| 1. |
- Hafid, Abdelakram, et al.
(författare)
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Full Impedance Cardiography Measurement Device Using Raspberry PI3 and System-on-Chip Biomedical Instrumentation Solutions
- 2018
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Ingår i: IEEE journal of biomedical and health informatics. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2168-2194 .- 2168-2208. ; 22:6, s. 1883-1894
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Tidskriftsartikel (refereegranskat)abstract
- Impedance cardiography (ICG) is a noninvasive method for monitoring cardiac dynamics using electrical bioimpedance (EBI) measurements. Since its appearance more than 40 years ago, ICG has been used for assessing hemodynamic parameters. This paper presents a measurement system based on two System on Chip (SoC) solutions and Raspberry PI, implementing both a full three-lead ECG recorder and an impedance cardiographer, for educational and research development purposes. Raspberry PI is a platform supporting Do-I t-Yourself project and education applications across the world. The development is part of Biosignal PI, an open hardware platform focusing in quick prototyping of physiological measurement instrumentation. The SoC used for sensing cardiac biopotential is the ADAS1000, and for the EBI measurement is the AD5933. The recordings were wirelessly transmitted through Bluetooth to a PC, where the waveforms were displayed, and hemodynamic parameters such as heart rate, stroke volume, ejection time and cardiac output were extracted from the ICG and ECG recordings. These results show how Raspberry PI can be used for quick prototyping using relatively widely available and affordable components, for supporting developers in research and engineering education. The design and development documents will be available on www.BiosignalPl.com, for open access under a Non Commercial-Share A like 4.0 International License.
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| 2. |
- Seoane, Fernando, 1976-, et al.
(författare)
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Textile-Friendly Interconnection between Wearable Measurement Instrumentation and Sensorized Garments-Initial Performance Evaluation for Electrocardiogram Recordings.
- 2019
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 19:20
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Tidskriftsartikel (refereegranskat)abstract
- The interconnection between hard electronics and soft textiles remains a noteworthy challenge in regard to the mass production of textile-electronic integrated products such as sensorized garments. The current solutions for this challenge usually have problems with size, flexibility, cost, or complexity of assembly. In this paper, we present a solution with a stretchable and conductive carbon nanotube (CNT)-based paste for screen printing on a textile substrate to produce interconnectors between electronic instrumentation and a sensorized garment. The prototype connectors were evaluated via electrocardiogram (ECG) recordings using a sensorized textile with integrated textile electrodes. The ECG recordings obtained using the connectors were evaluated for signal quality and heart rate detection performance in comparison to ECG recordings obtained with standard pre-gelled Ag/AgCl electrodes and direct cable connection to the ECG amplifier. The results suggest that the ECG recordings obtained with the CNT paste connector are of equivalent quality to those recorded using a silver paste connector or a direct cable and are suitable for the purpose of heart rate detection.
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| 3. |
- Lui, Hoi-Shun, et al.
(författare)
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On the matching medium for microwave stroke diagnosis
- 2019
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Ingår i: Biomedical Physics and Engineering Express. - : IOP Publishing. - 2057-1976. ; 5:4
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Tidskriftsartikel (refereegranskat)abstract
- The choice of matching medium can directly affect the amount of power transmitted into and through human bodies, which impacts on the quality of the reconstructed images in microwave-based medical imaging, and thus the diagnosis accuracies. In this paper, the amount of the transmitted and reflected power of multi-layer planar healthy and hemorrhagic stroke brain models under different choices of matching medium are determined. These multi-layer planar brain tissue models are made up of at least 17 tissue layers with realistic dielectric properties. A layer of blood with different thickness is introduced to model the case of hemorrhagic stroke. Our results show that matching medium with low relative permittivity provides better intrinsic contrast between healthy brain and hemorrhagic brain. Analysis on how the reflection coefficient and transmittance vary under different matching medium are included to provide better insights to the findings.
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| 4. |
- Zeng, Xuezhi, 1980, et al.
(författare)
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Investigation of an ultra wideband noise sensor for health monitoring
- 2020
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 20:4
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Tidskriftsartikel (refereegranskat)abstract
- Quick on-scene assessment and early intervention is the key to reduce the mortality of stroke and trauma patients, and it is highly desirable to develop ambulance-based diagnostic and monitoring devices in order to provide additional support to the medical personnel. We developed a compact and low cost ultra wideband noise sensor for medical diagnostics and vital sign monitoring in pre-hospital settings. In this work, we demonstrated the functionality of the sensor for respiration and heartbeat monitoring. In the test, metronome was used to manipulate the breathing pattern and the heartbeat rate reference was obtained with a commercial electrocardiogram (ECG) device. With seventeen tests performed for respiration rate detection, sixteen of them were successfully detected. The results also show that it is possible to detect the heartbeat rate accurately with the developed sensor.
