| 1. |
- Falk Erhag, Hanna, et al.
(författare)
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A Multidisciplinary Approach to Capability in Age and Ageing
- 2022
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- This open access book provides insight on how to interpret capability in ageing – one’s individual ability to perform actions in order to reach goals one has reason to value – from a multidisciplinary approach. With for the first time in history there being more people in the world aged 60 years and over than there are children below the age of 5, the book describes this demographic trends as well as the large global challenges and important societal implications this will have such as a worldwide increase in the number of persons affected with dementia, and in the ratio of retired persons to those still in the labor market. Through contributions from many different research areas, it discussed how capability depends on interactions between the individual (e.g. health, genetics, personality, intellectual capacity), environment (e.g. family, friends, home, work place), and society (e.g. political decisions, ageism, historical period). The final chapter by the editors summarizes the differences and similarities in these contributions. As such this book provides an interesting read for students, teachers and researchers at different levels and from different fields interested in capability and multidisciplinary research.
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| 2. |
- Javeed, Ashir, 1989-, et al.
(författare)
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Predicting Dementia Risk Factors Based on Feature Selection and Neural Networks
- 2023
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Ingår i: Computers, Materials and Continua. - : Tech Science Press. - 1546-2218 .- 1546-2226. ; 75:2, s. 2491-2508
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Tidskriftsartikel (refereegranskat)abstract
- Dementia is a disorder with high societal impact and severe consequences for its patients who suffer from a progressive cognitive decline that leads to increased morbidity, mortality, and disabilities. Since there is a consensus that dementia is a multifactorial disorder, which portrays changes in the brain of the affected individual as early as 15 years before its onset, prediction models that aim at its early detection and risk identification should consider these characteristics. This study aims at presenting a novel method for ten years prediction of dementia using on multifactorial data, which comprised 75 variables. There are two automated diagnostic systems developed that use genetic algorithms for feature selection, while artificial neural network and deep neural network are used for dementia classification. The proposed model based on genetic algorithm and deep neural network had achieved the best accuracy of 93.36%, sensitivity of 93.15%, specificity of 91.59%, MCC of 0.4788, and performed superior to other 11 machine learning techniques which were presented in the past for dementia prediction. The identified best predictors were: age, past smoking habit, history of infarct, depression, hip fracture, single leg standing test with right leg, score in the physical component summary and history of TIA/RIND. The identification of risk factors is imperative in the dementia research as an effort to prevent or delay its onset.
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| 3. |
- Wu, Jing, et al.
(författare)
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Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? : A systematic review and dose-response meta-analysis.
- 2023
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Ingår i: Ageing Research Reviews. - : Elsevier. - 1568-1637 .- 1872-9649. ; 83
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to quantify the relationships between the American Heart Association (AHA) Cardiovascular Health (CVH) metrics, namely AHA Life's Simple 7, and cognitive outcomes. We searched PubMed and Embase (January 1, 2010-August 24, 2022) and finally included 14 longitudinal studies (311654 participants with 8006 incident dementia cases). Random-effects meta-analysis and one-stage linear mixed-effects models were performed. Increased CVH score seemed to associate with decreased risk of incident dementia in a linear manner, but this relationship varied by the measurement age of CVH metrics. That is, midlife CVH tended to have a linear association with late-life dementia risk, whereas a J-shaped association was observed between the late-life CVH score and dementia. In addition, late-life dementia risk was reduced significantly if individuals maintained an ideal level of AHA's CVH guidelines of physical activity, fasting plasma glucose, total cholesterol, and smoking. However, our meta-analysis did not show a significant association between CVH score and global cognitive decline rate. Following AHA's CVH guidelines and maintaining CVH at an optimal level would substantially reduce the late-life dementia risk. More research is required to explore the link between a favorable CVH score and cognitive trajectories among cognitively asymptomatic older populations.
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| 4. |
- Turunen, Merita, et al.
