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Advanced Bioelectronic Materials
- 2015
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- This book covers the recent advances in the development of bioelectronics systems and their potential application in future biomedical applications starting from system design to signal processing for physiological monitoring, to in situ biosensing.Advanced Bioelectronics Materialshas contributions from distinguished international scholars whose backgrounds mirror the multidisciplinary readership ranging from the biomedical sciences, biosensors and engineering communities with diverse backgrounds, interests and proficiency in academia and industry. The readers will benefit from the widespread coverage of the current literature, state-of-the-art overview of all facets of advanced bioelectronics materials ranging from real time monitoring, in situ diagnostics, in vivo imaging, image-guided therapeutics, biosensors, and translational biomedical devices and personalized monitoring.
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- Tiwari, Ashutosh, et al.
(författare)
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Preface
- 2015
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Ingår i: Advanced bioelectronics materials. - Beverly, MA, USA : Wiley-Scrivener. - 9781118998304 - 9781118998861 ; , s. XV-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Turner, Anthony, 1950-
(författare)
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Biosensors for digital health
- 2016
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Ingår i: <em>2016 KSBB Fall Meeting and International Symposium</em>. - Korea : Korean Society for Biotechnology and Bioengineering.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Turner, Anthony, 1950-
(författare)
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Digital Health - The Biochemical Interface : 2016 Datta Medal Lecture
- 2016
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Ingår i: <em>41st FEBS Congress</em>. - : FEBS.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Healthcare spending is growing unsustainably; the USA spends 17.1% of its GDP on healthcare and Sweden 9.7%. Too often, new science implies increased expenditure, but new ideas can both decrease cost and increase effectiveness. Wearable sensors offer a trillion USD market to improve health, but the devices delivered to date havefocussed on relatively easy targets using physical sensors. The real gain will come from monitoring of biochemical parameters that are harder to access in a convenient format. Enhanced awareness of the value of data will spur individuals to acquire and exploit more information about their individual biochemistries, while increasinglysophisticated decision support systems will offer improved diagnostic accuracy and faster information flow. Further drivers are evidence-based reimbursement of treatment costs and the now widely recognised opportunities offered by personalised medicine. Couple all this with the mobility facilitated by telecommunications, and aradical decentralisation and restructuring of national healthcare services, together with the industries serving them, could finally be on the horizon. Biosensors have already proved an enormous success, but far from being a mature technology, we are just on the cusp of a new era. While there are caveats about the usefulness ofsome frequent measurements, new technology is emerging that fuses the mass production of electronics with that that of biochemical assays to yield a plethora of new analytical capabilities. Examples include completely printable diagnostic instruments that can adorn packaging or be worn like a plaster, to contact lensesthat can both sense disease and administer front-line treatment. Advanced functional hybrid materials are enabling the design of reversible affinity sensors and compartmentalised switchable biochemical cascades, while fundamental studies on single-molecule electrochemistry point the way towards new catalyst designs.
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| 6. |
- Turner, Anthony, 1950-
(författare)
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Towards single molecule detection with simple printed instruments
- 2016
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Ingår i: <em>American Advanced Materials Congress</em>. - India : VBRI Press.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- There is now intense pressure on healthcare systems worldwide that will inevitably lead to radical change. Partic ular excitement surrounds the concept of wearable and internetworked analytical devices, but current technology generally falls far short of the sensitivity and specificity required to make further inroads into understanding complex biochemistries and appl ying this knowledge to improving quality of life . Most devices realised to date , utilise derived information from physical sensors and cannot begin to resolve the complexity that can be revealed by molecular sensors. A notable exception is the use of biose nsors for continuous in vivo monitoring and control of diabetes, but progressing beyond this important innovation requires a step change in thinking, since most other desirable analytes offer greater challenges than glucose in terms of the degree of discri mination demanded or the low concentrations present in unprocessed samples . Recent ad vances in single - molecule sens ing enable molecular counting, thus heralding an entirely new , calibration - free quantitative approach able to properly discriminate the heter ogeneities implicit in living systems. Rare and unusual events can be distinguished from the noise a ssociated with ensemble studies and i ndividual inter - and intra - molecular events can be studied in detail . Combining this technique with the simplicity of e lectroanalysis and recent advances in printed electronics allows us to conceive of powerful analytical tools that could be mass produced in a variety of form factors , suitable for emerging markets based around next generation intelligent systems. Add to th is appropriate sampling technology and we may finally be able to access the multifarious biomarkers that could allow us to better maintain health in the face of genetic, nutritional and environmental factors, and to personalise tr eatment of disease with ta ilored pha r maceuticals and bioelectronic medicine. This presentation will review our recent work on single molecule electrochemistry, the design of printed electroanalytical instruments and new approaches to minimally invasive sampling and will speculate o n possible future developments based on combining these leading edge technologies.
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| 7. |
- Uzun, Lokman, et al.
(författare)
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Reactive electrospun nanofibres as a versatile functional material on electrode surfaces for impedimetric sensor design
- 2016
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Ingår i: <em>Proceedings and Abstract Book </em>. - India : VBRI Press. - 9789188252036
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Electrospinning is a highly attractive technique to incorporate functional materials into nanofibre structures. In this process, the polymer structure is transformed from a bulk to a fibrous network by means of a high voltage applied between two-electrode systems.1 The functionality of the bulk polymers defines the functionality of the final nanofibres as well, which is a major limitation for producing ease-to-use electrospun nanofibres.2 For this reason, researchers have focused on reactive electrospinning to produce functional nanofibres with the desired properties. For this aim, an extra step, oligomerisation, is applied to elongate the polymeric chain just before the electrospinning step. In addition, it is possible to adjust the functionality of the final fibres by using an appropriate initial functional monomer.3 Herein, we focused our attention on developing reactive electrospun nanofibres for designing a versatile functional material on electrode surfaces. We have developed a reactive electrospinning process for a functional monomer, glycidyl methacrylate, to obtain epoxy-containing fibres that are ready for immobilisation of a recognition element directly on the surface. After that, Anti-albumin antibody molecules were immobilised on the surface as a recognition element. Then the electrodes were characterised by scanning electron microscopy and Fourier transform infrared spectroscopy. The factors affecting albumin recognition were also evaluated by varying the dipping time, pH, and concentration. The results indicated that anti-albumin antibody molecules were successfully immobilised on the fibres and play an efficient recognition role for albumin detection in aqueous solutions as well as in human serum. In conclusion, the material and method developed here shows promise for the development of versatile sensor platforms, due to its excellent performance, reproducibility and low cost.
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