SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Medicinska grundvetenskaper) hsv:(Neurovetenskaper) "

Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Medicinska grundvetenskaper) hsv:(Neurovetenskaper)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Abbas, Abdul-Karim, 1959-, et al. (författare)
  • Long-term potentiation and insult conditioning in hippocampal slices from young rats: a role for protein synthesis under chemical stress?
  • 2010
  • Ingår i: The 10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry (APSN), October 17-20, 2010, Phuket, Thailand.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • We have previously demonstrated that in young rats (12-20-day-old) a sustained long-term potentiation (LTP) can still be induced under conditions of protein synthesis inhibition. It was therefore suggested that sufficient and necessary proteins were already available at the induction time to accomplish LTP maintenance for several hours. Against this background, we have questioned whether hippocampal slices subjected to certain insult conditions might be more sensitive to protein synthesis inhibitors. High K+ concentration has previously been reported to cause an amnesic effect in vivo as well as increasing protein turnover in vitro. We have here employed a K+ insult model under conditions when protein synthesis was inhibited. Recordings were obtained from hippocampal slices for up to 9 h, with or without a cocktail of protein synthesis inhibitors, containing cycloheximide (60 µM) and anisomycin (25 µM). High potassium (50 mM) was transiently applied (5-15 min) shortly after inducing LTP in one of two separate pathways stimulated alternatively. Additionally, an NMDA-receptor antagonist AP5 was supplied after LTP induction to minimize effects related to depolarization-induced glutamate release. Following elimination of all responses for about 30 min, both test and control responses partly recovered. The degree of remaining LTP, defined as test/control ratio, was reduced in both groups of slices (NMDA-independent depotentiation) but was significantly smaller in the drug-treated ones. We are also running an insult model based on oxidative stress, applying hydrogen peroxide (4-5 mM) before or after LTP induction; however, the results are still insufficient for a final conclusion. The potency of cycloheximide, anisomycin or cocktail of the drugs was verified by measurement of incorporation of [3H]-leucine into trichloracetic acid (TCA) precipitable macromolecules. Cycloheximide, anisomycin or cocktail, at concentrations used here caused 95%, 97% and 95% blocking effect, respectively. Our data confirm the idea that sufficient and necessary constitutive proteins are available in the young hippocampus to maintain LTP under conditions of protein synthesis inhibition. They also reveal that LTP in slices subjected to certain insult conditions early after the induction is sensitive to protein synthesis inhibition, probably due to increase in constitutive proteins turnover.
  •  
2.
  • Trägårdh, Karin, et al. (författare)
  • Risk Profiles of Female Perpetrators of Severe Violence
  • 2019
  • Ingår i: 13th Nordic Symposium on Forensic Psychiatry. August 20-22, 2019, Gothenburg.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • Female offenders without a severe mental disorder show more criminogenic factors than those with. Both groups are characterized by mental health problems. We need to further characterize female offenders. Background Offenders of lethal/severe violence are in a majority of cases male, about 90% (Falk et al., 2014), and research has to a considerable extent focused on male violent offenders. Although less is known about female violent offenders than male offenders, previous research has indicated significant differences between male and female offenders of lethal/severe violence (Trägårdh et al., 2016; Yourstone et al., 2008). Since a majority of female perpetrators of lethal violence undergo a forensic psychiatric investigation (RPU/FPI), these documents contains important information about this group. Purpose The aim of this ongoing study is to characterize female perpetrators of severe violent crimes, and to compare female perpetrators sentenced to forensic psychiatric compulsory care with those sentenced to correctional treatment. Method This is an exploratory and descriptive study with a cross-sectional design. All forensic evaluations (FPI) made in Sweden between 2000-2014 (from The National Board of Forensic Medicine/RMV), and the subsequent court verdicts, in cases where women had used lethal/severe violence (n≈180) where used as the basis for data collection in this study. The present preliminary analyses (2-tests and ANOVA) contains approx. 26% (n=47) of the total group. Group differences were investigated regarding: Mental health (FPI) Risk factors (HCR-20 and PCL-R) Victim relation (FPI) Criminal behavior (FPI) Results Female offenders with and without a Severe mental disorder (SMD) seems to differ in some respects. For female offenders with a SMD, the crime was more likely to have been conducted in a less criminal context (see Table). For female offenders without a SMD, the following characteristics were more frequently present: Victim gender – male Substance abuse + Under the influence of substance (offender and victim) Previous violence between victim and offender Previous registered criminality Also, several common features between the SMD and non-SMD group of female offenders were found. The majority of all female offenders had: Previous psychiatric contact and diagnoses Previously attempted suicide No previously registered criminality Conclusions Preliminary results of the female perpetrators who had underwent a FPI seems to identify both substantial differences and similarities between those with versus without a SMD, where those without show more criminogenic factors. Both groups were also characterized by a high amount of mental illness. Also, these results supports previous research that female and male offenders of severe violence differ in important ways. Since a majority of female perpetrators of lethal violence undergo a forensic psychiatric investigation, these results should be generalizable to this group as a whole in Sweden. Based on these results, a great need to further characterize female offenders of severe/lethal violence remain.
3.
  • Mottahedin, Amin (författare)
  • Developing brain and systemic inflammation: a "Toll-like" link with consequences
  • 2017
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. Hypoxia/ischemia (HI), infections and inflammation are implicated in the pathogenesis of PBI. However, the crosstalk between these etiologies is not fully understood. Toll-like receptors (TLR) 3 and TLR2 are responsible for sensing viral and bacterial infections and initiating the inflammatory response. The aim of this thesis was to investigate the effect of systemic inflammation induced by activation of these TLRs on neonatal HI brain injury. We demonstrate that intraperitoneal administration of TLR3 and TLR2 ligands (PolyI:C and P3C, respectively) prior to HI increases the brain injury in neonatal mice. PolyI:C and P3C induced neuroinflammation and altered microglial phenotype as assessed by RT-qPCR, multiplex cytokine assay or flow cytometry. PolyI:C also upregulated the pro-apoptotic gene, Fasl, expression and reduced activation of pro-survival signaling molecule Akt. On the other hand, P3C suppressed mitochondrial respiration, a major mechanism of cellular energy production. P3C, unlike other TLR agonists, induced marked infiltration of leukocytes to the cerebral spinal fluid and brain of neonatal mice and rats. Confocal microscopy, Cre recombinase-mediated gene targeting and in vitro cell transmigra-tion assay revealed the choroid plexus as a site of leukocyte entry. RNA sequencing of the choroid plexus followed by transcriptome cluster analysis and Ingenuity Pathway Analysis revealed potential mechanisms of leukocyte infiltration, including a specific chemotaxis signature and cytoskeleton-related pathways. Finally, we show that N-acetylcysteine treatment inhibits TLR2-mediated leukocyte trafficking in vivo and in vitro. To conclude, this thesis describe a TLR-mediated link between systemic inflammation and developing brain with detrimental consequences on HI brain injury, suggesting potential novel therapeutic strategies.
  •  
4.
  • Deshpande, J, et al. (författare)
  • Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death.
  • 1992
  • Ingår i: Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. - 0014-4819. ; 88:1, s. 91-105
  • Tidskriftsartikel (refereegranskat)abstract
    • The ultrastructural changes in the pyramidal neurons of the CA1 region of the hippocampus were studied 6 h, 24 h, 48 h, and 72 h following a transient 10 min period of cerebral ischemia induced by common carotid occlusion combined with hypotension. The pyramidal neurons showed delayed neuronal death (DND), i.e. at 24 h and 48 h postischemia few structural alterations were noted in the light microscope, while at 72 h extensive neuronal degeneration was apparent. The most prominent early ultrastructural changes were polysome disaggregation, and the appearance of electron-dense fluffy dark material associated with tubular saccules. Mitochondria and nuclear elements appeared intact until frank neuronal degeneration. The dark material accumulated with extended periods of recirculation in soma and in the main trunks of proximal dendrites, often beneath the plasma membrane, less frequently in the distal dendrites and seldom in spines. Protein synthesis inhibitors (anisomycin, cycloheximide) and an RNA synthesis inhibitor (actinomycin D), administered by intrahippocampal injections or subcutanously, did not mitigate neuronal damage. Therefore, DND is probably not apoptosis or a form of programmed cell death. We propose that the dark material accumulating in the postischemic period represents protein complexes, possibly aggregates of proteins or internalized plasma membrane fragments, which may disrupt vital cellular structure and functions, leading to cell death.
