Sökning: id:"swepub:oai:DiVA.org:du-30083" >
Dual-task performan...
Dual-task performance and neurodegeneration : Correlations between timed up-and-go dual-task test outcomes and Alzheimer's disease cerebrospinal fluid biomarkers
-
- Åhman, Hanna Bozkurt (författare)
- Uppsala universitet,Geriatrik
-
- Giedraitis, Vilmantas (författare)
- Uppsala universitet,Geriatrik
-
- Cedervall, Ylva (författare)
- Uppsala universitet,Geriatrik
-
visa fler...
-
- Lennhed, Björn (författare)
- Falu Lasarett, Dept Geriatr & Rehabil Med, Falun, Sweden
-
- Berglund, Lars, Docent, 1955- (författare)
- Uppsala universitet,Geriatrik
-
- McKee, Kevin, 1961- (författare)
- Högskolan Dalarna,Socialt arbete,Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden
-
- Kilander, Lena (författare)
- Uppsala universitet,Geriatrik,Uppsala Univ, Dept Publ Hlth & Caring Sci, Box 564, SE-75122 Uppsala, Sweden
-
- Rosendahl, Erik (författare)
- Umeå universitet,Avdelningen för fysioterapi,Umea Univ, Dept Community Med & Rehabil, Umea, Sweden
-
- Ingelsson, Martin (författare)
- Uppsala universitet,Geriatrik,Uppsala Univ, Dept Publ Hlth & Caring Sci, Box 564, SE-75122 Uppsala, Sweden
-
- Åberg, Anna Cristina (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala University,Geriatrik,Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden
-
visa färre...
-
(creator_code:org_t)
- IOS Press, 2019
- 2019
- Engelska.
-
Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 71:Suppl 1, s. S75-S83
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://du.diva-port... (primary) (Raw object)
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Tools to identify individuals at preclinical stages of dementia disorders are needed to enable early interventions. Alterations in dual-task performance have been detected early in progressive neurodegenerative disorders. Hence, dual-task testing may have the potential to screen for cognitive impairment caused by neurodegeneration. Exploring correlations between dual-task performance and biomarkers of neurodegeneration is therefore of interest.OBJECTIVE: To investigate correlations between Timed Up-and-Go dual-task (TUGdt) outcomes and Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers amyloid-β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau).METHODS: This cross-sectional cohort study included 90 participants (age range 49-84 years) undergoing memory assessment, who were subsequently diagnosed with AD, other dementia disorders, mild cognitive impairment, or subjective cognitive impairment. TUG combined with "Naming Animals" (TUGdt NA) and "Months Backwards" (TUGdt MB), respectively, were used to assess dual-task performance. The number of correct words and time taken to complete the tests were measured. The CSF biomarkers were analysed by ELISA. Spearman's rank correlation was used for analyses between TUGdt outcomes (TUGdt NA and TUGdt MB), and CSF biomarkers, adjusted for age, gender, and educational level.RESULTS: The number of correct words, as well as the number of correct words/10 s during TUGdt NA correlated negatively to CSF t-tau and p-tau. No correlations were found between any time scores and CSF biomarkers.CONCLUSION: The correlations between TUGdt NA and t-tau and p-tau may indicate that neurodegeneration affects dual-task performance. Longitudinal studies are needed to further explore dual-task testing in screening for cognitive impairment due to neurodegeneration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer’s disease
- attention
- biomarkers
- cerebrospinal fluid
- dementia
- executive function
- gait
- mild cognitive impairment
- subjective cognitive impairment
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Åhman, Hanna Boz ...
-
Giedraitis, Vilm ...
-
Cedervall, Ylva
-
Lennhed, Björn
-
Berglund, Lars, ...
-
McKee, Kevin, 19 ...
-
visa fler...
-
Kilander, Lena
-
Rosendahl, Erik
-
Ingelsson, Marti ...
-
Åberg, Anna Cris ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Geriatrik
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Journal of Alzhe ...
- Av lärosätet
-
Högskolan Dalarna
-
Umeå universitet
-
Uppsala universitet