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Artificial selectio...
Artificial selection response due to polygenic adaptation from a multilocus, multiallelic genetic architecture
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- Zan, Yanjun (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Carlborg,Uppsala University
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- Sheng, Zheya (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Huazhong Agricultural University
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- Lillie, Mette (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Carlborg,Uppsala University
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- Rönnegård, Lars (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Högskolan Dalarna,Statistik,SLU,Carlborg,Institutionen för kliniska vetenskaper (KV),Institutionen för husdjursgenetik (HGEN),Department of Clinical Sciences,Department of Animal Breeding and Genetics,Dalarna University
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Honaker, Christa F (författare)
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Siegel, Paul B (författare)
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- Carlborg, Örjan (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,SLU,Uppsala University
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(creator_code:org_t)
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- 2017-07-11
- 2017
- Engelska.
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Ingår i: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 34:10, s. 2678-2689
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- The ability of a population to adapt to changes in their living conditions, whether in nature or captivity, often depends on polymorphisms in multiple genes across the genome. In-depth studies of such polygenic adaptations are difficult in natural populations, but can be approached using the resources provided by artificial selection experiments. Here, we dissect the genetic mechanisms involved in long-term selection responses of the Virginia chicken lines, populations that after 40 generations of divergent selection for 56-day body weight display a 9-fold difference in the selected trait. In the F15 generation of an intercross between the divergent lines, 20 loci explained >60% of the additive genetic variance for the selected trait. We focused particularly on fine-mapping seven major QTL that replicated in this population and found that only two fine-mapped to single, bi-allelic loci; the other five contained linked loci, multiple alleles or were epistatic. This detailed dissection of the polygenic adaptations in the Virginia lines provides a deeper understanding of the range of different genome-wide mechanisms that have been involved in these long-term selection responses. The results illustrate that the genetic architecture of a highly polygenic trait can involve a broad range of genetic mechanisms, and that this can be the case even in a small population bred from founders with limited genetic diversity.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Nyckelord
- epistasis
- genetic architecture
- genetic variation
- multiallelic
- multilocus
- polygenic adaptation
- Complex Systems – Microdata Analysis
- Komplexa system - mikrodataanalys
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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