  •  
5.
  • Mondal, Tanmoy, et al. (författare)
  • Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory axis
  • 2018
  • Ingår i: Cancer Cell. - 1535-6108. ; 33:3, s. 417-434.e7
  • Tidskriftsartikel (refereegranskat)abstract
    • Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functional synergy between 6p22lncRNAs results in an undifferentiated state that is maintained by a gene-regulatory network, including SOX9 located on 17q, a region frequently gained in NB. 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene. This regulatory nexus between 6p22.3 and 17q regions may lead to potential NB treatment strategies. Mondal et al. show a sense/antisense lncRNA pair expressed from the neuroblastoma (NB) risk-associated 6p22.3 locus is important for retinoic acid-induced NB differentiation gene-regulatory network by controlling CHD7 stability via modulating the cellular localization of the ubiquitin specific protease USP36.
  •  
6.
  •  
7.
  •  
8.
  • Bhandage, Amol K., 1988- (författare)
  • Glutamate and GABA signalling components in the human brain and in immune cells
  • 2016
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • <p>Glutamate and γ-aminobutyric acid (GABA) are the principal excitatory and inhibitory neurotransmitters in the central nervous system (CNS). They both can activate their ionotropic and metabotropic receptors. Glutamate activates ionotropic glutamate receptors (iGlu - AMPA, kainate and NMDA receptors) and GABA activates GABA-A receptors which are modulated by many types of drugs and substances including alcohol. Using real time quantitative polymerase chain reaction, I have shown that iGlu and/or GABA-A receptor subunits were expressed in the hippocampus dentate gyrus (HDG), orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (DL-PFC), central amygdala (CeA), caudate and putamen of the human brain and their expression was altered by chronic excessive alcohol consumption. It indicates that excitatory and inhibitory neurotransmission may have been altered in the brain of human alcoholics. It is possible that changes in one type of neurotransmitter system may drive changes in another. These brain regions also play a role in brain reward system. Any changes in them may lead to changes in the normal brain functions.</p><p>Apart from the CNS, glutamate and GABA are also present in the blood and can be synthesised by pancreatic islet cells and immune cells. They may act as immunomodulators of circulating immune cells and can affect immune function through glutamate and GABA receptors. I found that T cells from human, rat and mouse lymph nodes expressed the mRNAs and proteins for specific GABA-A receptor subunits. GABA-evoked transient and tonic currents recorded using the patch clamp technique demonstrate the functional GABA-A channel in T cells. Furthermore, the mRNAs for specific iGlu, GABA-A and GABA-B receptor subunits and chloride cotransporters were detected in peripheral blood mononuclear cells (PBMCs) from men, non-pregnant women, healthy and depressed pregnant women. The results indicate that the expression of iGlu, GABA-A and GABA-B receptors is related to gender, pregnancy and mental health and support the notion that glutamate and GABA receptors may modulate immune function. Intra- and interspecies variability exists in the expression and it is further influenced by physiological conditions.</p>
  •  
9.
  • Hogenkamp, P S, et al. (författare)
  • Sweet taste perception not altered after acute sleep deprivation in healthy young men.
  • 2013
  • Ingår i: Somnologie : Schlafforschung und Schlafmedizin = Somnology : sleep research and sleep medicine. - 1432-9123. ; 17:2, s. 111-114
  • Tidskriftsartikel (refereegranskat)abstract
    • We hypothesized that acutely sleep-deprived participants would rate ascending concentrations of sucrose as more intense and pleasant, than they would do after one night of normal sleep. Such a finding would offer a potential mechanism through which acute sleep loss could promote overeating in humans.
