| 1. |
- Landberg, Göran
(författare)
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Multiparameter analyses of cell cycle regulatory proteins in human breast cancer: a key to definition of separate pathways in tumorigenesis.
- 2002
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Ingår i: Adv Cancer Res. - 0065-230X. - 9780120066841 ; 84, s. 35-56
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Breast cancer is one of the most common cancer forms affecting many women. The disease nevertheless has widely varying behavior and therefore patient outcome, and an important undertaking is to define and understand the molecular mechanisms behind these actions. Defects in the G1/S transition in the cell cycle affect both tumor proliferation and the fidelity of check points responsible for chromosomal integrity and DNA damage response and has lately been shown to represent one of a rather limited set of key aberrations in the transformation process. Many cell cycle regulatory proteins are either oncogenes or suppressor genes or are closely associated to the transformation process. The types of aberrations in the G1/S transition seem to be different in various cancers but are nevertheless often linked to clinical behaviors. In this review the role of multiparameter analyses of cell cycle regulatory proteins in breast cancer will be outlined with special attention to pattern analyses as well as the definition of two contrasting pathways in tumorigenesis defined by either cyclin D1 or cyclin F overexpression.
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| 2. |
- Lindblad, Per, 1953-, et al.
(författare)
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Kidney Cancer
- 2002
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Ingår i: Textbook of Cancer Epidemiology. - New York NY USA : Oxford University Press. - 0195109694
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Thodeti, Charles Kumar, et al.
(författare)
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Leukotriene D4-induced calcium signaling in human intestinal epithelial cells
- 2002
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Ingår i: Eicosanoids and other bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. - Boston, MA : Springer US. - 0065-2598. - 9781461501930 - 9780306472831 ; 507, s. 91-187
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Bokkapitel (refereegranskat)abstract
- LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and downstream of Gi protein, that is essential for LTD4-induced Ca2+ influx. This model of the LTD4-induced Ca2+ signaling pathways in intestinal epithelial cells is outlined schematically in Fig. 1.
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| 4. |
- Öhd, John F, et al.
(författare)
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Do leukotrienes increase cell viability in human intestinal epithelial cells?
- 2002
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Ingår i: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. - Boston, MA : Springer US. - 0065-2598. - 9781461501930 - 9780306472831 ; 507, s. 8-193
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Bokkapitel (refereegranskat)abstract
- In this preliminary report we present data showing that leukotrienes increase the baseline cell viability in human intestinal epithelial cells and that LTB4 partially reverses the morphological hallmarks of non-necrotic cell death induced by the COX-2 specific inhibitor NS-398. The proposed signaling mechanisms regulating these events are summarized in fig. 3. Please view the work on LT signal transduction in these cells by Thodeti et al. in this volume.
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