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SNX10 (sorting nexi...
SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC
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- Zhang, Sulin (författare)
- School of Pharmacy, Fudan University, Shanghai, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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- Yang, Zhiwen (författare)
- Shanghai Jiao Tong University, Shanghai, China
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- Bao, Weilian (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Liu, Lixin (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- You, Yan (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Wang, Xu (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Shao, Liming (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Fu, Wei (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Kou, Xinhui (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Shen, Weixing (författare)
- Nanjing University of Traditional Chinese Medicine, Nanjing, China
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- Yuan, Congmin (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Hu, Bin (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Dang, Wenzhen (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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- Nandakumar, Kutty Selva, 1965- (författare)
- Southern Medical University, Guangzhou, China
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- Jiang, Hualiang (författare)
- Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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- Zheng, Mingyue (författare)
- Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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- Shen, Xiaoyan (författare)
- School of Pharmacy, Fudan University, Shanghai, China
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(creator_code:org_t)
- 2019-07-04
- 2020
- Engelska.
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Ingår i: Autophagy. - Philadelphia : Taylor & Francis. - 1554-8627 .- 1554-8635. ; 16:4, s. 735-749
- Relaterad länk:
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https://doi.org/10.1...
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The non-receptor tyrosine kinase SRC is a key mediator of cellular protumorigenic signals. SRC is aberrantly over-expressed and activated in more than 80% of colorectal cancer (CRC) patients, therefore regulation of its stability and activity is essential. Here, we report a significant down regulation of SNX10 (sorting nexin 10) in human CRC tissues, which is closely related to tumor differentiation, TNM stage, lymph node metastasis and survival period. SNX10 deficiency in normal and neoplastic colorectal epithelial cells promotes initiation and progression of CRC in mice. SNX10 controls SRC levels by mediating autophagosome-lysosome fusion and SRC recruitment for autophagic degradation. These mechanisms ensure proper controlling of the activities of SRC-STAT3 and SRC-CTNNB1 signaling pathways by up-regulating SNX10 expression under stress conditions. These findings suggest that SNX10 acts as a tumor suppressor in CRC and it could be a potential therapeutic target for future development.Abbreviations: ACTB: actin beta; ATG5: autophagy related 5; ATG12: autophagy related 12; CQ: chloroquine; CRC: colorectal cancer; CTNNB1: catenin beta 1; EBSS: Earle's balanced salt solution; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LAMP2: lysosomal associated membrane protein 2; MAP1LC3: microtubule associated protein 1 light chain 3; MKI67: marker of proliferation Ki-67; mRNA: messenger RNA; PX: phox homology; RT-qPCR: real time quantitative polymerase chain reaction; siRNA: small interfering RNA; SNX10: sorting nexin 10; SQSTM1: sequestosome 1; SRC: SRC proto-oncogene, non-receptor tyrosine kinase; STAT3: signal transducer and activator of transcription 3; WT: wild type. © 2019 Informa UK Limited, trading as Taylor & Francis Group
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Colorectal cancer
- SNX10
- SRC
- macroautophagy
- tumor growth
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Zhang, Sulin
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Yang, Zhiwen
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Bao, Weilian
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Liu, Lixin
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You, Yan
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Wang, Xu
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visa fler...
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Shao, Liming
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Fu, Wei
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Kou, Xinhui
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Shen, Weixing
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Yuan, Congmin
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Hu, Bin
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Dang, Wenzhen
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Nandakumar, Kutt ...
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Jiang, Hualiang
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Zheng, Mingyue
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Shen, Xiaoyan
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Autophagy
- Av lärosätet
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Högskolan i Halmstad