1801 for p53 nuclear proteins after heating in a microwave oven for 40 min at 650 W. An altered expression of Rb and p53 was observed in 18 and 42% of the tumours, respectively. p53 overexpression was associated with higher tumour grade. However, the results of the p53 and Rb immunostaining procedures had no predictive value for tumor response to radiation treatment, local control or cancer-specific mortality.
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| 3. |
- Karlsson, Mats G., 1960-, et al.
(författare)
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Nasal messenger RNA expression of interleukins 2, 4, and 5 in patients with allergic rhinitis
- 1995
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Ingår i: Diagnostic molecular pathology (Print). - Philadelphia, USA : Lippincott Williams & Wilkins. - 1052-9551 .- 1533-4066. ; 4:2, s. 85-92
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Tidskriftsartikel (refereegranskat)abstract
- In nasal biopsies from 17 adult patients with seasonal allergic rhinitis and from 10 healthy controls, cytokines were analyzed by reverse-transcriptase polymerase chain reaction (RT-PCR). The time-course study during winter included repeated local allergen provocation with subsequent nasal biopsies as well as biopsies taken during pollen season. The RT-PCR for CD44 yielded positive bands in 65 of 71 cases, in which cases mRNA for interleukins 2, 4, and 5 (IL-2, IL-4, and IL-5) were thus investigated by means of seminested PCR. IL-4 mRNA was found almost exclusively in the allergic patients. During provocation a significant increase in IL-4 was noticed compared with controls (p = 0.043). Equally, during the natural pollen season, IL-4 mRNA expression was significantly higher in patients not using nasal corticosteroids compared with those who did (p = 0.011). No differences in IL-2 or IL-5 were observed between the groups. These findings also indicate, together with earlier observations of T-cell activation, a phenotype switch toward T-helper 2 (Th2) cells, and the accumulation (homing) of these T cells in the nasal mucosa, that T cells constitute the main source for IL-4 in the nasal mucosa. Therefore, allergic patients have an increased synthesis of IL-4 when provoked with the allergen, and during natural pollen season this synthesis can be downregulated by corticosteroids. Furthermore, this study exemplifies the versatility of molecular biology in surgical pathology and that even low-copy-number cytokine mRNA can be examined in routinely snap-frozen surgical specimens.
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| 4. |
- Jendle, Johan, 1963-, et al.
(författare)
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Delivery and Retention of an Insulin Aerosol Produced by a New Jet Nebulizer
- 1995
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Ingår i: Journal of Aerosol Medicine. - : Mary Ann Liebert. - 0894-2684 .- 1557-9026. ; 8:3, s. 243-254
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Tidskriftsartikel (refereegranskat)abstract
- UNLABELLED: This study describes the delivery and distribution of an aerosol generated by a jet nebulizer (MAXIN) in an experimental animal model. Anesthetised, intubated and ventilated piglets inhaled radiolabeled technetium diethylene-triamine-penta-acetic acid (99mTc-DTPA) through the endotracheal tube. The lungs were excised en bloc and scintigraphed, using a computerized gamma camera to evaluate the pattern of distribution. By nebulizing radiolabeled 125I-insulin and comparing the activity deposited on inspiratory and expiratory electrostatic filters, delivery and retention of nebulized insulin was assessed. The distribution of aerosol in the lungs was very even and reached the most peripheral parts. The delivery of nebulized insulin was calculated to be 88.9 +/- 5.3% and 36.1 +/- 8.8% of the insulin delivered to the respiratory tract was retained. The immediate local effects of insulin aerosol administration on the lungs were evaluated using light microscopy. No adverse effects were observed at histopathologic examination of the lung tissue.CONCLUSION: This study shows a high penetration of aerosol to the peripheral parts of the lung and efficient delivery of nebulized insulin when using the MAXIN-nebulizer.
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| 5. |
- Ahlman, B., et al.