(författare)
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Computer-based cognitive training for older adults : Determinants of adherence
- 2019
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Ingår i: PLOS ONE. - San Fransisco, USA : Public Library Science. - 1932-6203. ; 14:7, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- The possibilities of computer-based cognitive training (CCT) in postponing the onset of dementia are currently unclear, but promising. Our aim is to investigate older adults ' adherence to a long-term CCT program, and which participant characteristics are associated with adherence to the CCT. This study was part of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). Participants were 60-77-year-old individuals with increased dementia risk, recruited from previous population-based studies. The participants included in this study (n = 631) had been randomized to receive a multi-domain lifestyle intervention, including CCT. The measure of adherence was the number of completed CCT sessions (max = 144) as continuous measure. Due to a substantial proportion of participants with 0 sessions, the zero inflated negative binomial regression analyses were used to enable assessment of both predictors of starting the training and predictors of completing a higher number of training sessions. Several cognitive, demographic, lifestyle, and health-related variables were examined as potential predictors of adherence to CCT. Altogether, 63% of the participants participated in the CCT at least once, 20% completed at least half of the training, and 12% completed all sessions. Previous experience with computers, being married or cohabiting, better memory performance, and positive expectations toward the study predicted greater odds for starting CCT. Previous computer use was the only factor associated with a greater number of training sessions completed. Our study shows that there is a large variation in adherence to a long-lasting CCT among older adults with an increased risk of dementia. The results indicate that encouraging computer use, and taking into account the level of cognitive functioning, may help boost adherence to CCT.
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| 5. |
- Pan, Kuan-Yu, et al.
(författare)
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The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia
- 2020
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Ingår i: Aging. - : Impact Journals, LLC. - 1945-4589. ; 12:4, s. 3730-3746
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Tidskriftsartikel (refereegranskat)abstract
- In this population-based prospective study, we examined the association of job demand-control combinations with dementia, and explored the roles of Apolipoprotein E epsilon4 (APOE epsilon 4) and work duration in this association. A total of 2,579 dementia-free individuals aged 60+ years from Sweden were followed over 12 years. Dementia diagnosis was made by physicians. Lifelong occupational experience was collected, and job demands and control were assessed using a psychosocial job-exposure matrix. Data were analyzed using multivariate Cox proportional hazard models. During the follow-up, 282 people developed dementia. Passive jobs (low control/low demands) were related to a higher risk of dementia compared with active jobs (high control/high demands) among the younger-old (aged <= 72 years), but not among the older-old (aged >= 78 years). Among the younger-old, compared to those with no passive job experience, those with 11+ years in passive jobs had a higher dementia risk. The joint-effect analyses showed that APOE epsilon 4 carriers with passive jobs had an even higher risk of dementia compared to APOE epsilon 4 non-carriers with active jobs. These findings suggest that passive jobs are related to a higher dementia risk among the younger-old. APOE epsilon 4 and long work duration may amplify the impact of passive jobs on dementia.
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| 6. |
- Patra, Kalicharan, et al.
