| 1. |
- Nilsson, Lars-Göran, 1944-, et al.
(författare)
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Challenging the notion of an early-onset of cognitive decline.
- 2009
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Ingår i: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 30:4, s. 521-524; discussion 530
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Salthouse claims that cognitive aging starts around 20 years of age. The basis for this claim is cross-sectional data. He dismisses longitudinal data, which typically show the cognitive decline to start much later, around 60 years of age. He states that longitudinal data cannot be trusted because they are flawed. There is a confounding between the effects of maturation and retest effects. We challenge Salthouse's strong claim on four accounts.
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| 2. |
- Rönnlund, Michael, 1967-, et al.
(författare)
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Predictors of self-reported prospective and retrospective memory in a population-based sample of older adults
- 2011
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Ingår i: The Journal of Genetic Psychology. - : Taylor & Francis. - 0022-1325 .- 1940-0896. ; 172:3, s. 266-284
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Tidskriftsartikel (refereegranskat)abstract
- In this article, the authors examined predictors of self-reported everyday memory failures using the Prospective and Retrospective Questionnaire (PRMQ; Smith, Della Sala, Logie, &Maylor, 2000) in a population-based sample of older adults (age range = 60–90 years; N = 250). The results showed that a higher frequency of reported failures was associated with lower scores on the personality dimension of self-directedness as assessed by the Temperament and Character Inventory (TCI; Cloninger, Dragan, Svrakic,& Przybeck, 1993) and more depressive symptoms on the Center for Epidemiological Studies Depression Scale (CES-D; Radloff, 1977).However, PRMQscores showed no relationships with objective memory ability, as reflected by a series of retrospective memory measures and a measure of prospective memory. Neither were the PRMQ scales associated with general cognitive functioning as assessed by the Mini-Mental State Examination (MMSE; Folstein, Folstein, & McHugh, 1977). Taken together, the results indicate that within the older population, self-reported memory as assessed by the PRMQ may reflect moodstate and personality factors rather than individual differences in memory and cognitive ability.
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| 3. |
- Vestergren, Peter, 1974-, et al.
(författare)
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Development of the cognitive dysfunction questionnaire (CDQ) in a population based sample
- 2011
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Ingår i: Scandinavian Journal of Psychology. - Stockholm : Almqvist & Wiksell. - 0036-5564 .- 1467-9450. ; 52:3, s. 218-228
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Tidskriftsartikel (refereegranskat)abstract
- The study reports on the development of a questionnaire for assessment of adult cognitive dysfunction (CDQ). Participants in a population-based sample(65 ± 15 years, N = 370) responded to a 90-item pilot version covering multiple aspects of memory/cognition. Based on exploratory principal components analyses and correlations with criterion measures of cognitive functioning (MMSE, Block Design, semantic/episodic memory), 20 items loading on 6 components were selected for the final version of the questionnaire. Cronbach’s a for the total score was 0.90. There was evidence of construct validity as judged by correlations between CDQ scores, objective cognitive measures, and a subjective memory measure (PRMQ). Discriminant validity was demonstrated by a low and non-significant correlation with depressive symptoms. Further evidence of construct validity was provided by correlations with age and educational attainment. In conclusion, the CDQ is promising as a self-rating screening tool for cognitive dysfunction, and will be the subject of further development and validation.
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| 4. |
- Vestergren, Peter, 1974-, et al.
(författare)
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Multigroup confirmatory factor analysis of the cognitive dysfunction questionnaire : instrument refinement and measurement invariance across age and sex
- 2012
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Ingår i: Scandinavian Journal of Psychology. - : Wiley-Blackwell. - 0036-5564 .- 1467-9450. ; 53:5, s. 390-400
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Tidskriftsartikel (refereegranskat)abstract
- The study adopted CFA to investigate the factorial structure and reduce the number of items of the Cognitive Dysfunction Questionnaire (CDQ; Vestergren, Rönnlund, Nyberg, & Nilsson, 2011). The analyses were based on data for a total of 1115 participants from population based samples (mean age: 63.0 ± 14.5 years, range: 25 - 95) randomly split into a refinement (n = 569) and a cross-validation (n = 546) sample. Equivalence of the measurement and structural portions of the refined model was demonstrated across the refinement and cross-validation samples. Among competing models the best fitting and parsimonious model had a hierarchical factor structure with five first-order and one second-order general factor. The final version of the CDQ consisted of 20 items in five domains (Procedural actions, Semantic word knowledge, Face recognition, Temporal orientation and Spatial navigation). Internal consistency reliabilities were adequate for the total scale and for the subscales. Multigroup CFAs were performed and the results indicate measurement invariance across age and sex up to the scalar level. Finally, higher levels of cognitive dysfunction as reflected by CDQ scores were observed with advancing age and with deficits in general cognitive functioning as reflected by scores on the Mini-Mental State Examination. In conclusion, adoption of the final version of the CDQ appears to be a way of measuring cognitive dysfunction without administering formal cognitive tests. Future studies should apply it among clinical groups to further test its usefulness.