(författare)
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Elective abdominal surgery alters the free amino acid content of the human intestinal mucosa
- 1995
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Ingår i: European Journal of Surgery. - Stockholm, Sweden : Taylor & Francis. - 1102-4151 .- 1741-9271. ; 161:8, s. 593-601
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To assess the impact of a standard moderately severe surgical operation on the mucosal amino acid content of the duodenum and the colon.Design: Open study.Setting: University hospital, Sweden.Subjects: Nine patients who were to undergo elective open cholecystectomy.Interventions: Endoscopically obtained biopsy specimens from the intestinal mucosa. Main outcome measures: Changes in the content of free amino acids in the duodenum and colon at three days postoperatively.Results: The concentration of glutamine in the duodenum increased by 27% and that of glutamic acid by 34% after operation, whereas their content in colon remained unaltered. The concentration of branched chain amino acids increased by 26% in the duodenal mucosa after operation and by 24% in the colonic mucosa. The total concentration of amino acids (excluding taurine) increased by 9% in the duodenum, but remained unaltered in the colon.Conclusion: This study shows characteristic and consistent alterations in the free amino acid content of the intestinal tract after a moderately severe operation.
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| 6. |
- Bark, Tor, et al.
(författare)
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Glutamine supplementation does not prevent bacterial translocation after non-lethal haemorrhage in rats
- 1995
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Ingår i: European Journal of Surgery. - : Taylor & Francis Scandinavia. - 1102-4151 .- 1741-9271. ; 161:1, s. 3-8
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:To find out whether supplementation of an enteral diet with glutamine would reduce translocation of bacteria to mesenteric lymph nodes or blood after major haemorrhage in rats.DESIGN:Open randomised study.SETTING:University departments of surgery and microbiology, Sweden.MATERIAL:49 Sprague-Dawley rats.INTERVENTIONS:Rats were fed enterally for 7 days on diets supplemented with either glutamine or an isonitrogenous amount of non-essential amino acids. After feeding, 8 experimental and 8 control rats underwent sham operation; 9 and 7, respectively, underwent moderate haemorrhage (to 65 mm Hg); and 9 and 8, respectively, underwent severe haemorrhage (50 mm Hg) without reinfusion.MAIN OUTCOME MEASURES:Microbiological analyses of samples of blood and mesenteric lymph nodes taken 24 hours after haemorrhage.RESULTS:The median (interquartile) number of colony forming units/mesenteric lymph nodes after moderate haemorrhage in animals who were given glutamine supplementation was 11 (0-34) and in control animals 20 (0-178). After severe haemorrhage the corresponding figures were 199 (10-310) and 22 (0-187). No pathogens were isolated from blood cultures.CONCLUSION:Glutamine supplementation before haemorrhage did not reduce bacterial translocation to mesenteric lymph nodes in this rat model.
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| 7. |
- Bejerot, Susanne, et al.
(författare)
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Asperger's syndrome or schizophrenia
- 1995
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Ingår i: Nordic Journal of Psychiatry. - : Taylor & Francis. - 0803-9488 .- 1502-4725. ; 49:2, s. 145-145
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Danielsson-Tham, Marie-Louise, 1947-
(författare)
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Lura rötmånaden!
- 1995
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Ingår i: SLU just nu! – Personaltidning för Sveriges lantbruksuniversitet. - Uppsala : SLU. - 1102-0954. ; :5, s. 20-20
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Tiden mellan den 22 juli och 23 augusti benämns i folkmun rötmånaden. Denna månad är känd för allehanda ruskigheter. Då föds kalvar med två huvuden, såren vill inte läka och mjölken surnar.
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| 9. |
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| 10. |
- Eckervald, Klara, et al.
(författare)
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Barns verbala repetitioner : Är dessa tecken på incest?
- 1995
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Det har förekommit att ett barns repetitioner av ord eller fraser anförts i samband med anmälningar och misstankar om sexuella övergrepp. Syftet är här att närmare undersöka förekomst av verbala repetitioner hos barn i förskoleåldern. Totalt 138 enskilda fall av verbala repetitioner insamlades från föräldrar (enkät till 215 st) och från daghemspersonal (13 intervjuer plus dagboksmetodik med 5 personal). Enligt resultaten är det framför allt yngre barn som upprepar. Det är inga framträdande könsskillnader, men pojkarnas upprepningstopp ligger åldersmässigt något senare än flickornas. Upprepningarna verkar ha med varierande förhållanden eller orsaker att göra. Uppgiftslämnarnas agerande varierar från fall till fall. Ingen personal har gjort någon anmälan med anledning av upprepningar. Enligt författaren har inget exempel bedömts sammanhänga med sexuella övergrepp.
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