Sökning: id:"swepub:oai:DiVA.org:gih-960" >
Repeated resistance...
Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle.
-
- Mascher, Henrik (författare)
- Karolinska Institutet,Gymnastik- och idrottshögskolan,Eva Blomstrands forskningsgrupp
-
- Tannerstedt, Jörgen (författare)
- Gymnastik- och idrottshögskolan,Eva Blomstrands forskningsgrupp
-
- Brink-Elfegoun, Thibault (författare)
- Gymnastik- och idrottshögskolan,Institutionen för idrotts- och hälsovetenskap
-
visa fler...
-
- Ekblom, Björn (författare)
- Gymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp
-
- Gustafsson, Thomas (författare)
- Karolinska Institutet
-
- Blomstrand, Eva (författare)
- Gymnastik- och idrottshögskolan,Eva Blomstrands forskningsgrupp
-
visa färre...
-
(creator_code:org_t)
- American Physiological Society, 2008
- 2008
- Engelska.
-
Ingår i: American Journal of Physiology. Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 294:1, s. E43-51
- Relaterad länk:
-
http://ajpendo.physi...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The gain in muscle mass as a result of resistance training is dependent on changes in both anabolic and catabolic reactions. A frequency of two to three exercise sessions per week is considered optimal for muscle gain in untrained individuals. Our hypothesis was that a second exercise session would enlarge the anabolic response and/or decrease the catabolic response. Eight male subjects performed resistance exercise on two occasions separated by 2 days. Muscle biopsies were taken from the vastus lateralis before and 15 min, 1 h, and 2 h after exercise. Exercise led to severalfold increases in phosphorylation of mTOR at Ser2448, p70 S6 kinase (p70S6k) at Ser424/Thr421 and Thr389, and ribosomal protein S6, which persisted for up to 2 h of recovery on both occasions. There was a tendency toward a larger effect of the second exercise on p70S6k and S6, but the difference did not reach statistical significance. The mRNA expression of MuRF-1, which increased after exercise, was 30% lower after the second exercise session than after the first one. MAFbx expression was not altered after exercise but downregulated 30% 48 h later, whereas myostatin expression was reduced by 45% after the first exercise and remained low until after the second exercise session. The results indicate that 1) changes in expression of genes involved in protein degradation are attenuated as a response to repetitive resistance training with minor additional increases in enzymes regulating protein synthesis and 2) the two ubiquitin ligases, MuRF-1 and MAFbx, are differently affected by the exercise as well as by repeated exercise.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas