| 1. |
- Bini, G, et al.
(author)
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Regional similarities and differences in thermoregulatory vaso- and sudomotor tone.
- 1980
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In: Journal of Physiology. - : Wiley. - 0022-3751 .- 1469-7793. ; 306, s. 553-65
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Journal article (peer-reviewed)abstract
- 1. Skin nerve sympathetic activity was recorded simultaneously from the following pairs of nerves: left and right median, median and peroneal, left and right peroneal, posterior cutaneous antebrachial and superficial radial, posterior cutaneous antebrachial and median. The recordings were performed on healthy subjects exposed to different ambient temperatures. Electrodermal responses and pulse plethysmograms were recorded from the neural innervation zones. 2. Vasoconstriction impulse bursts recorded simultaneously from the median and peroneal nerves during exposure to a cold environment showed a striking similarity with respect to the timing and strength of individual bursts. A similar strong correlation was observed also among sudomotor bursts recorded simultaneously from the posterior cutaneous antebrachial and superficial radial nerve during exposure to a warm environment. 3. On some occasions, such as during exposure to a moderately warm environment or emotional stress, a temporal correlation was also observed between vasoconstrictor bursts recorded from the median and sudomotor bursts recorded simultaneously from the posterior cutaneous antebrachial nerve. 4. The double nerve recordings provided evidence that in the distal glabrous skin areas reflex thermoregulatory functions are mainly executed via vasoconstrictor fibres whereas sudomotor fibres are brought into action only at relatively high temperature. On the contrary, in the hairy skin on the dorsal side of forearm and hand reflex thermoregulation is to a large extent executed via sudomotor fibres.
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| 2. |
- Bini, G, et al.
(author)
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Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves.
- 1980
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In: Journal of Physiology. - : Wiley. - 0022-3751 .- 1469-7793. ; 306, s. 537-52
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Journal article (peer-reviewed)abstract
- 1. Recordings of multiunit sympathetic activity were made from human nerve fascicles supplying hairy and glabrous skin of the extremities in healthy subjects exposed to different ambient temperatures. Sudomotor and vasomotor events accompanying the neural activity were monitored by simultaneous recordings of electrodermal and pulse plethysmographic events (Pleth) in the neural innervation zones. 2. By exposing the subject to warm (43 degrees C) or cold (15 degrees C) environments, it was possible to obtain a selective activation of either the sudomotor or the vasoconstrictor neural system, respectively, with suppression of spontaneous activity in the other system. 3. Bursts of both vasoconstrictor and sudomotor nerve activity were found to occur at certain preferred intervals which were integer multiples of a period of about 0 . 6 sec (100 cycles/min). With high sudomotor or vasoconstrictor tone the 100 cycles/min rhythm was prominent but with decreasing tone slower subharmonic rhythms prevailed. Respiratory rhythms were also discerned as well as slower rhythms attributable to oscillatory tendencies in thermoregulatory servos. 4. Vasoconstrictor bursts had longer mean duration than sudomotor bursts, a finding attributed to a slower conduction velocity of vasoconstrictor as compared to sudomotor impulses. 5. With increasing incidence of bursts transient electrodermal or plethysmographic responses following individual bursts merged, and thus the fast neural rhythms were not discernible in either the electrodermal or Pleth traces. Given increments in firing rate of nerves produced less additional vasoconstriction at high than at low firing rates. The rhythm generating mechanisms may help to restrict rates of individual fibres to the low range which provides high gain in the neuroeffector transfer functions.
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| 3. |
- May, F E, et al.
(author)
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Mouse mammary tumour virus related sequences are present in human DNA.
- 1983
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In: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 11:12, s. 4127-39
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Journal article (peer-reviewed)abstract
- MuMTV-related sequences have been identified in the DNA of human breast cancer cells using the Southern transfer technique and hybridisation with cloned MuMTV DNA under conditions in which partially mismatched sequences form stable hybrids. Hybridisation with cloned fragments of the MuMTV genome showed that the gag-pol region shares the most homology (estimated to be greater than 80%) with the human MuMTV-related sequences, however, DNA fragments partially homologous to the MuMTV LTR, gag ad env regions were also detected. Analysis of several human DNA samples suggests that the majority of the human MuMTV-related sequences are genetically transmitted but additional Eco R1 fragments were detected in the DNA of one out of three breast cancer cell lines, MCF7. These sequences are potential probes for the human MuMTV-related retroviral sequences and will allow their possible role in human breast cancer to be evaluated.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Bowald, S, et al.
(author)
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Pulmonary microembolism during and after aortic cross-clamping in heparinized and non-heparinized pigs.
- 1980
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In: Acta chirurgica Scandinavica. - 0001-5482. ; 146:5, s. 351-6
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Journal article (peer-reviewed)abstract
- The occurrence of pulmonary microembolism after aortic clamping and declamping was investigated in 21 young pigs. The prophylactive effect of heparin was also examined. Eight animals were heparinized, while 13 did not receive heparin. In 15 pigs the plasma concentration of fibrinogen was determined before, during and after clamping of the aorta. External detection of 51Cr-labelled platelets and 125I-labelled fibrinogen was performed. Lung tissue from these animals was homogenized and analysed for radioactivity. Specimens were taken from the lungs of all animals for morphological investigation. A significant decrease in plasma fibrinogen concentration was noted during the aortic clamping in non-heparinized animals. Morphological studies of lung tissue revealed numerous fibrin/platelet thrombi, leukocyte and platelet aggregates, atelectases and bleedings. In homogenized lung tissue, areas with elevated radioactivity were found, indicating fibrin/platelet entrapment. No such changes were seen in pigs pretreated with heparin. It was found that pulmonary microembolism occurs frequently after aortic clamping if heparin is not given at an early stage of the procedure.
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| 8. |
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| 9. |
- Gerdin, Bengt, 1947-, et al.
(author)
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Spontaneous scrotal emphysema--a cause of scrotal swelling.
- 1985
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In: Scandinavian Journal of Urology and Nephrology. - 0036-5599 .- 1651-2065. ; 19:1, s. 77-9
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Journal article (peer-reviewed)abstract
- Scrotal emphysema developed in a 24-year-old man without any sign of infection and without any trauma involved. The condition gradually improved over a few days and at follow-up one week later he was back to his normal state. No clue to the cause was found and it is therefore justifiable to claim that the patient has a 'spontaneous scrotal emphysema'.
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| 10. |
- Karlson, Bo, et al.
(author)
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On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment
- 1986
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In: Acta medica Scandinavica. - : Wiley. - 0001-6101. ; 220:4, s. 347-350
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Journal article (peer-reviewed)abstract
- Thrombotest (TT) values were studied in patients fed an ordinary diet and on continuous and well controlled warfarin therapy because of deep venous thrombosis or pulmonary embolism. The aim was to characterize the effect of single and multiple administrations (daily during one week) of vitamin K1 (Konakion), vitamin K-rich vegetables such as spinach and broccoli, and table wine. Single administration of 250 micrograms vitamin K1, 250 g spinach, 250 g broccoli and 37.5 cl wine did not result in TT-values outside the therapeutic range. However, when Konakion, broccoli and spinach were given daily during one week the TT-values tended to rise above the therapeutic limit, requiring dose adjustment. On the basis of this study it appears that excessive intake of vitamin K-rich food and a moderate intake of alcohol on one occasion may be permitted during anticoagulant therapy.
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