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| 5. |
- Capece, Sabrina, et al.
(författare)
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A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices
- 2013
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Ingår i: Chemical Communications. - 1359-7345 .- 1364-548X. ; 49:51, s. 5763-5765
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Tidskriftsartikel (refereegranskat)abstract
- Fabrication of multifunctional ultrasound contrast agents (UCAs) has been recently addressed by several research groups. A versatile strategy for the synthesis of UCA precursors in the form of biodegradable vesicles with a biocompatible crosslinked polymer shell is described. Upon ultrasound irradiation, acoustic droplet vaporization transforms such particles into microbubbles behaving as UCAs. This proof of concept entails the features of a potential theranostic microdevice.
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| 6. |
- Abayazid, Fady, et al.
(författare)
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A New Assessment of Bicycle Helmets: The Brain Injury Mitigation Effects of New Technologies in Oblique Impacts
- 2021
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Ingår i: Annals of Biomedical Engineering. - : Springer Science and Business Media LLC. - 1573-9686 .- 0090-6964. ; 49:10, s. 2716-2733
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Tidskriftsartikel (refereegranskat)abstract
- New helmet technologies have been developed to improve the mitigation of traumatic brain injury (TBI) in bicycle accidents. However, their effectiveness under oblique impacts, which produce more strains in the brain in comparison with vertical impacts adopted by helmet standards, is still unclear. Here we used a new method to assess the brain injury prevention effects of 27 bicycle helmets in oblique impacts, including helmets fitted with a friction-reducing layer (MIPS), a shearing pad (SPIN), a wavy cellular liner (WaveCel), an airbag helmet (Hövding) and a number of conventional helmets. We tested whether helmets fitted with the new technologies can provide better brain protection than conventional helmets. Each helmeted headform was dropped onto a 45° inclined anvil at 6.3 m/s at three locations, with each impact location producing a dominant head rotation about one anatomical axes of the head. A detailed computational model of TBI was used to determine strain distribution across the brain and in key anatomical regions, the corpus callosum and sulci. Our results show that, in comparison with conventional helmets, the majority of helmets incorporating new technologies significantly reduced peak rotational acceleration and velocity and maximal strain in corpus callosum and sulci. Only one helmet with MIPS significantly increased strain in the corpus collosum. The helmets fitted with MIPS and WaveCel were more effective in reducing strain in impacts producing sagittal rotations and a helmet fitted with SPIN in coronal rotations. The airbag helmet was effective in reducing brain strain in all impacts, however, peak rotational velocity and brain strain heavily depended on the analysis time. These results suggest that incorporating different impact locations in future oblique impact test methods and designing helmet technologies for the mitigation of head rotation in different planes are key to reducing brain injuries in bicycle accidents.
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| 7. |
- Andersen, L. M., et al.
(författare)
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On-scalp MEG SQUIDs are sensitive to early somatosensory activity unseen by conventional MEG
- 2020
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Ingår i: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 221
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Tidskriftsartikel (refereegranskat)abstract
- Magnetoencephalography (MEG) has a unique capacity to resolve the spatio-temporal development of brain activity from non-invasive measurements. Conventional MEG, however, relies on sensors that sample from a distance (20–40 mm) to the head due to thermal insulation requirements (the MEG sensors function at 4 K in a helmet). A gain in signal strength and spatial resolution may be achieved if sensors are moved closer to the head. Here, we report a study comparing measurements from a seven-channel on-scalp SQUID MEG system to those from a conventional (in-helmet) SQUID MEG system. We compared the spatio-temporal resolution between on-scalp and conventional MEG by comparing the discrimination accuracy for neural activity patterns resulting from stimulating five different phalanges of the right hand. Because of proximity and sensor density differences between on-scalp and conventional MEG, we hypothesized that on-scalp MEG would allow for a more high-resolved assessment of these activity patterns, and therefore also a better classification performance in discriminating between neural activations from the different phalanges. We observed that on-scalp MEG provided better classification performance during an early post-stimulus period (10–20 ms). This corresponded to the electroencephalographic (EEG) component P16/N16 and was an unexpected observation as this component is usually not observed in conventional MEG. This finding shows that on-scalp MEG enables a richer registration of the cortical signal, indicating a sensitivity to what are potentially sources in the thalamo-cortical radiation. We had originally expected that on-scalp MEG would provide better classification accuracy based on activity in proximity to the P60m component compared to conventional MEG. This component indeed allowed for the best classification performance for both MEG systems (60–75%, chance 50%). However, we did not find that on-scalp MEG allowed for better classification than conventional MEG at this latency. We suggest that this absence of differences is due to the limited sensor coverage in the recording, in combination with our strategy for positioning the on-scalp MEG sensors. We show how the current sensor coverage may have limited our chances to register the necessary between-phalange source field dissimilarities for fair hypothesis testing, an approach we otherwise believe to be useful for future benchmarking measurements. © 2020 The Authors
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| 8. |
- Bado, Mattia Francesco, et al.
