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Differences in nitr...
Differences in nitric oxide airway diffusion after maximum oxygen uptake test in asthmatic and nonasthmatic elite junior cross-country skiers
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- Högman, Marieann (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Wedholm, Lars (författare)
- Högskolan Dalarna,Idrotts- och hälsovetenskap,Falun Hospital, Falun, Region Dalarna,Falun Cent Hosp, Dept Med, Falun, Sweden.;Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden.
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- Carlsson, Tomas (författare)
- Högskolan Dalarna,Idrotts- och hälsovetenskap,Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden.
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- Carlsson, Magnus (författare)
- Högskolan Dalarna,Idrotts- och hälsovetenskap,Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden.
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- Tonkonogi, Michail, 1967- (författare)
- Högskolan Dalarna,Medicinsk vetenskap,Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden.
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(creator_code:org_t)
- 2020-11-19
- 2021
- Engelska.
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Ingår i: ERJ Open Research. - : European Respiratory Society (ERS). - 2312-0541. ; 7:1
- Relaterad länk:
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https://doi.org/10.1...
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https://du.diva-port... (primary) (Raw object)
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https://openres.ersj...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Asthma is common in cross-country skiers and is often treated with ß2-agonists and inhaled corticosteroids (ICS). Exhaled nitric oxide is often used to guide ICS treatment in asthma. This study investigated the change in the pulmonary NO dynamics before and after a maximum oxygen uptake (V̇O2-max) test.An extended NO analysis was performed among Swedish elite junior cross-country skiers (n=25), with and without declared asthma, before and after a V̇O2-max test using roller skis. Asthma was declared by six boys and two girls among whom five occasionally used ICS.There were no differences in the baseline NO parameters between those with and without declared asthma. The diffusion capacity over airway wall (DawNO) was 21 (17,25) mL·s−1 (median, quartiles), which is much increased for this age group. After the V̇O2-max test, there were statistically significant differences from the baseline fraction of exhaled nitric oxide (FENO50), NO-flux from airways, DawNO and alveolar NO values; but not in the NO content in airway wall (CawNO) for all subjects together as one group. However, in the asthma group, differences were only seen in the FENO50 and in CawNO.Interestingly, a majority of the subjects had an increase in the DawNO. An increase in DawNO has been found with allergic asthma together with elevated CawNO. The skiers did not have elevated CawNO, which indicates an absence of inflammation in the airway wall. Modelling of lung NO production clearly shows that the asthma among our skiers is distinct from the allergic asthma in non-athletes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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