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Olf/EBF proteins ar...
Olf/EBF proteins are expressed in neuroblastoma cells : potential regulators of the Chromogranin A and SCG10 promoters
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- Persson, Paula (author)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmö, Sweden
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- Manetopoulos, Christina (author)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmö, Sweden
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- Lagergren, Anna (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department for Stem Cell Biology, Lund University, Lund, Sweden
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- Nygren, Jens Martin, 1976- (author)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine,Department for Stem Cell Biology, Lund University, Lund, Sweden
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- Gisler, Ramiro (author)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine,Department for Stem Cell Biology, Lund University, Lund, Sweden
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- Axelson, Håkan (author)
- Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine,Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmö, Sweden
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- Sigvardsson, Mikael (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department for Stem Cell Biology, Lund University, Lund, Sweden
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: International Journal of Cancer. - : Wiley-Liss, Inc.. - 0020-7136 .- 1097-0215. ; 110:1, s. 22-30
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Abstract
Subject headings
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- The childhood malignancy neuroblastoma is derived from developmentally arrested sympathetic nervous system precursor cells. To obtain further insight into the molecular processes involved in the formation of these tumors, we decided to investigate the functional role of Olf/EBF (O/E) transcription factors in human neuroblastoma cells. We here report that O/E-1 and O/E-2 are expressed at variable levels in neuroblastoma cell lines and that O/E proteins could be identified by electrophoretic mobility shift assays. To identify potential neuronal target genes for O/E proteins in neuroblastoma cells we investigated the ability of a set of neuronal promoters to interact with O/E-1 in electrophoretic mobility shift assays. This analysis suggested that the Chromogranin A (CgA) and SCG10 promoters both contained binding sites for O/E-1. O/E-1 was able to activate the CgA promoter in vivo and mutation of the O/E-1 binding site in the CgA promoter reduced the functional activity of the element to about 60% of the wild-type in neuroblastoma cells, supporting the idea that O/E proteins may be involved in the control of the CgA promoter. Furthermore, overexpression of O/E-1 in hippocampal progenitor cells led to neurite outgrowth, indicative of a role for O/E proteins in neuronal differentiation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Chromogranin A
- Differentiation
- EBF
- Neuroblastoma
- Olf
- SCG10
- Sympathetic nervous system
- MEDICINE
- MEDICIN
- TECHNOLOGY
Publication and Content Type
- ref (subject category)
- art (subject category)
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