(författare)
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Distributed optical fiber sensing bonding techniques performance for embedment inside reinforced concrete structures
- 2020
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 20:20, s. 1-23
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Tidskriftsartikel (refereegranskat)abstract
- Distributed optical fiber sensors (DOFS) are modern-day cutting-edge monitoring tools that are quickly acquiring relevance in structural health monitoring engineering. Their most ambitious use is embedded inside plain or reinforced concrete (RC) structures with the scope of comprehending their inner-workings and the functioning of the concrete-reinforcement interaction. Yet, multiple studies have shown that the bonding technique with which the DOFS are bonded to the reinforcement bars has a significant role on the quality of the extracted strain data. Whilst this influence has been studied for externally bonded DOFS, it has not been done for embedded ones. The present article is set on performing such study by monitoring the strain measurement quality as sampled by DOFS bonded to multiple rebars with different techniques and adhesives. These instrumented rebars are used to produce differently sized RC ties later tested in tension. The discussion of the test outputs highlights the quasi-optimal performance of a DOFS/rebar bonding technique consisting of incising a groove in the rebar, positioning the DOFS inside it, bonding it with cyanoacrylate and later adding a protective layer of silicone. The resulting data is mostly noisefree and anomalies-free, yet still presents a newly diagnosed hitch that needs addressing in future research.
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| 9. |
- Candefjord, Stefan, 1981, et al.
(författare)
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A wearable microwave instrument can detect and monitor traumatic abdominal injuries in a porcine model
- 2021
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322 .- 2045-2322. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Abdominal injury is a frequent cause of death for trauma patients, and early recognition is essential to limit fatalities. There is a need for a wearable sensor system for prehospital settings that can detect and monitor bleeding in the abdomen (hemoperitoneum). This study evaluates the potential for microwave technology to fill that gap. A simple prototype of a wearable microwave sensor was constructed using eight antennas. A realistic porcine model of hemoperitoneum was developed using anesthetized pigs. Ten animals were measured at healthy state and at two sizes of bleeding. Statistical tests and a machine learning method were used to evaluate blood detection sensitivity. All subjects presented similar changes due to accumulation of blood, which dampened the microwave signal (p< 0.05). The machine learning analysis yielded an area under the receiver operating characteristic (ROC) curve (AUC) of 0.93, showing 100% sensitivity at 90% specificity. Large inter-individual variability of the healthy state signal complicated differentiation of bleedings from healthy state. A wearable microwave instrument has potential for accurate detection and monitoring of hemoperitoneum, with automated analysis making the instrument easy-to-use. Future hardware development is necessary to suppress measurement system variability and enable detection of smaller bleedings.
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| 10. |
- Candefjord, Stefan, et al.
(författare)
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Combining fibre optic Raman spectroscopy and tactile resonance measurement for tissue characterization
- 2010
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Ingår i: Measurement science and technology. - : IOP Publishing Ltd. - 0957-0233 .- 1361-6501. ; 21:125801, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- Tissue characterization is fundamental for identification of pathological conditions. Raman spectroscopy (RS) and tactile resonance measurement (TRM) are two promising techniques that measure biochemical content and stiffness, respectively. They have potential to complement the golden standard-–histological analysis. By combining RS and TRM, complementary information about tissue content can be obtained and specific drawbacks can be avoided. The aim of this study was to develop a multivariate approach to compare RS and TRM information. The approach was evaluated on measurements at the same points on porcine abdominal tissue. The measurement points were divided into five groups by multivariate analysis of the RS data. A regression analysis was performed and receiver operating characteristic (ROC) curves were used to compare the RS and TRM data. TRM identified one group efficiently (area under ROC curve 0.99). The RS data showed that the proportion of saturated fat was high in this group. The regression analysis showed that stiffness was mainly determined by the amount of fat and its composition. We concluded that RS provided additional, important information for tissue identification that was not provided by TRM alone. The results are promising for development of a method combining RS and TRM for intraoperative tissue characterization.
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