(författare)
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Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease
- 2018
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Ingår i: Alzheimer's Research & Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in neurodegenerative diseases such as Alzheimer's disease (AD), prompting validation of KLK6 as a potential biomarker of disease. However, analyses of both plasma and cerebrospinal fluid (CSF) levels of KLK6 in patients with AD have been inconclusive. We present a detailed analysis of KLK6 in plasma and CSF in two separate cohorts in a cross-sectional and a longitudinal clinical setting. Methods: The cross-sectional cohort included control subjects without dementia and patients with AD, and the longitudinal cohort included patients with MCI and patients with AD followed over a 2-year period. Plasma and CSF levels of KLK6 were quantified by use of a previously developed and validated enzyme-linked immunosorbent assay. Statistical analyses were performed to compare KLK6 levels between diagnostic groups and to identify potential associations between KLK6 level, age, apolipoprotein E (APOE) genotype, total apoE level and the classical CSF AD biomarkers. Results: In the cross-sectional setting, KLK6 levels in plasma but not in CSF were significantly higher in the AD group than in control subjects. CSF but not plasma KLK6 levels were positively correlated with age in both the cross-sectional and longitudinal settings. In both cohorts, the CSF KLK6 levels were significantly and positively correlated with the CSF levels of core AD biomarkers. Total plasma and CSF apoE levels were positively associated with KLK6 in the cross-sectional study. Finally, during the 2-year monitoring period of the longitudinal cohort, CSF KLK6 levels increased with disease progression over time in the investigated patient groups. Conclusions: In two separate cohorts we have confirmed the previously reported correlation between age and CSF levels of KLK6. Increased plasma KLK6 levels in patients with AD with a more advanced disease stage suggest KLK6 as a potential biomarker in patients with AD with more severe dementia. Significant correlations between KLK6 levels and core CSF AD biomarkers suggest molecular links between KLK6 and AD-related pathological processes.
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| 7. |
- Lindhe, Andreas, 1981, et al.
(författare)
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Användningen av MACRO-DB i tillståndsärenden och effekter av ny modellversion: Enkätstudie och samhällsekonomisk analys av arbetet med MACRO-DB
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I syfte att skydda dricksvattentäkter, dvs. yt- och grundvattenresurser, kan användningen av växtskyddsmedel regleras genom att exempelvis ställa krav på tillstånd för yrkesmässig användning inom vattenskyddsområden. Att bedöma när, hur och vilka växtskyddsmedel som kan spridas kan vara komplicerat. För att underlätta arbetet med att både ta fram och handlägga tillståndsärenden finns därför modellverktyget MACRO-DB. Verktyget har utvecklats av SLU Centrum för kemiska bekämpningsmedel i miljön (CKB) och används för att simulera bekämpningsmedelsläckage till yt- och grundvatten och bedöma om risken är acceptabelt låg eller inte. År 2018 gjordes en satsning där både Havs- och vattenmyndigheten (HaV) och CKB gjorde investeringar för att vidareutveckla MACRO-DB. Syftet med analysen som presenteras i denna rapport har varit att utvärdera om satsningen varit samhällsekonomiskt motiverad med hjälp av en kostnads-nyttoanalys (KNA). För att ta fram nödvändigt underlag och ge en bild av dagens arbete med tillståndsärenden för yrkesmässig användning av växtskyddsmedel på jordbruksmark inom vattenskyddsområden har en enkätundersökning genomförts. Enkäten skickades till samtliga svenska kommuner och syftade specifikt till att kartlägga användningen av MACRO-DB. Den genomförda enkätstudien besvarades av 58 % av Sveriges kommuner och bedöms baserat på detta och den geografiska spridningen ge en bra bild av dagens arbete med tillståndsärenden för användning av växtskyddsmedel på jordbruksmark inom vattenskyddsområden och specifikt användningen av MACRO-DB. Av de kommuner som besvarat enkäten är det 71 % som handlägger den aktuella typen av ärenden och av dessa är det 61 % som använder MACRO-DB som del av beslutsunderlaget. En majoritet av kommunerna använder såldes MACRO-DB. Bland de som inte använder MACRO-DB beror det framför allt på att man inte känner verktyget. Endast en mindre andel anser att det är inte rimligt att ställa krav på användning av MACRO-DB i den typ av ärenden de hanterar. Av de kommuner som använder MACRO-DB gör 55 % egna körningar för att kontrollera resultaten som lämnas in med tillståndsansökningarna. En stor andel (44 %) gör i stället granskningar av underlagsmaterial och antaganden. Enligt drygt hälften (53 %) av kommunerna tar dricksvattenproducenten del av uppgifter om vilka växtskyddsmedel som används inom vattenskyddsområden, i syfte att anpassa kontrollen av förekomst av växtskyddsmedelsrester i rå- och dricksvatten. Resultaten från enkäten visar också att majoriteten av kommunerna som använder MACRO-DB (93 %) anser att verktyget fungerar bra (61 %) eller mycket bra (32 %) som hjälpmedel. De förslag som lämnats på hur användningen skulle kunna förbättras innefattar bland annat behov av utbildning och annan stöttning men även behovet av mindre tidskrävande simuleringar. Att reducera simuleringstiden har varit ett av syftena med den uppdatering av MACRO-DB som gjorts och är en av de nyttor som ingår i den genomförda KNA:n. I analysen har fokus varit på följande kostnader och nyttor: (i) investeringarna som HaV och CKB gjort, (ii) tidsvinster som den nya modellversionen ger för kommuner, rådgivare och andra aktörer, (iii) möjliga effekter av en ökad livsmedelproduktion om det blir möjligt att söka tillstånd för spridning av växtskyddsmedel på odlingsmark där det idag råder förbud, och (iv) förlust av miljönyttor som en ökad spridning av växtskyddsmedel kan ge upphov till. Utifrån de antaganden som scenarierna i KNA:n bygger på bedöms nyttorna kunna överstiga kostnaderna, vilket alltså indikerar att satsningen på nya MACRO-DB kan vara samhällsekonomiskt motiverad. Skillnaden mellan nyttor och kostnader är samtidigt inte så betydande att ett annat resultat helt kan uteslutas, det vill säga att kostnaderna skulle kunna överstiga nyttorna. Scenarierna bygger på flera antaganden som är osäkra och de presenterade resultaten över samhällsekonomisk lönsamhet bör därför tolkas med viss försiktighet. Det kan dock konstateras att nyttorna till följd av tidsbesparingar är i samma storleksordning som investeringskostnaderna, vilket innebär att satsningen kan vara samhällsekonomiskt även om endast dessa aspekter beaktas. Osäkerheterna bedöms vara störst i de uppskattade nyttorna av ökad livsmedelsproduktion samt de minskade miljönyttorna. Dessa poster i KNA:n beskriver för- respektive nackdelarna som uppstår om det blir möjligt att söka tillstånd för spridning av växtskyddsmedel på odlingsmark där det idag rådet förbud. Resultaten visar att även dessa nyttor och kostnader är i samma storleksordning. Det kan därför konstateras att såväl möjligheten att bruka marken för livsmedelproduktion som skyddet av yt- och grundvattenresurser är förknippade med stora nyttor. Skyddet av yt- och grundvattenresurserna behöver därför säkerställas samtidigt som åtgärderna inte ska vara onödigt långtgående så att de ger orimliga restriktioner i markanvändningen och i detta fall effekter på livsmedelproduktionen. Verktyg och hjälpmedel som MACRO-DB är därför viktiga för att möjliggöra en rimlig avvägning när risken spridning av växtskyddsmedel kan tillåtas och när det inte är rimligt. I handläggningen av tillståndsärenden och avvägningar om det ska råda förbud eller krav på tillstånd är den inte bara spridningen av växtskyddsmedel som behöver beaktas utan även övriga förutsättningar och risker som hanteringen av växtskyddsmedel är förknippad med.
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| 8. |
- Sravani, Musunuri, 1987-, et al.
