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Albuminuria as a pr...
Albuminuria as a predictor of cardiovascular outcomes in patients with acute myocardial infarction
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Mok, Yejin (författare)
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Ballew, Shoshana H (författare)
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Sang, Yingying (författare)
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- Grams, Morgan E (författare)
- Karolinska Institutet
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Coresh, Josef (författare)
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Evans, Marie (författare)
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- Barany, Peter (författare)
- Karolinska Institutet
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- Ärnlöv, Johan, 1970- (författare)
- Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet
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- Carrero, Juan-Jesus (författare)
- Karolinska Institutet
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Matsushita, Kunihiro (författare)
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(creator_code:org_t)
- 2019
- 2019
- Engelska.
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 8:8
- Relaterad länk:
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https://doi.org/10.1...
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https://du.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background. In patients with myocardial infarction ( MI ), reduced kidney function is recognized as an important predictor of poor prognosis, but the impact of albuminuria, a representative measure of kidney damage, has not been extensively evaluated.Methods and Results. In the SCREAM (Stockholm Creatinine Measurements) project (2006-2012), we identified 2469 patients with incident MI with dipstick proteinuria measured within a year before MI (427 patients also had urine albumin to creatinine ratio [ ACR ] measured concurrently) and obtained estimates for ACR with multiple imputation in participants with data solely on dipstick proteinuria. We quantified the association of ACR with the post- MI composite and individual outcomes of all-cause mortality, cardiovascular mortality, recurrent MI , ischemic stroke, or heart failure using Cox models and then evaluated the improvement in C statistic. During a median follow-up of 1.0 year after MI , 1607 participants (65.1%) developed the post- MI composite outcome. Higher ACR levels were independently associated with all outcomes except for ischemic stroke. Per 8-fold higher ACR (eg, 40 versus 5 mg/g), the hazard ratio of composite outcome was 1.21 (95% CI , 1.08-1.35). The addition of the ACR improved the C statistic of the post- MI composite by 0.040 (95% CI, 0.030-0.051). Largely similar results were obtained regardless of diabetic status and when ACR or dipstick was separately analyzed without imputation.Conclusions. In patients with MI , albuminuria was a potent predictor of subsequent outcomes, suggesting the importance of paying attention to the information on albuminuria, in addition to kidney function, in this high-risk population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- albuminuria
- chronic kidney disease
- myocardial infarction
- prognosis
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Mok, Yejin
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Ballew, Shoshana ...
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Sang, Yingying
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Grams, Morgan E
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Coresh, Josef
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Evans, Marie
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visa fler...
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Barany, Peter
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Ärnlöv, Johan, 1 ...
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Carrero, Juan-Je ...
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Matsushita, Kuni ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Journal of the A ...
- Av lärosätet
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Högskolan Dalarna
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Karolinska Institutet