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Effects of Tryptoph...
Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans.
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- Valente-Silva, Paula (author)
- Karolinska Institutet, Stockholm, Sweden
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- Cervenka, Igor (author)
- Karolinska Institutet, Stockholm, Sweden
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- Ferreira, Duarte M S (author)
- Karolinska Institutet
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- Correia, Jorge C (author)
- Karolinska Institutet
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- Edman, Sebastian (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Horwath, Oscar, 1991- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Heng, Benjamin (author)
- Macquarie University, Sidney, Australia
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- Chow, Sharron (author)
- Macquarie University, Sidney, Australia
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- Jacobs, Kelly R (author)
- Macquarie University, Sidney, Australia
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- Guillemin, Gilles J (author)
- Macquarie University, Sidney, Australia
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- Blomstrand, Eva (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Ruas, Jorge L (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-08-03
- 2021
- English.
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In: Metabolites. - : MDPI AG. - 2218-1989 .- 2218-1989. ; 11:8
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Abstract
Subject headings
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- The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors energy expenditure and an anti-inflammatory immune cell profile and reduces neurotoxic metabolites. Here, we aimed to understand if TRP supplementation in untrained vs. trained subjects affects KP metabolite levels and biological effects. Our data show that chronic TRP supplementation in mice increases all KP metabolites in circulation, and that exercise reduces the neurotoxic branch of the pathway. However, in addition to increasing wheel running, we did not observe other effects of TRP supplementation on training adaptations, energy metabolism or behavior in mice. A similar increase in KP metabolites was seen in trained vs. untrained human volunteers that took a TRP drink while performing a bout of aerobic exercise. With this acute TRP administration, TRP and KYN were higher in the trained vs. the untrained group. Considering the many biological effects of the KP, which can lead to beneficial or deleterious effects to health, our data encourage future studies of the crosstalk between TRP supplementation and physical exercise.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- behavior
- dietary supplements
- energy metabolism
- exercise
- kynurenine metabolites
- skeletal muscle
- tryptophan
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Valente-Silva, P ...
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Cervenka, Igor
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Ferreira, Duarte ...
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Correia, Jorge C
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Edman, Sebastian
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Horwath, Oscar, ...
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show more...
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Heng, Benjamin
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Chow, Sharron
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Jacobs, Kelly R
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Guillemin, Gille ...
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Blomstrand, Eva
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Ruas, Jorge L
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
- Articles in the publication
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Metabolites
- By the university
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The Swedish School of Sport and Health Sciences
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Karolinska Institutet