| 1. |
- Addo, Rebecka N., et al.
(författare)
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Olfactory Functions in Adults With Autism Spectrum Disorders
- 2017
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Ingår i: Perception. - : SAGE Publications. - 0301-0066 .- 1468-4233. ; 46:3-4, s. 530-537
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Tidskriftsartikel (refereegranskat)abstract
- Autism spectrum disorders (ASD) are often characterized by atypical sensory behavior (hyperor hyporeactivity) although evidence is scarce regarding olfactory abilities in ASD; 16 adults with high-functioning ASD (mean age: 38.2, SD: 9.7) and 14 healthy control subjects (mean age: 42.0 years, SD: 12.5) were assessed in odor threshold, free and cued odor identification, and perceived pleasantness, intensity, and edibility of everyday odors. Although results showed no differences between groups, the Bayes Factors (close to 1) suggested that the evidence for no group differences on the threshold and identification tests was inconclusive. In contrast, there was some evidence for no group differences on perceived edibility (BF01 = 2.69) and perceived intensity (BF01 = 2.80). These results do not provide conclusive evidence for or against differences between ASD and healthy controls on olfactory abilities. However, they suggest that there are no apparent group differences in subjective ratings of odors.
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| 2. |
- Airaksinen, Eija, et al.
(författare)
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Cognitive and social functioning in recovery from depression: Results from a population-based three-year follow-up
- 2006
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Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327. ; 96:1-2, s. 107-110
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Tidskriftsartikel (refereegranskat)abstract
- Background: This study prospectively examined cognitive and social functioning in recovery from depression using participants sampled from the general population. Method: Seventy-six depressed persons fulfilling (n=41) and not fulfilling (n=35) the criteria for DSM-IV depression at a threeyear follow-up were compared with respect to episodic memory performance and social functioning at baseline (T1), at follow-up (T2) and change across time. Results: The groups did not differ in episodic memory performance either at T1, T2 or in residual change. However, the groups differed in social functioning at T2 and in residual change indicating improved social functioning in the recovered group. Limitation: The absence of a healthy control group at follow-up. Conclusion: Despite the symptomatic improvement and improved social functioning, cognitive functioning does not follow this general recovery trend, at least not in the three-year interval examined.
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| 3. |
- Airaksinen, Eija, et al.
(författare)
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Low episodic memory performance as a premorbid marker of depression: : Evidence from a 3-year follow-up
- 2007
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Ingår i: Acta Psychiatrica Scandinavica. ; 115:6, s. 458-465
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Objective: To examine low episodic memory scores as a potential risk factor for depression.Method: A population-based sample of non-depressed individuals (20–64 years) were re-examined 3 years after an initial screening (n ¼ 708). At baseline, information on episodic memory scores, demographic and socioeconomic factors, alcohol use and anxiety diagnoses was collected. The data for depression diagnoses were collected at both baseline and follow-up.Results: Logistic regressions, conducted on three separate study groups that were defined according to three assessments of episodic memory (i.e. free + cued recall, free recall, cued recall) among individuals who scored in the 25 lowest or highest percentiles in the memory tests, revealed that low episodic memory performance defined as the sum of free and cued recalls of organizable words constitutes a risk of depression diagnosis 3 years later.Conclusion: Low episodic memory performance predated depressive diagnosis and might be considered as a premorbid marker of depression.
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| 4. |
- Almkvist, Ove, et al.
