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Discovery of new bi...
Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip.
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Sundström, Johan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Stenemo, Markus (författare)
- Uppsala universitet,Molekylär epidemiologi
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- Hagström, Emil (författare)
- Uppsala universitet,Kardiologi
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- Ärnlöv, Johan, 1970- (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala university,Institutionen för medicinska vetenskaper,Dalarna Univ, Dept Hlth & Social Sci, Falun, Sweden.
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(creator_code:org_t)
- 2016-09-08
- 2017
- Engelska.
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Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 103:5, s. 377-382
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Apart from several established clinical risk factors for atrial fibrillation (AF), a number of biomarkers have also been identified as potential risk factors for AF. None of these have so far been adopted in clinical practice.OBJECTIVE: To use a novel custom-made proteomics chip to discover new prognostic biomarkers for AF risk.METHODS: In two independent community-based cohorts (Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (978 participants without AF, mean age 70.1 years, 50% women, median follow-up 10.0 years) and Uppsala Longitudinal Study of Adult Men (ULSAM) (n=725, mean age 77.5 years, median follow-up 7.9 years)), ninety-two plasma proteins were assessed at baseline by a proximity extension assay (PEA) chip. Of those, 85 proteins showed a call rate >70% in both cohorts.RESULTS: Thirteen proteins were related to incident AF in PIVUS (148 events) using a false discovery rate of 5%. Of those, five were replicated in ULSAM at nominal multivariable p value (123 events, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), fibroblast growth factor 23 (FGF-23), fatty acid-binding protein 4 (FABP4), growth differentiation factor 15 (GDF-15) and interleukin-6 (IL-6)). Of those, NT-pro-BNP and FGF-23 were also associated with AF after adjusting for established AF risk factors. In a prespecified secondary analysis pooling the two data sets, T-cell immunoglobulin and mucin domain 1 (TIM-1) and adrenomedullin (AM) were also significantly related to incident AF in addition to the aforementioned five proteins (Bonferroni-adjustment). The addition of NT-pro-BNP to a model with established risk factors increased the C-statistic from 0.605 to 0.676 (p<0.0001).CONCLUSIONS: Using a novel proteomics approach, we confirmed the previously reported association between NT-pro-BNP, FGF-23, GDF-15 and incident AF, and also discovered four proteins (FABP4, IL-6, TIM-1 and AM) that could be of importance in the development of AF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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