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Impact of sex and A...
Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults : A longitudinal study.
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- Wang, Rui (author)
- Karolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Karolinska Institutet and Stockholm University, Stockholm, Sweden,Fysisk aktivitet och hjärnhälsa
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- Oh, Jennifer M (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Middleton Memorial Veterans Hospital, Madison, WI, USA.
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- Motovylyak, Alice (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Ma, Yue (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Sager, Mark A (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Rowley, Howard A (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Johnson, Kevin M (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Gallagher, Catherine L (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Carlsson, Cynthia M (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Bendlin, Barbara B (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Johnson, Sterling C (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Asthana, Sanjay (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Eisenmenger, Laura (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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- Okonkwo, Ozioma C (author)
- University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
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(creator_code:org_t)
- Sage Publications, 2021
- 2021
- English.
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In: Journal of Cerebral Blood Flow and Metabolism. - : Sage Publications. - 0271-678X .- 1559-7016. ; 41:11, s. 3016-3027
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https://doi.org/10.1...
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https://gih.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40-89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with APOE-genotype, biological sex, and cardiometabolic measurements. During the follow-up period (range 0.13-8.24 years), increasing age was significantly associated with decreasing cerebral perfusion, in total gray-matter (β=-1.43), hippocampus (-1.25), superior frontal gyrus (-1.70), middle frontal gyrus (-1.99), posterior cingulate (-2.46), and precuneus (-2.14), with all P-values < 0.01. Compared with male-ɛ4 carriers, female-ɛ4 carriers showed a faster decline in global and regional cerebral perfusion with increasing age, whereas the age-related decline in cerebral perfusion was similar between male- and female-ɛ4 non-carriers. Worse cardiometabolic profile (i.e., increased blood pressure, body mass index, total cholesterol, and blood glucose) was associated with lower cerebral perfusion at all the visits. When time-varying cardiometabolic measurements were adjusted in the model, the synergistic effect of sex and APOE-ɛ4 on age-related cerebral perfusion-trajectories became largely attenuated. Our findings demonstrate that APOE-genotype and sex interactively impact cerebral perfusion-trajectories in mid- to late-life. This effect may be partially explained by cardiometabolic alterations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- APOE gene
- Alzheimer’s disease
- Cerebral perfusion
- cardiometabolic measurements
- chromosomal sex
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wang, Rui
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Oh, Jennifer M
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Motovylyak, Alic ...
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Ma, Yue
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Sager, Mark A
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Rowley, Howard A
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show more...
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Johnson, Kevin M
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Gallagher, Cathe ...
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Carlsson, Cynthi ...
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Bendlin, Barbara ...
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Johnson, Sterlin ...
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Asthana, Sanjay
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Eisenmenger, Lau ...
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Okonkwo, Ozioma ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Cereb ...
- By the university
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The Swedish School of Sport and Health Sciences
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Karolinska Institutet