(författare)
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Odor Identification Across Time in Mutation Carriers and Non-Carriers in Autosomal-Dominant Alzheimer’s Disease
- 2024
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 97:2, s. 587-598
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Tidskriftsartikel (refereegranskat)abstract
- Background: Impaired odor identification is a characteristic of sporadic Alzheimer’sdisease(AD), but its presence in autosomal-dominantAD (adAD) remains uncertain. Objective: To investigate odor identification ability in mutation carriers (MC) and non-carriers (NC) of adAD in relation to years to estimated clinical onset clinical onset (YECO) of disease. Methods: Participants from six families with autosomal-dominant mutations (APP Swedish, APPArctic, and PSEN1 mutations) included 20 MC and 20 NC. The groups were comparable in age, gender, education, number of APOE ɛ4 alleles, and YECO, but differed in global cognition (Mini-Mental State Examination). The MC group included individuals in asymptomatic, symptomatic cognitively unimpaired, mild cognitive impairment, and dementia stages of disease, spanning approximately 40 years of the AD continuum. All NC were asymptomatic. Olfactory function was assessed by means of free and cued identification of common odors summarized as total identification. Results: MC performed poorer than NC in free and total identification. Four MC and none of the NC were anosmic. Olfactory functions in MC and NC were significantly and inversely related to time course (YECO) for both free and total identification. The decline in free identification began approximately 10 years prior to the estimated clinical onset of AD in MC. Odor identification proficiency was associated with episodic memory and executive function in MC and NC. Conclusions: Impaired odor identification is present well before the clinical diagnosis of AD in MC and is associated with disease progression. Odor identification ability may be a useful early biomarker for adAD.
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| 5. |
- Arshamian, Artin, 1979-, et al.
(författare)
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Olfactory awareness is positively associated to odour memory
- 2011
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Ingår i: Journal of Cognitive Psychology. - : Informa UK Limited. - 2044-5911 .- 2044-592X. ; 23:2, s. 220-226
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the relationship between olfactory awareness and olfactory proficiency as determined by a set of standardised olfactory tasks. Olfactory awareness was indexed by scores in questionnaires focusing on odour interest, imagery ability, and prevalence of olfactory dreams. Nineteen subjects with high and 20 subjects with low odour awareness were presented with a set of standardised olfactory tasks: odour threshold, episodic odour recognition, and odour identification. The results showed that individuals with high odour awareness excelled in odour memory and identified more odours as compared with the low awareness group. Interestingly, odour naming ability exerted no influence on odour memory. Furthermore, high odour awareness was not related to a more sensitive olfactory sensory system as determined by olfactory threshold measurements.
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| 6. |
- Arshamian, Artin, 1979-
(författare)
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Olfactory Cognition : The Case of Olfactory Imagery
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The capacity to form olfactory images has received less attention than the formation of visual and auditory images. The evidence in favor of such ability is also inconsistent. This thesis explored some of the characteristics of olfactory imagery through three empirical studies. Study I investigated the effects of blocking spontaneous sniffing during olfactory imagery. The results indicated that the prevention of spontaneous sniffing reduced olfactory but not visual imagery capacity. Study II studied the relation between olfactory awareness (as indexed by olfactory dreams, olfactory imagery, and olfactory interest) and olfactory functions (i.e., odor threshold, episodic odor memory, and odor identification). The main findings were that compared to low, high olfactory awareness was associated with better episodic odor memory and identification, but not with higher olfactory sensitivity. Study III investigated the neural correlates of odor evoked autobiographical memories (OEAMs) as (a) a function of cue modality (i.e., odors and their verbal referents), and (b) a function of memory remoteness. The results from Study III showed that OEAMs activated regions generally associated with autobiographical memory. In addition, verbally cued OEAMs were associated with activity linked to olfactory imagery. Odor cues activated the limbic and temporal polar regions more than verbal cues; a result that may explain the phenomenological differences found between the cued memories. Moreover, OEAMs from the first decade of life were associated with higher activity in the secondary olfactory cortex, whereas memories from young adulthood were related to areas linked to semantic memory processing. Taken together these studies favor the notion of a human capacity to form olfactory images.
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| 7. |
- Arshamian, Artin, et al.
(författare)
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Same same but different : the case of olfactory imagery
- 2014
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 5, s. UNSP 34-
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Tidskriftsartikel (refereegranskat)abstract
- In the present work we present an overview of experimental findings corroborating olfactory imagery observations with the visual and auditory modalities. Overall, the results indicate that imagery of olfactory information share many features with those observed in the primary senses although some major differences are evident. One such difference pertains to the considerable individual differences observed, with the majority being unable to reproduce olfactory information in their mind. Here, we highlight factors that are positively related to an olfactory imagery capacity, such as semantic knowledge, perceptual experience, and olfactory interest that may serve as potential moderators of the large individual variation.
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| 8. |
- Arshamian, Artin, 1979-, et al.
