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- Suzuki, Nobuyuki, 1971, et al.
(författare)
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A suspicious case of drug induced lung injury caused by daikenchuto (TU-100)
- 2016
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Ingår i: Respiration and Circulation. - 0452-3458. ; 64:3, s. 313-318
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Tidskriftsartikel (refereegranskat)abstract
- Background: Daikenchuto has frequently been used for several disorders of digestive system. Case report: 76 years old male had hepatocellular carcinoma and been admitted to our hospital in purpose of an operation of hemihepatectomy. He started to take daikenchuto seven days before the operation. He complained dyspnea on exercise and dry cough on 4th day post operation. Chest X ray and CT showed diffuse ground grass opacity mainly in lower fields of bilateral lungs. In this stage bacterial pneumonia was suspected, but antibiotics did not effectively improve his condition. The lung opacity gradually got worse. We were consulted to see him and suspected it would be drug-induced lung disorder (DILD) caused by Daikenchuto. After cessation of taking Daikenchuto, his symptoms and lung opacity immediately improved. Later, lymphocyte stimulation test with Daikenchuto was proven to be positive, therefore we diagnosed him as having DILD caused by the medicine. Discussion: Although Daikenchuto is the best selling remedy in a field of wakan medicine, there has been a few reports of lung disorder caused by it. When a patient complains any respiratory symptom and diffuse ground grass opacity is observed in chest X-ray or CT after taking Daikenchuto, we should consider it as a cause of drug-induced lung disorder.
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| 2. |
- Suzuki, Shintaro, et al.
(författare)
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An adult case of anaphylaxis caused by allergy to jellyfish
- 2017
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Ingår i: Arerugi Japanese Journal of Allergology. - 0021-4884. ; 66:6, s. 804-808
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Tidskriftsartikel (refereegranskat)abstract
- A 35-year-old female, professional diver, reported nausea, vomiting, and systemic hives 20 to 30 minutes after ingestion of antipasto made with jellyfish. Patient reported prior episodes of swelling after stings from several different creatures, including jelly fish. She also developed a systemic allergic reaction after sting from an unknown creature while diving. On the initial visit to our hospital, serum total IgE level was 545IU/mL We extracted crude allergen from jellyfish and evaluated allergen specific IgE antibody levels using ELISA. Patient samples showed higher levels of jellyfish-derived allergen specific IgE than healthy control samples. Basophils were isolated from the peripheral blood of patient. Stimulation with jellyfish-derived allergen showed expression of surface antigens on basophils increased in a concentration-dependent manner. Methods using sodium dodecyl sulfate poly acrylamide gel electrophoresis and immunoblotting showed acid-soluble collagen fraction from jellyfish contained above 250kDa weighed protein that may have caused this current event. A provocation test using jellyfish samples was not performed due to risk of anaphylactic shock. The patient was diagnosed with a jellyfish allergy due to IgE mediated anaphylaxis after ingestion. She was asked to refrain from consuming any food containing jellyfish. IgE-mediated food allergy caused by jellyfish is rare worldwide. Collagen was speculated to be an allergen in this study. Additional study to detect specific allergens related to jellyfish allergy would be particularly useful to specify disease phenotypes and individual care in future.
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