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Träfflista för sökning "hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) srt2:(1990-1999);srt2:(1992)"

Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) > (1990-1999) > (1992)

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  • Karlsson, Magnus K, et al. (författare)
  • Silicone rubber implants for arthrosis of the scaphotrapezial joint
  • 1992
  • Ingår i: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. - Taylor & Francis. - 1651-2073. ; 26:2, s. 173-176
  • Tidskriftsartikel (refereegranskat)abstract
    • Between 1980 and 1983, 10 patients received high performance silicone rubber condylar implants for the treatment of isolated degenerative changes of the scaphotrapezial joint. Early clinical and radiographic results (at a mean of 15 months) were excellent. Late follow up of these 10 together with a further 11 patients, however, showed migration of the implant and radiological signs of silicone particle synovitis in all but two. We no longer recommend this operation for treatment of isolated arthrosis of the scaphotrapezial joint.
  • Nilsson, Ola, 1957-, et al. (författare)
  • Praomys (Mastomys) natalensis: a model for gastric carcinoid formation.
  • 1992
  • Ingår i: The Yale journal of biology and medicine. - 0044-0086. ; 65:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The gastric carcinoid tumors of Praomys (Mastomys) natalensis have been reviewed with respect to histogenesis, development, biochemistry, and morphological properties. Multicentric gastric carcinoids frequently develop in the oxyntic mucosa of aging Mastomys. The development of these tumors can be significantly enhanced by drug-induced hypergastrinemia, e.g., histamine2-receptor blockade. Spontaneous and drug-induced gastric carcinoids are endocrine in nature, as evidenced by their argyrophilic staining properties and chromogranin A content. They are also rich in histidine decarboxylase activity and produce large amounts of histamine, although other hormones, such as peptide YY and enteroglucagon, have also been demonstrated in these tumors. Ultrastructurally, gastric carcinoids are composed of tumor cells with typical secretory granules resembling those of enterochromaffin-like (ECL) cells. A close examination of the gastric carcinoids in Mastomys reveals striking similarities with gastric carcinoids developing in humans suffering from chronic atrophic gastritis type A or from the Zollinger-Ellison syndrome in combination with multiple endocrine neoplasia type 1 (MEN-1). Both these conditions are associated with hypergastrinemia and a higher risk for developing multi-centric gastric carcinoids of ECL-cell origin. The Mastomys tumor model therefore appears to be a significant experimental model in which induction and formation of gastric carcinoid tumors can be studied.
  • Mätzsch, Thomas, et al. (författare)
  • Laparoscopic cholecystectomy in a patient with hemophilia B
  • 1992
  • Ingår i: Surgical Laparoscopy & Endoscopy. - Lippincott Williams & Wilkins. - 1051-7200. ; 2:4, s. 339-340
  • Tidskriftsartikel (refereegranskat)abstract
    • Surgical procedures in hemophiliacs is a demanding challenge for the surgeon and hematologist. This report deals with a successful laparoscopic cholecystectomy in a young patient with hemophilia B. Despite a prolonged operation time, because of a partially intrahepatic gallbladder, no bleeding complications were registered and the patient recovered well. Laparoscopic cholecystectomy seems to be the method of choice in hemophiliacs, as it minimizes tissue trauma. Nevertheless, the procedure should be performed only in specialized centers with a fully equipped coagulation laboratory and a team of surgeons and hematologists familiar with the special problems of surgery in hemophiliacs.
  • Ekelund, Ulf, et al. (författare)
  • Myogenic vascular regulation in skeletal muscle in vivo is not dependent of endothelium-derived nitric oxide
  • 1992
  • Ingår i: Acta Physiologica Scandinavica. - Wiley-Blackwell. - 0001-6772. ; 144:2, s. 199-207
  • Tidskriftsartikel (refereegranskat)abstract
    • The hypothesis, based on in vitro experiments on large conduit arteries, that endothelium-derived nitric oxide is a mediator of vascular myogenic reactivity was tested in cat gastrocnemius muscle in vivo. This was done by comparing, in the absence and presence of effective endothelium-derived nitric oxide blockade by the specific inhibitors NG-monomethyl-L-arginine or NG-nitro-L-arginine methyl ester, myogenic responses in defined consecutive vascular sections to dynamic vascular transmural pressure stimuli, to arterial occlusion (reactive hyperaemia), and to arterial pressure changes (autoregulation of blood flow and capillary pressure). The results demonstrated that the myogenic vascular reactivity to quick ramp transmural pressure stimuli was not attenuated by endothelium-derived nitric oxide blockade, but rather reinforced. The amplitude of the reactive hyperaemia response was unaffected by endothelium-derived nitric oxide blockade, but its duration was shortened because of faster myogenic constriction, especially of large-bore arterial resistance vessels greater than 25 microns, in the recovery phase. Both the improved myogenic responsiveness to transmural pressure stimuli and the shortening of the reactive hyperaemia by endothelium-derived nitric oxide blockade suggested that endothelium-derived nitric oxide released in vivo acts as a 'metabolic' factor which certainly does not improve, but rather depresses myogenic vascular reactivity. Autoregulation of blood flow and capillary pressure were well preserved in the presence of endothelium-derived nitric oxide blockade. It was concluded from the results of these multifaceted tests that myogenic vascular regulation in skeletal muscle in vivo seems independent of endothelium-derived nitric oxide.(ABSTRACT TRUNCATED AT 250 WORDS)