  •  
10.
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (1396)
Typ av publikation
tidskriftsartikel (6247)
doktorsavhandling (385)
forskningsöversikt (337)
konferensbidrag (294)
bokkapitel (184)
annan publikation (103)
visa fler...
licentiatavhandling (15)
rapport (13)
bok (10)
samlingsverk (redaktörskap) (9)
recension (9)
proceedings (redaktörskap) (1)
visa färre...
Typ av innehåll
refereegranskat (6665)
övrigt vetenskapligt (1290)
populärvet., debatt m.m. (24)
Författare/redaktör
Zetterberg, Henrik, ... (689)
Blennow, Kaj, 1958-, (605)
Hansson, Oskar, (156)
Blennow, K (139)
Brundin, Patrik, (134)
Zetterberg, Henrik, (127)
visa fler...
Blennow, Kaj (127)
Zetterberg, H (120)
Björklund, Anders, (117)
Kirik, Deniz, (104)
Lindvall, Olle, (95)
Nyberg, Lars, (92)
Bäckman, Lars, (84)
Wieloch, Tadeusz, (84)
Schouenborg, Jens, (83)
Cenci Nilsson, Angel ... (79)
Kokaia, Zaal, (75)
Portelius, Erik, 197 ... (73)
Jörntell, Henrik, (72)
Minthon, Lennart, (71)
Andreasson, Ulf, 196 ... (70)
Parmar, Malin, (63)
Wallin, Anders, 1950 ... (57)
Langel, Ülo, (57)
Tatlisumak, Turgut, (56)
Kokaia, Merab, (53)
Petersén, Åsa, (53)
Mattsson, Niklas, (53)
Lindenberger, Ulman (51)
Andreasen, Niels, (50)
Lövdén, Martin (50)
Winblad, Bengt (49)
Mattsson, Niklas, 19 ... (48)
Salami, Alireza, (47)
Heilig, Markus (46)
Skoog, Ingmar, 1954- ... (46)
Hampel, Harald (46)
Schiöth, Helgi B., (44)
Andreasen, N, (44)
Brinkmalm, Gunnar, (43)
Soininen, Hilkka, (43)
Li, Jia-Yi, (42)
Thorsell, Annika, (42)
Kivipelto, Miia, (42)
Gouras, Gunnar K., (41)
Roman, Erika, (41)
Lundberg, Cecilia, (41)
Andersen, Peter M., (40)
Schöll, Michael, 198 ... (40)
Nilsson, Michael, 19 ... (40)
visa färre...
Lärosäte
Göteborgs universitet (2422)
Lunds universitet (2314)
Uppsala universitet (846)
Umeå universitet (670)
Stockholms universitet (544)
Karolinska Institutet (534)
visa fler...
Linköpings universitet (328)
Kungliga Tekniska Högskolan (208)
Chalmers tekniska högskola (169)
Örebro universitet (102)
Sveriges Lantbruksuniversitet (58)
Mittuniversitetet (33)
Linnéuniversitetet (32)
Högskolan Kristianstad (31)
Högskolan i Skövde (30)
Högskolan i Jönköping (16)
swepub_uni:mau_t (16)
Högskolan i Gävle (13)
Högskolan Väst (10)
Södertörns högskola (8)
Högskolan i Borås (4)
Högskolan Dalarna (4)
Gymnastik- och idrottshögskolan (2)
Karlstads universitet (2)
Ersta Sköndal Bräcke högskola (2)
Mälardalens högskola (1)
Blekinge Tekniska Högskola (1)
visa färre...
Språk
Engelska (7411)
Svenska (72)
Tyska (3)
Odefinierat språk (3)
Franska (1)
Ryska (1)
visa fler...
Spanska (1)
Tjeckiska (1)
visa färre...
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (7604)
Naturvetenskap (429)
Samhällsvetenskap (342)
Teknik (88)
Humaniora (51)
Lantbruksvetenskap (7)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy