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An update on smart ...
An update on smart biocatalysts for industrial and biomedical applications
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- Shakya, Akhilesh Kumar (författare)
- Chemical Engineering Department, Texas Tech University, Lubbock, TX, USA
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- Nandakumar, Kutty Selva, 1965- (författare)
- Karolinska Institutet,School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China; Department of Medical Biophysics and Biochemistry, Karolinska Institute, Stockholm, Sweden
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(creator_code:org_t)
- 2018-02-28
- 2018
- Engelska.
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Ingår i: Journal of the Royal Society Interface. - : The Royal Society. - 1742-5689 .- 1742-5662. ; 15:139
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Abstract
Ämnesord
Stäng
- Recently, smart biocatalysts, where enzymes are conjugated to stimuli-responsive (smart) polymers, have gained significant attention. Based on the presence or absence of external stimuli, the polymer attached to the enzyme changes its conformation to protect the enzyme from the external environment and regulate the enzyme activity, thus acting as a molecular switch. Owing to this behaviour, smart biocatalysts can be separated easily from a reaction mixture and re-used several times. Several such smart polymer-based biocatalysts have been developed for industrial and biomedical applications. In addition, they have been used in biosensors, biometrics and nano-electronic devices. This review article covers recent advances in developing different kinds of stimuli-responsive enzyme bioconjugates, including conjugation strategies, and their applications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Nyckelord
- industrial biocatalyst
- magnetic smart biocatalyst
- responsive polymer
- smart biocatalyst
- therapeutic biocatalyst
- thermo-responsive biocatalyst
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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