(författare)
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Sniff Your Way to Clarity : The Case of Olfactory Imagery
- 2008
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Ingår i: CHEMOSENSORY PERCEPTION. - : Springer Science and Business Media LLC. - 1936-5802 .- 1936-5810. ; 1:4, s. 242-246
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Tidskriftsartikel (refereegranskat)abstract
- This study addressed the effects of blocking spontaneous sniffing during olfactory imagery. A group of subjects (n=40) who scored high in olfactory focus and imagery ability rated the vividness in olfactory and visual imagery content under conditions of blocked sniffing, blocked vision, and a nonblocked control. The imagery stimuli consisted of 90 common words that could represent either an odor or a visual object. Blocked sniffing was expected to impair olfactory imagery vividness, but since visual imagery entails eye movements, which was not affected by the ""blocked vision"" manipulation, visual imagery ratings were effectively used as a placebo control. Confirming our hypotheses, the results showed that preventing sniffing resulted in a selectively poorer olfactory but not visual vividness, whereas blocked vision showed no effect on either the visual or olfactory vividness ratings. These observations confirm that sensorimotor activity is an important aspect for the quality of evoked olfactory images.
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| 9. |
- Arshamian, Artin, et al.
(författare)
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The functional neuroanatomy of odor evoked autobiographical memories cued by odors and words
- 2013
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Ingår i: Neuropsychologia. - : Elsevier BV. - 0028-3932 .- 1873-3514. ; 51:1, s. 123-131
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Tidskriftsartikel (refereegranskat)abstract
- Behavioral evidence indicates that odor evoked autobiographical memories (OEAMs) are older, more emotional, less thought of and induce stronger time traveling characteristics than autobiographical memories (AMs) evoked by other modalities. The main aim of this study was to explore the neural correlates of AMs evoked by odors as a function of retrieval cue. Participants were screened for specific OEAMs and later presented with the odor cue and its verbal referent in an fMRI paradigm. Because the same OEAM was retrieved across both cue formats (odor and word), potential cue dependent brain activations were investigated. The overall results showed that odor and word cued OEAMs activated regions typically associated with recollection of autobiographical information. Although no odors were presented, a verbal cuing of the OEAMs activated areas associated with olfactory perception (e.g., piriform cortex). However, relative to word cuing, an odor cuing of OEAMs resulted in more activity in MTL regions such as the parahippocampus, and areas involved in visual vividness (e.g., occipital gyrus and precuneus). Furthermore, odor cues activated areas related to emotional processing, such as limbic and tempopolar regions significantly more. In contrast, word cues relative to odor cues recruited a more widespread and bilateral prefrontal activity. Hippocampus activity did not vary as function of the remoteness of the memory, but recollection of OEAMs from the 1st vs the 2nd decade of life showed specific activation in the right OFC, whereas the 2nd reflected a higher activation in the left inferior frontal gyrus.
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| 10. |
- Cavazzana, Annachiara, et al.
(författare)
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Postinfectious olfactory loss : A retrospective study on 791 patients
- 2018
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Ingår i: The Laryngoscope. - : Wiley. - 0023-852X .- 1531-4995. ; 128:1, s. 10-15
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Tidskriftsartikel (refereegranskat)abstract
- Objectives/Hypothesis: Postinfectious olfactory loss is among the most common causes of olfactory impairment and has substantial negative impact on patients' quality of life. Recovery rates have been shown to spontaneously improve in most of patients, usually within 2 to 3 years. However, existing studies are limited by small sample sizes and short follow-up. We aimed to assess the prognostic factors for recovery in a large sample of 791 patients with postinfectious olfactory disorders.Study Design: Retrospective cohort.Methods: We performed a retrospective analysis of 791 patients with postinfectious olfactory loss. Olfactory functions were assessed using the Sniffin' Sticks test at the first and final visits (mean follow-up = 1.94 years).Results: Smell test scores improved over time. In particular, patient's age and the odor threshold (T), odor discrimination (D), and odor identification (I) (TDI) score at first visit were significant predictors of the extent of change. The percentage of anosmic and hyposmic patients exhibiting clinically significant improvement was 46% and 35%, respectively.Conclusions: This study provides new evidence within the postinfectious olfactory loss literature, shedding light on the prognostic factors and showing that recovery of olfactory function is very frequent, even many years after the infection.
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