| 1. |
- Dahlberg, L., et al.
(författare)
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Authors' reply
- 1995
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967. ; 54:8, s. 685-685
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
- Saxne, Tore, et al.
(författare)
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Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis
- 1995
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Ingår i: Arthritis and Rheumatism. - 1529-0131. ; 38:1, s. 82-90
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Tidskriftsartikel (refereegranskat)abstract
- Objective. Bone sialoprotein (BSP) was quantified in synovial fluids and sera from rheumatoid arthritis (RA) patients to elucidate whether its release from bone relates to the degree of joint tissue destruction. Osteocalcin was assayed for comparison. Methods. BSP and osteocalcin levels were determined by immunoassays of knee synovial fluids and of sera from RA patients who were selected on the basis of radiographic knee joint tissue damage. Results. Synovial fluid concentrations of BSP increased with increasing degrees of knee joint damage (rs = 0.6848, P < 0.001). Synovial fluid concentrations of osteocalcin did not relate to the degree of joint damage. Serum concentrations of BSP were increased, but did not relate to the degree of joint damage. Serum concentrations of osteocalcin were normal, but increased within the range of normal during progression of joint destruction (rs = 0.4567, P < 0.001). Conclusion. Quantification of BSP in synovial fluid holds promise as a useful means of assessing the degree of tissue damage at the molecular level in patients with RA.
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| 4. |
- Saxne, Tore, et al.
(författare)
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Matrix proteins: Potentials as body fluid markers of changes in the metabolism of cartilage and bone in arthritis
- 1995
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Ingår i: Journal of Rheumatology. - 0315-162X. ; 22 (suppl 43), s. 71-74
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Tidskriftsartikel (refereegranskat)abstract
- Altered dynamics of cartilage and bone matrix in joint diseases results in increased release of macromolecules into synovial fluid (SF). Such macromolecules are increasingly explored as potential markers of damage and severity. This report focuses on the possibilities of using quantification of tissue specific markers for grading the tissue lesion at the molecular level in arthritis. The theoretical and experimental rationale for such an approach is supported by the results in clinical studies. These studies indicate that simultaneous analysis of multiple cartilage and bone markers in the same SF or serum sample could be useful for defining degree of tissue involvement in rheumatoid arthritis and, possibly, in osteoarthritis.
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