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Fatigue in Cancer P...
Fatigue in Cancer Patients in Palliative Care : A Review on Pharmacological Interventions.
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- Klasson, Caritha (författare)
- Karolinska Institutet,Karolinska institutet; Stiftelsen Stockholms sjukhem,Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet; Palliative Medicine, Stockholms Sjukhem Foundation
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- Helde Frankling, Maria (författare)
- Karolinska Institutet,Karolinska institutet; Stiftelsen Stockholms sjukhem,Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet; Palliative Medicine, Stockholms Sjukhem Foundation
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- Lundh Hagelin, Carina (författare)
- Marie Cederschiöld högskola,Karolinska Institutet,Ersta Sköndal Bräcke högskola,Institutionen för vårdvetenskap,Department of Neurobiology, Care Sciences and Society (NVS), Division of Nursing, Karolinska Institutet,Palliativt forskningscentrum, PFC
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- Björkhem-Bergman, Linda (författare)
- Karolinska Institutet,Karolinska institutet; Stiftelsen Stockholms sjukhem,Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet; Palliative Medicine, Stockholms Sjukhem Foundation
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(creator_code:org_t)
- 2021-02-26
- 2021
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 13:5
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Fatigue is one of the most distressing symptoms experienced by cancer patients. The suggested biological mechanism for cancer related fatigue (CRF) includes immune activation triggered by tumor tissue or by anticancer treatment but other mechanisms have also been proposed. Previous large meta-analysis of interventions on fatigue focuses mostly on patients early in the disease trajectory, with only one tenth of included studies performed in palliative cohorts. The aim of this narrative review is therefore to present a background on CRF with focus on the palliative setting. A summary of recent randomized, controlled trials on pharmacological interventions on CRF in palliative care is presented, including studies on psychostimulants, corticosteroids, testosterone and melatonin. Interestingly, in several of these studies there was a positive and similar effect on fatigue in both the intervention and the placebo arm-indicating an important placebo effect for any pharmacological treatment. In addition, studies on dietary supplements and on pharmacological complementary medicines are discussed. To conclude, the evidence is still weak for using pharmacological treatments on CRF in palliative care patients-although methylphenidate and corticosteroids might be considered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Cancer
- Cancer related fatigue
- Clinical trials
- Fatigue
- Palliative care
- Therapeutics
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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