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Träfflista för sökning "hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) ;srt2:(2000-2009);conttype:(popularscientific)"

Search: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) > (2000-2009) > Pop. science, debate, etc.

  • Result 1-10 of 249
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  • Johnell, Olof, et al. (author)
  • Osteoporos
  • 2004
  • In: Kropp och genus i medicinen. - 914403217X ; , s. 219-219
  • Book chapter (pop. science, debate, etc.)
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  • Meidute, Sandra, et al. (author)
  • Palmitate-induced beta-cell dysfunction is associated with excessive NO pro-duction and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms
  • 2008
  • In: PLoS ONE. - : Public Library of Science (PLoS). ; 3:5
  • Journal article (pop. science, debate, etc.)abstract
    • Background: Type 2 diabetes often displays hyperlipidemia. We examined palmitate effects on pancreatic islet function in relation to FFA receptor GPR40, NO generation, insulin release, and the PPARgama agonistic thiazolidinedione, rosiglitazone. Principal findings: Rosiglitazone suppressed acute palmitate-stimulated GPR40-transduced PI hydrolysis in HEK293 cells and insulin release from MIN6c cells and mouse islets. Culturing islets 24 h with palmitate at 5 mmol/l glucose induced beta-cell iNOS expression as revealed by confocal microscopy and in-creased the activities of ncNOS and iNOS associated with suppression of glucose-stimulated insulin response. Rosiglitazone reversed these effects. The expression of iNOS after high-glucose culturing was unaffected by rosiglitazone. Downregulation of GPR40 by antisense treatment abrogated GPR40 expression and suppressed palmitate-induced iNOS activity and insulin release. Conclusion: We conclude that, in addition to mediating acute FFA-stimulated insulin release, GPR40 is an important regulator of iNOS expression and dysfunctional insulin release during long-term exposure to FFA. The adverse effects of palmitate were counteracted by rosiglitazone at GPR40, suggesting that thiazolidinediones are beneficial for beta-cell function in hyperlipidemic type 2 diabetes.
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  • Booth, Shirley, et al. (author)
  • Lärande via nätet - oberoende av tid och plats
  • 2005
  • In: Lärande hela livet : en antologi om lärandets betydelse för utveckling i arbetsliv och samhälle. - 9144044305 ; , s. 203-203
  • Book chapter (pop. science, debate, etc.)
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  • Result 1-10 of 249
Type of publication
journal article (94)
conference paper (67)
book chapter (41)
book (15)
reports (11)
other publication (10)
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editorial collection (3)
editorial proceedings (2)
research review (2)
patent (2)
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review (1)
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Type of content
pop. science, debate, etc.  (249)Undo refine
Author/Editor
List, Thomas (12)
Nilner, Maria (11)
Ekberg, EwaCarin (10)
Bondemark, Lars (8)
Lindh, Christina (8)
Edvardsson, Bo, 1944 ... (6)
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Petersson, Arne (6)
Svensson, Peter (4)
Nordmark, Eva (4)
Hägglund, Gunnar (4)
Tegelberg, Åke (3)
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Lohmander, Stefan (3)
Johansson, Eva E (3)
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Akner, Gunnar, 1953- (3)
Lindh, Liselott (3)
Lindgren, Stefan (3)
Hovelius, Birgitta (3)
Lauge-Pedersen, Henr ... (3)
Westbom, Lena (3)
Arner, Marianne (3)
Neilands, Jessica (3)
Lindmark, Ulrika (3)
Davies, J (2)
Dawson, A (2)
Rosén, Ingmar (2)
Lundberg, Johan (2)
Edvardsson, David (2)
Abul-Kasim, Kasim (2)
Sundgren, Pia (2)
Maly, Pavel (2)
Nilsson, H (2)
Wagner, Philippe (2)
Cardemil, Carina (2)
Svensson, P (2)
Norrving, Bo (2)
Nyberg, Gudrun (2)
Eklund, Mona (2)
Nevéus, Tryggve (2)
Ransjö, Maria (2)
Erlanson-Albertsson, ... (2)
Cervenka, Simon (2)
Nilsson, Håkan (2)
Tysk, Curt (2)
Halfvarson, Jonas (2)
Wårdh, Inger (2)
Hugoson, Anders (2)
Anderzen-Carlsson, A ... (2)
Bejerholm, Ulrika (2)
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University
Malmö University (75)
Lund University (70)
Uppsala University (30)
Umeå University (25)
Örebro University (22)
Jönköping University (6)
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Mid Sweden University (5)
Linköping University (4)
Karlstad University (4)
Mälardalen University (3)
University of Gothenburg (2)
Kristianstad University College (2)
Halmstad University (2)
Stockholm University (2)
University West (2)
The Swedish School of Sport and Health Sciences (2)
Karolinska Institutet (2)
Royal Institute of Technology (1)
Linnaeus University (1)
Marie Cederschiöld högskola (1)
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Language
Swedish (150)
English (99)
Research subject (UKÄ/SCB)
Medical and Health Sciences (249)
Social Sciences (12)
Humanities (3)

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