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B-cells and Inflamm...
B-cells and Inflammation in the Absence of the Abelson Related Gene (Arg)
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- Andersson, Åsa, 1960- (författare)
- Högskolan i Halmstad,Rydberglaboratoriet för tillämpad naturvetenskap (RLAS),University of Copenhagen, Copenhagen, Denmark
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- Aksel Jacobsen, Freja (författare)
- Copenhagen University, Copenhagen, Denmark
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Journal of Clinical & Cellular Immunology. - Los Angeles, CA : Omics Publishing Group. - 2155-9899. ; 7:6
- Relaterad länk:
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https://doi.org/10.4...
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https://hh.diva-port... (primary) (Raw object)
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https://www.omicsonl...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- The Abelson non-receptor tyrosine kinases, c-Abl and Arg, are important regulators of cellular processes in cancer, inflammation, infection, and neuronal dynamics. Recent research on the role for these kinases in processes involving interactions with the cytoskeleton or signaling molecules, may lead to further insight into the pathogenesis of a variety of disorders, including chronic inflammatory diseases. In a mouse model for multiple sclerosis, we recently reported that Arg deficient mice develop T-cell mediated autoimmune neuro-inflammation with the same severity as littermate controls, but display a different B-cell phenotype upon immunization. Here we comment on these results and discuss the role for Arg in B-cell activation and homeostasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Arg/Abl2
- c-Abl
- Experimental autoimmune encephalomyelitis (EAE)
- B-cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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