(författare)
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Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain
- 2016
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 54:4, s. 1671-1686
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Tidskriftsartikel (refereegranskat)abstract
- Background: Alzheimer's disease (AD) is a chronic neurodegenerative disorder accounting for more than 50% of all dementia cases. AD neuropathology is characterized by the formation of extracellular plaques and intracellular neurofibrillary tangles consisting of aggregated amyloid-beta and tau, respectively. The disease mechanism has only been partially elucidated and is believed to also involve many other proteins. Objective: This study intended to perform a proteomic profiling of post mortem AD brains and compare it with control brains as well as brains from other neurological diseases to gain insight into the disease pathology. Methods: Here we used label-free shotgun mass spectrometry to analyze temporal neocortex samples from AD, other neurological disorders, and non-demented controls, in order to identify additional proteins that are altered in AD. The mass spectrometry results were verified by antibody suspension bead arrays. Results: We found 50 proteins with altered levels between AD and control brains. The majority of these proteins were found at lower levels in AD. Pathway analyses revealed that several of the decreased proteins play a role in exocytic and endocytic pathways, whereas several of the increased proteins are related to extracellular vesicles. Using antibody-based analysis, we verified the mass spectrometry results for five representative proteins from this group of proteins (CD9, HSP72, PI42A, TALDO, and VAMP2) and GFAP, a marker for neuroinflammation. Conclusions: Several proteins involved in exo-endocytic pathways and extracellular vesicle functions display altered levels in the AD brain. We hypothesize that such changes may result in disturbed cellular clearance and a perturbed cell-to-cell communication that may contribute to neuronal dysfunction and cell death in AD.
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| 9. |
- Cavazzana, Annachiara, et al.
(författare)
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Sensory-specific impairment among older people : An investigation using both sensory thresholds and subjective measures across the five senses
- 2018
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:8
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Tidskriftsartikel (refereegranskat)abstract
- Age-related sensory impairment is a slow and gradual progress, which affects multiple modalities. Two contradictory hypotheses exist about the age-related decline of sensory thresholds. The common factor theory assumes one underlying factor-which accounts for the loss of several sensory modalities simultaneously-and the specific factor theory predicts that the sensory decline is uncorrelated between different modalities. In this study, we aimed to explore whether (i) there is a common factor of sensory thresholds in older people, (ii) older people assume that sensory decline in one modality also affects other modalities, (iii) there is a relation between sensory threshold and the subjective assessment of sensory function. This was accomplished by collecting both threshold measures and self-reported ratings for smell, hearing, taste, vision, and touch function in a group of 104 older people (mean age: 67.2 years; SD: 9.85; range: 50-100 years). Results indicated that there was no common factor of sensory thresholds, hence an impairment in one modality did not necessarily imply a shortfall in other modalities. In contrast, our results suggested one or two common factor(s) for the participants' ratings. Participants who reported a diminished function in one sense tended to generalize this rating to the other senses as well. The correspondence between subjective ratings and sensory thresholds was relatively good for vision and audition, although no correlations were observed for the other domains. These findings have implications for clinicians, suggesting that subjective measures should be combined with sensory threshold measurements when evaluating sensory dysfunction. Also, these data convey a positive message for older people and their physicians by showing that loss in one sensory modality does not necessarily generalize to losses across all sensory modalities.
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| 10. |
- Ericsson, Malin, et al.
(författare)
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Childhood social class and cognitive aging in the Swedish Adoption/Twin Study of Aging
- 2017
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 114:27, s. 7001-7006
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Tidskriftsartikel (refereegranskat)abstract
- In this report we analyzed genetically informative data to investigate within-person change and between-person differences in late-life cognitive abilities as a function of childhood social class. We used data from nine testing occasions spanning 28 y in the Swedish Adoption/Twin Study of Aging and parental social class based on the Swedish socioeconomic index. Cognitive ability included a general factor and the four domains of verbal, fluid, memory, and perceptual speed. Latent growth curve models of the longitudinal data tested whether level and change in cognitive performance differed as a function of childhood social class. Between-within twin-pair analyses were performed on twins reared apart to assess familial confounding. Childhood social class was significantly associated with mean-level cognitive performance at age 65 y, but not with rate of cognitive change. The association decreased in magnitude but remained significant after adjustments for level of education and the degree to which the rearing family was supportive toward education. A between-pair effect of childhood social class was significant in all cognitive domains, whereas within-pair estimates were attenuated, indicating genetic confounding. Thus, childhood social class is important for cognitive performance in adulthood on a population level, but the association is largely attributable to genetic influences.
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