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Systemic inflammato...
Systemic inflammatory markers in relation to lung function in NHANES. 2007–2010
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- Nerpin, Elisabet, 1962- (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala University,Lung- allergi- och sömnforskning,Klinisk fysiologi,Dalarna Univ, Dept Med Hlth & Social Studies, Falun, Sweden
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- Jacinto, Tiago (författare)
- Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res, Porto, Portugal
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- Fonseca, João A. (författare)
- Univ Porto, Fac Med, Dept Biostat & Med Informat, Porto, Portugal
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- Alving, Kjell, 1959- (författare)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Klinisk fysiologi
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 142, s. 94-100
- Relaterad länk:
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http://www.resmedjou...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background Low-grade systemic inflammation, mainly assessed by C-reactive protein (CRP), has been associated with impaired lung function. Few studies have studied if CRP, blood eosinophils, and blood neutrophils offer additive information in relation to lung function. Objectives To analyse associations between lung function and CRP, blood eosinophils, and blood neutrophils, with special regard to additive information of combining the inflammatory markers. Methods Cross-sectional study on 7753 participants, 20–80 years of age, in the National Health and Nutrition Examination Survey. Gender-based tertiles for CRP, blood eosinophils, and blood neutrophils were analysed in relation to the following lung function parameters: forced expiratory volume in 1 s (FEV1% predicted), forced vital capacity (FVC % predicted), and FEV1/FVC ratio. Results CRP, blood eosinophils, and blood neutrophils levels were inversely related to FEV1 and FVC. Only blood eosinophils and blood neutrophils were inversely related to FEV1/FVC ratio. Further, lower lung function was found with increased number of elevated inflammatory markers in the highest tertile (one, two or three vs. non elevated) for FEV1 (β-coeff., −2.20, −4.43, and −6.43, p < 0.001) and FVC (β-coeff., −1.70, −3.15 and −5.33, p < 0.001), respectively. Conclusions & clinical relevance CRP, blood eosinophils, and blood neutrophils offer independent and additive information in relation to lower FEV1 and FVC in the general population. This indicates that a combination of biomarkers yields more information than the biomarkers assessed individually.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Inflammation
- CRP
- Blood eosinophils
- Blood neutrophils
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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