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| 5. |
- Vestergren, Peter, 1974-, et al.
(författare)
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Perceived causes of everyday memory problems in a population-based sample aged 39–99
- 2011
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Ingår i: Applied Cognitive Psychology. - Chichester : John Wiley & Sons, Ltd.. - 0888-4080 .- 1099-0720. ; 25:4, s. 641-646
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Tidskriftsartikel (refereegranskat)abstract
- There is usually a weak relation between memory complaints and laboratory memory performance, but few studies have investigated what people perceive as causes of their everyday memory problems. This study investigated prevalence, severity and perceived causes of memory problems in a population-based sample (N = 361, age-range 39–99). 30.2 per cent of the participants reported memory complaints (at least moderate memory problems). Higher age was associated with more severe memory problems, but the age-related differences were small. The most frequent perceived causes were age/ageing, stress and multitasking. Age/ageing as a cause was more frequent among older participants, and stress and multitasking were more frequent among middle-aged participants. The results suggest that everyday stress and level of engagement in multiple tasks or commitments, that place demands on cognitive resources, are important variables to consider when studying the relations between subjective everyday memory measures, age and memory performance in the laboratory.
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| 6. |
- Gustavsson, Eva, 1970, et al.
(författare)
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Min plats i biosfären
- 2019
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- “Min plats i biosfären” är en skrift som presenterar forskningsresultat om vilken roll kulturmiljön och de kulturella ekosystemtjänsterna kulturarv och platsidentitet har för människors välbefinnande och för hållbar landskapsförvaltning inom Biosfärområde Vänerskärgården med Kinnekulle. Resultaten i skriften baseras på forskningsprojektet “Kulturmiljö och kulturarv som en del av hållbar landskapsförvaltning” och har genomförts av forskare vid Göteborgs universitet och Högskolan i Gävle.
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| 7. |
- Alaerts, Maaike, et al.
(författare)
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Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population
- 2009
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Ingår i: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. - : John Wiley & Sons, Inc. - 1552-4841 .- 1552-485X. ; 150B:4, s. 585-592
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Tidskriftsartikel (refereegranskat)abstract
- Through active reuptake of serotonin into presynaptic neurons, the serotonin transporter (5-HTT) plays an important role in regulating serotonin concentrations in the brain, and it is the site of binding for tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs). Therefore it has been hypothesized that this transporter is involved in the etiology of bipolar (BP) disorder. Inconsistent association study results for the SLC6A4 gene encoding 5-HTT reported in literature emphasize the need for more systematic and detailed analyses of this candidate gene. We performed an extensive analysis of SLC6A4 on DNA of 254 BPI patients and 364 control individuals from a Northern Swedish isolated population. This analysis consisted of a HapMap LD-based association study including three widely investigated polymorphisms (5-HTTVNTR, 5-HTTLPR, and rs3813034), a copy-number variation (CNV) analysis and a mutation analysis of the complete coding sequence and the 3'-UTR of SLC6A4. No single marker showed statistically significant association with BPI, nor did any of the haplotypes. In the mutation analysis 13 novel variants were detected, including 2 amino acid substitutions M389V and 1587L, but these are probably not implicated in risk for BP. No deletions or duplications were detected in the CNV analysis. We conclude that variation in the SLC6A4 gene or its regulatory regions does not contribute to the susceptibility for BP disorder in the Northern Swedish population.
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| 8. |
- Alaerts, Maaike, et al.
(författare)
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Support for NRG1 as a Susceptibility Factor for Schizophrenia in a Northern Swedish Isolated Population
- 2009
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Ingår i: Archives of General Psychiatry. - : American Medical Association. - 0003-990X .- 1538-3636. ; 66:8, s. 828-837
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Tidskriftsartikel (refereegranskat)abstract
- Context: Neuregulin 1 (NRG1), a growth factor involved in neurodevelopment, myelination, neurotransmitter receptor expression, and synaptic plasticity, first joined the list of candidate genes for schizophrenia when a 7-marker haplotype at the 5' end of the gene (Hap(ICE)) was shown to be associated with the disorder in the Icelandic population. Since then, more genetic and functional evidence has emerged, which supports a role for NRG1 in the development of schizophrenia.Objective: To determine the contribution of NRG1 to susceptibility for schizophrenia in a northern Swedish isolated population.Design: Detailed linkage disequilibrium (LD)-based patient- control association study. This is the first study to type and analyze the 7 Hap(ICE) markers and a set of 32 HapMap tagging single-nucleotide polymorphisms (SNPs) that represents variants with a minor allele frequency of at least 1% and fully characterizes the LD structure of the 5' part of NRG1.Setting: Outpatient and inpatient hospitals.Participants: A total of 486 unrelated patients with schizophrenia and 514 unrelated control individuals recruited from a northern Swedish isolated population.Main Outcome Measures: Association between markers and disease.Results: Analysis of the Hap(ICE) markers showed the association of a 7-marker and 2-microsatellite haplotype, different from the haplotypes associated in the Icelandic population and overrepresented in northern Swedish control individuals. Subsequently, a more detailed analysis that included all 37 genotyped SNPs was performed by investigating haplotypic association, dependent and independent of LD block structure. We found significant association with 5 SNPs located in the second intron of NRG1 (.007 <= P <= .04). Also, 2-, 3-, and 4-SNP windows that comprise these SNPs were associated (P < 3 x 10(-4)). One protective haplotype (0% vs 1.8%; P < 5 x 10(-5)) and 1 disease risk-causing haplotype (40.4% vs 34.9%, P=.02) were defined.Conclusion: The NRG1 gene contributes to the susceptibility for schizophrenia in the northern Swedish population.
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| 9. |
- Andreasson, Anna Nixon, et al.
(författare)
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Inflammation and positive affect are associated with subjective health in women of the general population
- 2013
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Ingår i: Journal of Health Psychology. - : SAGE Publications. - 1359-1053 .- 1461-7277. ; 18:3, s. 311-320
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Tidskriftsartikel (refereegranskat)abstract
- Poor subjective health has been associated with higher levels of inflammatory cytokines. We investigated whether such an association would apply to women of the general population. Levels of cytokines, affect and subjective health were assessed in 347 women of the general population aged 45 to 90 years. Higher levels of interleukin-6 were associated with poor subjective health, especially in participants over 65 years of age. Positive affect was a more robust determinant of subjective health than negative affect. The presence of low-grade inflammation and absence of positive affect, rather than presence of negative affect, may be important determinants of subjective health.
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| 10. |
- Backeström, A., et al.
(författare)
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Glucose metabolism and cognitive dysfunction
- 2010
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Ingår i: Abstracts of the EASD, Stockholm 2010. - : Springer Science and Business Media LLC. ; , s. S292-S292
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Konferensbidrag (refereegranskat)abstract
- Background and aims: The association between type 2 diabetes and different forms of cognitive impairment is well established. The mechanism behind the association is however still unrevealed. We have recently reported that raised blood glucose levels were associated to impairment in episodic memory, the memory function first affected in the progress to dementia. However, patients with type 2 diabetes have not only elevated levels of blood glucose, but also increased levels of insulin because of insulin resistance. It has been suggested that insulin itself might have a negative effect on cognitive function and memory. Diabetes is associated with a long standing hyperglycaemia but also with hypertension and hyperlipideima, leading to micro and macro vascular disease. Thus, our aim was to study whether insulin affects episodic memory independently of glucose in a nondiabetic adult population. Materials and methods: We linked and matched two large population based data sets in Sweden, the Betula study and the Västerbotten Intervention Program. We identified 364 (F/M 207/157, mean age 50.5 ±8.0 years) nondiabetic subjects, free from dementia, who had participated in the two surveys within six months. The memory test included testing of episodic memory. We transformed the results using the mean values and standard deviation from the youngest age group to compute a composite z-score (subjects’ value minus mean score in the 40-year-old group divided by SD). Fasting plasma insulin (FPI) and glucose (FPG) were analyzed with standard methods. Results: Women had higher levels of episodic memory (mean z-score -0.06, SD 0.54) compared to men (mean z-score -0.36, SD 0.51, p<0.001). Given the sex difference in the outcome variable we stratified for sex. In a univariate linear regression both FPG (B -0.274, SE 0.068, Beta -0.271, p<0.001) and FPI (B -0.389, SE 0.131, Beta -0.204, p=0.003) were significantly associated with episodic memory in women but not in men. FPG, but not FPI, remained significantly associated with episodic memory after adjustment for hypertension, total P-cholesterol, bodymass index, educational level, depression, smoking and cardiovascular disease ( FPG: B -0.218, SE 0.070, Beta -0.220, p=0.002; FPI: B -0.232, SE 0.149, Beta -0.127, p=n.s.), when FPG and FPI were analyzed separately. Entering both FPG and FPI into the regression model did not attenuate the association between FPG and episodic memory (FPG: B -0.204, SE 0.071, Beta -0.206, p=0.005). Conclusion: We conclude that an increase in plasma glucose, but not plasma insulin, is associated with impairment in episodic memory in women. This could be explained by a negative effect on the hippocampus caused by raised plasma glucose levels.
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