Myocardial Protective Effect of Maintained Beta-Blockade in Aorto-Coronary Bypass Surgery

• Twenty-nine patients were randomly allocated to two groups before undergoing aorto-coronary bypass surgery. In one group the beta-blocking medication was withdrawn three days preoperatively, and in the other group it was maintained. The patients in the latter group were additionally given 100 mg metoprolol per os two hours before surgery. The degree of myocardial injury, as judged from cumulated activity of S-CK B, was less when the beta-blockade was maintained.

Nyckelord

pharmacology

adrenergic beta-antagonists

clinical trials as topic

coronary artery bypass

coronary disease

creatine kinase

heart

induced heart arrest

preoperative care

random allocation

drug effects

surgery

blood

therapeutic use

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)