  • Sahlén, Birgitta, et al. (författare)
  • Patterns of vulnerability of language in children with severe developmental language disorders
  • 1992
  • Ingår i: Scandinavian Journal of Logopedics & Phoniatrics. - Scandinavian University Press. - 0803-5032. ; 17:2, s. 77-85
  • Tidskriftsartikel (refereegranskat)abstract
    • Language disordered children with receptive language problems have worse outcome and also more severe problems in other areas of language than children with isolated expressive problems according to “the hypothesis of hierarchical vulnerability” formulated by Bishop and Edmundson (1987). We studied ten children with specific and severe developmental language disorders (DLD) longitudinally and found that the hypothesis was tenable with regard to the predictions about outcome. We also found that among children in the phonologic-syntactic subgroup (Rapin and Allen, 1983), children with poor comprehension and poor lexical-semantic ability had the most severe problems of syntax. Phonological production at ages 5 or 6 was not correlated to phonological production at age 8. Oral motor function, however, turned out to be an important prognostic factor for phonological outcome. The present findings call for revised methodological routines and therapeutical priorities regarding children with severe DLD.
  • Abrahamsson, S. O., et al. (författare)
  • Restoration of the injured flexor tendon surface : A possible role for endotenon cells. A morphological study of the rabbit tendon in vivo
  • 1992
  • Ingår i: Journal of Hand Surgery (British Volume). - SAGE Publications. - 0266-7681. ; 17:5, s. 553-560
  • Tidskriftsartikel (refereegranskat)abstract
    • The ability of rabbit deep flexor tendons to restore the gliding surface and to heal, without the normal contribution of the superficial epitenon layer of the tendons, was studied by light and scanning electron microscopy. The epitenon layer was carefully removed, from defined segments of the tendons. The remaining central tendon tissue was divided, sutured and placed in diffusion chambers subcutaneously in the back of the rabbits. After two weeks of culture, most of the sutured gaps were bridged and the tendons were encapsulated by flattened and spindle-shaped cells which covered a random network of thin collagen fibres. After five and 11 weeks, fibroblast-like cells in multiple layers formed a cobblestone-like surface. Thus, a tendon deprived of its epitenon layer still contains cells which can produce collagen bridge the gap and restore the injured tendon surface.
  • Ahlman, Håkan, 1947-, et al. (författare)
  • Aspects on diagnosis and treatment of the foregut carcinoid syndrome.
  • 1992
  • Ingår i: Scandinavian journal of gastroenterology. - 0036-5521. ; 27:6, s. 459-71
  • Tidskriftsartikel (refereegranskat)abstract
    • Eight patients with the foregut carcinoid syndrome (two gastric and six bronchial primary tumors) are reported. The patients presented with complex clinical symptoms including ectopic production of adrenocorticotrophic hormone and growth hormone-releasing factors. The most alarming symptoms were facial flush and edema, accompanied by severe bronchoconstriction, which easily was misinterpreted as asthmatic attacks. Conventional bronchodilatory drugs may be potentially dangerous in these patients, in whom combined blockade of histamine receptors and treatment with cortisone and octreotide are recommended. Owing to the patients' age and general condition individualized long-term therapy was instituted. Surgical therapy under optimal protection by drugs can be of substantial value also in patients with advanced disease. One patient with life-threatening hormonal symptoms underwent hyperthermic perfusion of the liver with cytotoxic drugs, resulting in good palliation.
  • Elmståhl, Sölve, et al. (författare)
  • Autonomic cardiovascular responses to tilting in patients with alzheimer's disease and in healthy elderly women
  • 1992
  • Ingår i: Age and Ageing. - Oxford University Press. - 0002-0729. ; 21:4, s. 301-307
  • Tidskriftsartikel (refereegranskat)abstract
    • The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no age-associated decrease in the healthy control women. During rest, the AD patients had lower mean systolic and diastolic blood pressure but the same heart rate as the control patients. After tilting, the AD patients had a greater increase in heart rate, and the mean systolic blood pressure fell to 126 mmHg compared with 160 mmHg in the control women (p<0.001). After the initial acceleration, the following deceleration of the heart rate, an expression of parasympathetic nervous activity, was lower in the AD patients (p <0.001). The deep-breathing test showed no significant difference between the two groups, but the changes of acceleration and brake indices could indicate a dysfunction of the autonomic nervous system since the AD patients were not recumbent.
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