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Immunohistochemical...
Immunohistochemical localization of alpha(1a)-adrenoreceptors in muscle spindles of rabbit masseter muscle
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- Bombardi, C. (författare)
- Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy
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- Grandis, A. (författare)
- Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy
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- Chiocchetti, R. (författare)
- Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy
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- Bortolami, R. (författare)
- Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy
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- Johansson, Håkan (författare)
- Högskolan i Gävle,Centrum för belastningsskadeforskning
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- Lucchi, M. L. (författare)
- Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
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Ingår i: Tissue & Cell. - : Elsevier BV. - 0040-8166 .- 1532-3072. ; 38:2, s. 121-125
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The expression of alpha(1a)-adrenoreceptors (alpha(1a)-ARs) within the muscle spindles of rabbit masseter muscle was investigated. The alpha(1a)-ARs were detected by immunohistochemical fluorescent method and examined along the entire length of 109 cross serially sectioned spindles. The sympathetic fibers were visualized by the immunofluorescent labeling of the noradrenaline synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). In order to recognize the intrafusal muscle fiber types, antibodies for different myosin heavy chain isoforms (MyHCI) were used. TH and DBH immunolabeled nerve fibers have been observed within the capsule lamellar layers, in the periaxial fluid space and close to intrafusal muscle fibers. The alpha(1a)-ARs were detected on the smooth muscle cells of the blood vessels coursing in the muscle and in the capsule lamellar layers or within the periaxial fluid space of the spindles. Moreover, at the polar regions of a high percentage (88.1%) of muscle spindles a strong alpha(1a)-ARs immunoreactivity was present on the intrafusal muscle fibers. In double immunostained sections for alpha(1a)-ARs and MyHCI it was evidenced that both bag, and nuclear chain fibers express alpha(1a)-ARs. The receptors that we have detected by immunofluorescence may support a direct control by adrenergic fibers on muscle spindle.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Animals
- Immunohistochemistry methods
- Male
- Masseter
- Muscle cytology metabolism ultrastructure
- Muscle Fibers cytology metabolism
- Muscle Spindles cytology metabolism ultrastructure
- Neurotransmitter
- Agents metabolism
- Norepinephrine metabolism
- Rabbits
- Receptors
- Adrenergic alpha-1 immunology metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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