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Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Urologi och njurmedicin) > Aus Gunnar 1958

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  • Aus, Gunnar, 1958, et al. (författare)
  • Editorial Comments
  • 2008
  • Ingår i: J Urol. ; 4:1, s. 17-18
  • Recension (övrigt vetenskapligt/konstnärligt)
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  • Hugosson, Jonas, 1955, et al. (författare)
  • Mortality results from the Göteborg randomised population-based prostate-cancer screening trial.
  • 2010
  • Ingår i: The lancet oncology. - 1474-5488. ; 11:8, s. 725-32
  • Tidskriftsartikel (refereegranskat)abstract
    • Prostate cancer is one of the leading causes of death from malignant disease among men in the developed world. One strategy to decrease the risk of death from this disease is screening with prostate-specific antigen (PSA); however, the extent of benefit and harm with such screening is under continuous debate.
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  • Schröder, Fritz H, et al. (författare)
  • Screening and prostate-cancer mortality in a randomized European study.
  • 2009
  • Ingår i: The New England journal of medicine. - 1533-4406 .- 0028-4793. ; 360:13, s. 1320-8
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The European Randomized Study of Screening for Prostate Cancer was initiated in the early 1990s to evaluate the effect of screening with prostate-specific-antigen (PSA) testing on death rates from prostate cancer.
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  • Aus, Gunnar, 1958 (författare)
  • Current status of HIFU and cryotherapy in prostate cancer--a review.
  • 2006
  • Ingår i: Eur Urol. - : Elsevier BV. ; 50:5, s. 927-934
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives To evaluate the current status of high-intensity focused ultrasound (HIFU) and cryosurgery as the primary treatment option in patients with prostate cancer. Method A MedLine search using specified search terms was done on February 28, 2005. This search rendered 150 papers related to HIFU and 566 papers related to cryosurgery. Very few of these papers presented original outcome data and are included in the present review. Results No controlled trial was available for analysis, and no survival data were presented. No validated biochemical, surrogate end point was available for any of the two therapies. HIFU showed progression-free survival (based on prostate-specific antigen ± biopsy data) of 63–87% (projected 3- to 5-yr data), but median follow-up in the studies ranged from 12–24 mo. Negative postoperative biopsies was seen in 82–94% of patients. Complications have been reduced by the combination of transurethral resection of the prostate and HIFU. Cryosurgery showed a progression-free survival of 36–92% (projected 1–7 yr data), depending on risk groups and definition of failure. Negative biopsies were seen in 72–87%, but no biopsy data were available for the currently used third-generation cryotherapy machines. Complications seem to be lower with the third-generation machines. Conclusions None of the evaluated therapies has enough data available to support their use as an alternative to established therapies (surgery, radiation) for localised prostate cancer. Until further data become available, the use of both treatments should be restricted to patients unfit for established therapies who still have the need for local therapy. Take Home Message Both HIFU and cryotherapy are used in the treatment of prostate cancer, but there is a profound lack of long-term follow-up data for the currently used treatment modalities. Their use should be limited to patients unfit for conventional therapies.
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