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- Bozorg, Soran Rabin, 1993-
(författare)
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Various Aspects of Gastrointestinal Disease : Examining Validity and Health Economic Outcomes
- 2022
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: Recent years have seen significant research advances within the gastroenterological field. Some of these consist of the recognition of serrated polyps as a precursor to colorectal cancer, and the realization of the health economic burden associated with gastrointestinal diseases.Aim: In this thesis, we aim to validate the specificity of serrated polyps in the ESPRESSO cohort (Paper I). We also aim to estimate work loss in patients with celiac disease, including the temporal relationship of work loss before and after diagnosis (Paper II).Method: By using the ESPRESSO cohort, we collected data on patients with serrated polyps and patients with celiac disease. In Paper I, the specificity of serrated polyps in the ESPRESSO cohort were validated by a structured retrospective review of patient chart. In Paper II, we estimated work loss in patients with celiac disease as compared withgeneral-population comparators matched on age, sex, county of residence and year of diagnosis.Result: The presence of a serrated polyp was confirmed in 101 out of 106 individuals identified through the ESPRESSO cohort, yielding a positive predictive value of 95% (95% confidence interval: 89-98%). Patients with celiac disase had 42.5 lost work days as compared to 28.6 days in comparators (mean difference, 14.7; 95% confidence interval, 13.2-16.2), corresponding to a relative increase of 49%. Excess work loss in patients with celiac disease was observed even 5 years before diagnosis and remained eleveated during the years after diagnosis this loss. Notebly, the excess work loss was concentrated to a small proportion while most celiac patients did not have any work loss before or after diagnosis. Conclusion: The ESPRESSO cohort has a high specificity for serrated polyps. Patients with celiac disease miss more work days than the general population even before diagnosis, and this loss persists after diagnosis.
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- Rådman, Lisa, 1983-
(författare)
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Self-reported symptoms and neurosensory function after electrical accidents : a survey among Swedish male electricians
- 2016
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Professionals working in electrical fields are at risk for accidental exposure to electricity on a daily basis. Electrical accidents can cause long-term sequelae manifesting as neurological symptoms, including in the peripheral nervous system.The overall aim of this licentiate thesis was to describe the occurrence of selfreported and neurosensory symptoms after electrical accidents. Specifically, this thesis aimed to I) describe self-reported symptoms at different points in time; II) assess neurosensory function in relation to previous electrical accidents; III) evaluate the impact of high vs. low voltage as well as that of the no-let-go phenomenon; and IV) gain knowledge about the safety culture among Swedish electricians.A retrospective survey including 523 Swedish male electricians was conducted. Electricians reporting persistent symptoms were invited to a clinical examination that included quantitative sensory testing (QST); 23 electricians participated. The most commonly self-reported symptoms associated with electrical accidents were pain, reduced sensation and reduced muscle function. For a small percentage, these symptoms were persistent. Reduced neurosensory function with regard to thermal perception was determined using QST and functional testing and was particularly evident in the thermal perception tests; roughly half of the group exhibited abnormally reduced clinical warmth and cold perception thresholds and tactile gnosis test values, the latter of which were all below normal except for those of two electricians. The findings also indicate that electricians accidentally exposed to high voltage (HV) frequently report more symptoms than do electricians exposed to low voltage (LV). There were deficiencies in the preventative efforts and reporting routines pertinent to potential electrical accidents. In summary, the main results of this licentiate thesis show that sensory symptoms can be persistent, especially after an HV accident, and that these selfreported symptoms can be manifested as injuries on the small nerve fibres. The results of the present study can provide methods to be used for follow-up testing in clinical practise. Furthermore, there is a need to improve the workplace safety culture for electricians in order to improve the numbers of follow-ups.
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