| 1. |
- Geborek, Pierre, et al.
(författare)
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Measurement of oxygen and carbon dioxide partial pressures in synovial fluid after tonometry
- 1988
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Ingår i: Clinical Physiology. - 1365-2281. ; 8:4, s. 427-432
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Tidskriftsartikel (refereegranskat)abstract
- A commercially available gas analyser was used to measure tension of oxygen (PO2) and carbon dioxide (PCO2) in synovial fluid samples after tonometry. Measured values of PCO2 were close to the expected (median difference 0.2 kPa, range -0.4 to 0.4) within the analysed concentration range of 4-10 kPa. No consistent difference between measured and expected values of PO2 were found for oxygen in the range 3-11 kPa (median difference 0.1 kPa, range -0.3 to 1.2). For oxygen tensions below 3 kPa, however, the measured values invariably overestimated the actual PO2, the errors ranging from 0.3 to 1.9 kPa, median 1.1. The importance of proper handling of samples was investigated and storage for 1 h at 0 degrees C in plastic syringes resulted in elevation of the PO2 levels measured (range of elevation 0.2 to 3.6 kPa, median 1.15), whilst no significant differences were found when stored in glass syringes. Within the limits stated, commercially available gas analysers may thus be used to investigate these parameters related to local tissue metabolism in effusive joint conditions.
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| 2. |
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| 3. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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Acetylator phenotypes in rheumatoid-arthritis patients with or without adverse drug-reactions to sodium-aurothiomalate or d-penicillamine
- 1987
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Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 16:4, s. 235-239
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Tidskriftsartikel (refereegranskat)abstract
- The acetylator phenotype was determined in 59 patients with classical, seropositive and erosive rheumatoid arthritis (RA) treated with sodium-aurothiomalate or d-penicillamine. Patients with adverse drug reactions (ADR) leading to drug withdrawal (n=29) were compared with a group of patients without ADR (n=30). The frequency of slow acetylators was significantly (p< 0.05) increased in all RA patients, irrespective of the presence of ADR, particularly in the male patients, compared with a control population. No association was found between acetylator phenotype and clinical data or secondary Sjögrens's syndrome (SS).
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| 4. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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Clinical symptoms and HLA antigens in a family with reiters disease
- 1985
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Ingår i: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 14:2, s. 149-158
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Tidskriftsartikel (refereegranskat)abstract
- A clinical and immunogenetic study was performed on a three-generation family with Reiter's disease (RD). Twelve of 56 members of the family (33 clinically examined) including one in-law, had symptoms of arthritis, urethritis, conjunctivitis, uveitis, and/or mucocutaneous manifestations, but only one had the complete triad of Reiter's syndrome (RS). Radiographic sacro-iliitis was found in 7 individuals, and monoarticular onset was reported in 5 out of 7 with peripheral arthritis. HLA B27 was found in 26 of the 37 family members who were tissue typed (including one in-law). All individuals with RD were B27-positive. Seven different B27 phenotypes were identified. This finding suggests that RD is associated with the B27 antigen itself, and not to a gene closely linked to B27. From a pedigree analysis of this family an autosomal dominant inheritance with incomplete penetrance or multifactorial inheritance seemed the most probable alternatives. The family history is a useful adjunct in the diagnosis of RD.
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| 5. |
- Dahlqvist, Solbritt Rantapää
(författare)
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Genetic-markers in rheumatoid-arthritis
- 1986
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Ingår i: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 15:Suppl. 58, s. 1-29
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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HLA antigens in rheumatoid-arthritis patients with and without a family history of polyarthritis
- 1985
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Ingår i: Scandinavian Journal of Rheumatology. - 0300-9742 .- 1502-7732. ; 14:4, s. 375-380
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Tidskriftsartikel (refereegranskat)abstract
- The HLA antigens, A, B and DR, were studied in 141 patients with erosive, seropositive rheumatoid arthritis (RA). The frequency of the B27 antigen was significantly increased among patients with a family history of symmetrical polyarthritis compared with blood donor controls (p<0.001) and with patients without a family history of polyarthritis (p<0.005). The frequency of DR4 was significantly (p<0.001) increased among the RA patients, but there was no significant association between DR4 and a family history of polyarthritis.
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| 7. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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HLA-B27 and involvement of sacroiliac joints in rheumatoid-arthritis
- 1984
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Ingår i: Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 11:1, s. 27-32
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Tidskriftsartikel (refereegranskat)abstract
- The frequency of radiographic signs of sacroiliac joint involvement (greater than or equal to 2 and greater than or equal to 3 according to the New York criteria) was significantly higher in 28 HLA-B27 positive patients with classical seropositive rheumatoid arthritis (RA), than in 28 B27 negative RA controls. The B27 positive RA patients had more subcutaneous nodules (p less than 0.01), worse functional class (p less than 0.05), and higher levels of erythrocyte sedimentation rate (ESR) (p less than 0.05) and haptoglobin (p less than 0.05). Sacroiliitis, independent of HLA-B27, was associated with higher levels of ESR (p less than 0.05), and with a higher frequency of positive ANA test (p less than 0.05). It is neither related to the functional class nor to the duration of the disease
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| 8. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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HLA haplotypes in a family with ankylosing-spondylitis and rheumatoid-arthritis
- 1985
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Ingår i: Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 12:3, s. 518-522
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Tidskriftsartikel (refereegranskat)abstract
- HLA haplotypes (including A, B, C and DR loci) were studied in a family with members who had both rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Sacroiliitis was found in 7 family members, one of whom had AS and 2 others erosive, seropositive RA. They carried the B27-DR4 haplotype, suggesting a possible dual genetic association of the same haplotype in both RA and AS. Three other different HLA-B27 containing haplotype were found, 2 of which could be associated with sacroiliitis/AS. Within this family sacroiliitis and/or AS rather seemed associated with the B27 antigen itself than with the same haplotype.
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| 9. |
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| 10. |
- Dahlqvist, Solbritt Rantapää, et al.
(författare)
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Serum-protein markers in systemic lupus-erythematosus
- 1988
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Ingår i: Human Heredity. - : S. Karger AG. - 0001-5652 .- 1423-0062. ; 38:1, s. 44-47
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Tidskriftsartikel (refereegranskat)abstract
- Serum protein markers (α1-AT, Bf, C3, C4A, C4B, Hp and Tf) were studied in a series of 36 patients with systemic lupus erythematosus (SLE) and compared to normal blood donors. In agreement with the results of previous investigations a significant increase of complement C4 deficiency was found among the SLE patients. The relative risks for AQO and BQ0 homozygosity were 7.2 and 4.1, respectively. Simultaneous occurrence of AQO and BQ0 was found in three patients with a calculated relative risk of about 65. A significant increase of the haptoglobin type 2–2 (p < 0.05) was found among SLE patients. The remaining serum protein systems showed no statistically significant associations with SLE.
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